A5062663419- Growth Hormone and Insulin-like Growth Factors
- Neonatal Respiratory Health Research
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Vitamin D Research Studies
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Thyroid Disorders and Treatments
- Infant Development and Preterm Care
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Congenital heart defects research
- Infant Nutrition and Health
- Stress Responses and Cortisol
- Birth, Development, and Health
- Cardiac Arrest and Resuscitation
- Nutrition, Genetics, and Disease
- Acute Myocardial Infarction Research
- Childhood Cancer Survivors' Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipid metabolism and disorders
- Obesity and Health Practices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Genetics and Neurodevelopmental Disorders
Magna Graecia University
2020-2024
Università della Svizzera italiana
2023-2024
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2014-2023
Azienda Ospedaliero Universitaria Maggiore della Carita
2019-2020
Department of Medical Sciences
2019
University of Milano-Bicocca
2018
Azienda Ospedaliera Ospedale Maggiore
2017
Piedmont University
2013
Ospedale Maggiore
2011
Background Vitamin D (25OHD) effects on glycemic control are unclear in children and adolescents with type 1 diabetes. Aims of this study were to investigate 25OHD status among T1DM its relationship insulin sensitivity status. Subjects Methods A cross sectional was carried out between 2008–2014. total 141 patients had a >12 months diagnosis enrolled the present study. Of these 35 (24.8%) migrants 106 (75.2%) Italians (T2). We retrospectively analyzed data at onset disease (T0)(64 subjects)...
Background Vitamin D status during pregnancy is related to neonatal vitamin status. deficiency has been associated with an increased risk of rickets in children and osteomalacia adults. Aim this study was investigate 25OHD levels maternal serum blood spots native migrant populations living Novara (North Italy, 45°N latitude). Methods Findings We carried out a cross sectional from April 1st 2012 March 30th 2013, tertiary Care Center. Maternal samples after delivery newborns' were analyzed for...
The hypothalamic-pituitary-adrenal (HPA) axis, and in particular cortisol, has been reported to be involved obesity-associated metabolic disturbances adults selected populations of adolescents. aim this study was investigate the association between morning adrenocorticotropic hormone (ACTH) cortisol levels cardiovascular risk factors overweight or obese Caucasian children This cross-sectional 450 adolescents (aged 4 18 years) performed a tertiary referral center. ACTH, (fasting...
Importance Deviations from international resuscitation guidelines during the management of pediatric cardiac arrest are frequent and affect clinical outcomes. An interactive tablet application (app), PediAppRREST, was developed to reduce guideline deviations arrest. Objective To assess effectiveness PediAppRREST in improving simulated in-hospital Design, Setting, Participants This multicenter 3-group simulation-based randomized trial conducted September 2020 December 2021 at 4 Italian...
Background Childhood obesity represents a major health concern worldwide due to its well established detrimental effect on cardiovascular and potential negative kidney functions. However, biomarkers that can help diagnose early stages of damage in obese children represent an unmet clinical need. Objectives In this study, we asked whether the prevalence microalbuminuria, estimated glomerular filtration rate (eGFR) or hyperuricemia recorded wide cohort adolescents would positively correlate...
Context, objective Growth hormone deficiency (GHD) is associated with insulin resistance and diabetes, in particular after treatment children adults pre-existing metabolic risk factors. Our aims were. i) to evaluate the effect on glucose metabolism of rhGH withdrawal not confirmed GHD adolescents at achievement adult height; ii) investigate impact GH receptor gene genomic deletion exon 3 (d3GHR). Design, setting We performed a longitudinal study (1 year) tertiary care center. Methods 23...
QTc evaluation in COVID-19 patients treated with chloroquine/ hydroxychloroquineIn late December 2019, a cluster of pneumonia cases caused by novel coronavirus occurred Wuhan, China, and has spread rapidly initially throughout Europe later the United States. 1 The pathogen was originally called 2019 (2019-nCoV) named severe acute respiratory syndrome 2 (SARS-nCoV-2) World Health Organization (WHO).Although most human infection linked are mild, (SARS-CoV) Middle East (MERS-CoV) were...
The aim of this study was to determine the effects a 12-month healthy lifestyle intervention based on diet plus physical activity cardiovascular structure and function in children adolescents with obesity; Methods: In longitudinal we assessed changes anthropometric, biochemical variables 55 subjects obesity (6-16 years) before after behavioral program Mediterranean exercise regimen. Subjects were divided two groups negative change BMI z-score ≥10% from baseline: weight losers (WL) non-weight...
Abstract Aim This study evaluated whether an early aggressive nutrition ( EAN ) strategy could limit extrauterine growth restriction EUGR in a cohort of preterm infants. Methods prospective nonrandomised interventional was carried out the neonatal intensive care unit Italian hospital from January 2013 to December 2015. The prevalence assessed 100 infants with gestational age ≤34 weeks, 50 after introduction regimen October 2014 and before. Results at discharge significantly lower than before...
Diffuse alveolar hemorrhage (DAH) is a clinical condition characterized by the rapid onset of dyspnea, hemoptysis and acute respiratory failure (ARF). It commonly caused autoimmune systemic vasculitis, pulmonary infections, drugs tumors. Here, we report case DAH frequent cannabis smoking. A 16-year old boy presented with hemoptysis, dyspnea ARF soon after laparoscopic surgery for varicocele in general anesthesia. The suspected diagnosis emerged from initial chest radiography, it was then...
Vitamin D is a fat-soluble vitamin that plays an important role in bone metabolism but also endowed with the capability of modulating inflammatory and immune function. Recent studies reported relationship between low levels several autoimmune diseases such as Type 1 Diabetes. regulates expression over 200 genes, related to modulation, suggesting putative these pathogenesis. This review overviews most recent advances on association increased risk Diabetes well either glucose homeostasis or...
Data on metabolic impairments in Cushing's syndrome and GH deficiency all suggest that the relationship between cortisol GH/IGF-I axis obesity may have a role related diseases. However, studies focusing only one of these hormones are often controversial paediatrics. We aimed to explore simultaneous IGF-I with alterations paediatric obesity.Retrospective cross-sectional study tertiary care center. recruited 876 (441 males 435 females) overweight obese children adolescents. A complete clinical...
Detecting bubbles in asset prices is still an open question that has attracted considerable attention recent years. This paper improves the bubble detection and dating approaches developed years by Phillips co-authors, proposing to assess plausibility of its outcomes via false discovery rate (FDR) non-discovery (FNR) based on calibrated p-values. Calibrating p-values unit root tests, applied sequentially detect bubbles, allows recovery their super-uniformity property, which crucial for a...
Background NeoTapAdvancedSupport (NeoTapAS) is a mobile application, based on screen tapping method that calculates the heart rate (HR). We aimed to evaluate accuracy of NeoTapAS in reliably determining HR from auscultation high-fidelity simulated newborn resuscitation scenario. Methods Paediatric residents assessed by plus an asphyxiated term infant scenario and orally communicated estimated HR. An external observer simultaneously documented actual set manikin Results One hundred sixty...
Patients with childhood-onset GH deficiency (GHD) are usually retested after achievement of near final height, to verify whether they need continue treatment. We investigated if stimulation test is necessary confirm a persistent status GHD or other parameters could be reliable predictor persistence.One-hundred and sixty-four children idiopathic (55 females 109 males) were when reached height using releasing hormone (GHRH)+arginine arginine alone.At diagnosis, 23.8% patients showed severe (GH...