A5102844427- Helicobacter pylori-related gastroenterology studies
- Regulation of Appetite and Obesity
- Thyroid Disorders and Treatments
- Biochemical Analysis and Sensing Techniques
- Gastroesophageal reflux and treatments
- Adipose Tissue and Metabolism
- Celiac Disease Research and Management
- Growth Hormone and Insulin-like Growth Factors
- Gastrointestinal motility and disorders
- Pancreatic function and diabetes
- Veterinary medicine and infectious diseases
- Genetic Syndromes and Imprinting
- Gastrointestinal disorders and treatments
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Microscopic Colitis
- Thyroid Cancer Diagnosis and Treatment
- Digestive system and related health
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Microbial Metabolites in Food Biotechnology
- Immunodeficiency and Autoimmune Disorders
- Galectins and Cancer Biology
- Eosinophilic Esophagitis
- Neonatal Health and Biochemistry
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2005-2017
Sapienza University of Rome
2000
University of Turin
1998
University of Milan
1998
Ospedale Maggiore
1998
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
1998
Eurospital (Italy)
1997
Objective: The aim of the study was to examine clinical characteristics, biochemical parameters, and TSH-R gene variations in children adolescents with subclinical hypothyroidism (SH) order evaluate their pattern distribution SH. Patients: We enrolled 88 patients, each having at least two TSH measurements above upper limit reference range normal free thyroid hormones negative autoantibodies. Main Outcome Measures: Clinical characteristics included height, weight, family history diseases,...
The clinical presentation of celiac disease in children changed the last decades 20th century. To ascertain whether changes are still progress, we analyzed symptoms at and age diagnosis 307 receiving diagnoses for past 20 years. prevalence typical forms decreased decade, particularly 5 years (from 76% 1987-1990 to 44%, P < 0.0001). Age (5.9 y, = 0.01) silent (10.6%, 0.003) have significantly increased Histological examination showed subtotal partial villous atrophy (P 0.02).
Previous investigations on the ghrelin gene reported three common polymorphisms (Arg51Gln, Leu72Met, and Gln90Leu), but their role in overweight obese individuals remains to be clarified.To ascertain whether these genetic variants could influence secretion play a part predisposing earlier onset of obesity or modulating phenotype childhood.Mutational analysis entire total acylated plasma determinations were performed 81 children adolescents (46 35 overweight: Ob/Ow). We also recruited 168...
<h3>AIMS</h3> To define the aetiology of neonatal transient hypothyroidism (NTH) and recommend preventive measures. <h3>METHODS</h3> Maternal perinatal clinical data on use antiseptics, drugs, contrast agents containing iodine were collected from 40 subjects. Thyroid stimulating hormone (TSH), free thyroxine (FT4), (T4), thyroglobulin (TG), TSH receptor antibodies, thyroid peroxidase antibodies urinary measured in random samples. In mothers with known or suspected disorders, TSH, FT4, also...
Summary objective Circulating ghrelin levels are increased by fasting and decreased feeding, glucose load, insulin somatostatin. Whether hyperglycaemia directly inhibit secretion still remains matter of debate. The aim the present study was therefore to investigate further regulatory effects on secretion. design subjects We studied [oral tolerance test (OGTT) 100 g orally], insulin‐induced hypoglycaemia [ITT, 0·1 IU/kg intravenously (i.v.)], glucagon (1 mg i.v.), arginine (0·5 mg/kg i.v.)...
The aim of this study was to evaluate performance serum antibodies against deamidated gliadin peptides (a-DGPs) in detecting compliance with gluten-free diet (GFD) children celiac disease (CD).Serum samples were collected the same day endoscopy 95 CD and 106 controls. We preliminarily calculated cutoff a-DGP immunoglobulin A (IgA) IgA+G our population by receiver operating characteristic (ROC) curves. Of CD, 28 studied during first year after GFD introduction, interview collection every 3...
Summary Objective TSH resistance ranges from overt nonautoimmune hypothyroidism to subclinical hypothyroidism, defined as mild hyperthyrotrophinaemia but a euthyroid state clinically. To date, 23 inactivating mutations of the receptor (TSHR) gene have been proven responsible for clinical condition, an absence in TSHR has reported several cases well. In this paper, we aimed investigate actual role development both and congenital hypothyroidism. Patients 14 hypothyroid newborns, 116 subjects...
The presence of both the GH secretagogue (GHS) receptor and ghrelin in pancreas indicates an involvement this hormone glucose metabolism. Ghrelin secretion is increased by fasting energy restriction, decreased food intake, load, insulin somatostatin normal adults; however, intake not able to inhibit circulating levels children, suggesting that profile children different from adults. Moreover, how regulated childhood as a function fat mass still unclear.We studied effect oral load (75 g...
Summary objective Ghrelin exerts potent GH‐releasing activity and stimulates food intake. Circulating ghrelin levels are increased in anorexia cachexia, reduced obesity restored by weight recovery. Newborns characterized GH hypersecretion associated with low IGF‐I reflecting peripheral resistance. study design The aim of our was to measure cord 117 newborns appropriate for gestational age, born either at term or preterm. results blood (median; 25th−75th centile: 327·6; 206·0–413·0 pg/ml)...
Abstract Ghrelin, a natural GH secretagogue, is predominantly produced by the stomach. Ghrelin has other actions including orexant activity, modulation of energy balance, and endocrine nonendocrine functions. secretion increased fasting restriction but decreased food intake, glucose, insulin, somatostatin. does not seem to be function age; in fact, morning ghrelin levels after overnight prepubertal pubertal children are similar those young adults. To clarify whether adults have same...
The monitoring of the results eradication treatment is a crucial step for patients with Helicobacter pylori gastritis. A non-invasive test H. antigens in stools (HpSA) was recently validated children.To evaluate accuracy HpSA children.In 60 children, gastritis diagnosed by endoscopy and 13C-urea breath test. children were treated returned follow-up (13)C-urea 6 weeks after end treatment. Children considered cured when negative. Stool collected at baseline, 2 weeks. measured HpSA.According to...
We aimed to identify potential correlates or risk factors for metabolic syndrome (MetS) in a cohort of schoolchildren. quantified the prevalence MetS, analysed clustering MetS components and described distribution parameters not included definition.Population-based, cross-sectional study.A total 489 children (6·7-13 years) representing 92·6% whole school population between 1st year primary 2nd junior high living centre southern Italy. Weight, height, waist circumference, blood pressure (BP),...
A relationship between ghrelin and epilepsy has been already shown in humans, although the results are controversial. Ghrelin levels reduced obesity. Epileptic patients progressively develop a therapy-linked weight gain; however, mechanisms for this have not fully explained. The aim of our study is to evaluate if secretion modulated by treatment with carbamazepine or valproic acid young prepubertal epileptic children. were normal-weight children under (p < 0.0001) 0.006) compared healthy...
ABSTRACT Background: A protective effect of Helicobacter pylori infection against allergic diseases has been reported. The increasing incidence childhood allergy in developed countries may be a result reduced stimulation the immune system by early chronic infections, with gastrointestinal microbes being mediated regulatory T lymphocytes and production interleukin (IL)‐10. To elucidate possible mechanism involved protecting development atopy, we measured expression IL‐10 gastric mucosa...
Abstract Aim: To assess validity of culture on four‐sector agar plates and fluorescent in‐situ hybridization (FISH) test, clarithromycin resistance rate in Helicobacter pylori strains isolated from children the last 10 years. Methods: In 5 years, gastric biopsy specimens antrum fundus were taken 89 consecutive (median age 9 years) with H. gastritis 21 controls. Culture was performed 176 biopsies (89 antrum, 87 fundus) plates, FISH test DNA ProbeMix ® . After its evaluated, applied additional...