A5065734175- Physics of Superconductivity and Magnetism
- High-pressure geophysics and materials
- Advanced Condensed Matter Physics
- Superconducting Materials and Applications
- Connective tissue disorders research
- Inorganic and Organometallic Chemistry
- Nuclear reactor physics and engineering
- Bone health and treatments
- Advanced Polymer Synthesis and Characterization
- Magnetic and transport properties of perovskites and related materials
- Neuroscience of respiration and sleep
- Magnetic properties of thin films
- Bone Metabolism and Diseases
- Vascular Anomalies and Treatments
- Sharing Economy and Platforms
- Microfluidic and Bio-sensing Technologies
- Bone and Dental Protein Studies
- Growth Hormone and Insulin-like Growth Factors
- Analytical Chemistry and Chromatography
- Photopolymerization techniques and applications
- Diet, Metabolism, and Disease
- CRISPR and Genetic Engineering
- Nuclear Physics and Applications
- Rare-earth and actinide compounds
- Thyroid Disorders and Treatments
University of Verona
2008-2024
Sapienza University of Rome
2021-2022
Accel Diagnostics (United States)
2022
Azienda Ospedaliera Ospedale Maggiore
2020
University of Pavia
2019
Carnegie Mellon University
2012-2016
University of Houston
2000-2010
Istituto Nazionale di Fisica Nucleare, Laboratori Acceleratori e Superconduttività Applicata
1994-1996
University of Milan
1994-1996
Science et Ingénierie des Matériaux et Procédés
1986
On the isolated vas deferens of guinea‐pig angiotensin potentiated strongly height contractions due to electrical stimulation hypogastric nerve; it did not affect responses noradrenaline and acetylcholine, nor elicit any contraction when given alone. Angiotensin likewise cat spleen nerve stimulation, but also induced by itself strong organ reduction venous outflow. In experiments on arterial blood pressure anaesthetized spinal cats, in which sympathetic postganglionic transmission was...
Abstract Osteogenesis imperfecta (OI) is a clinically heterogeneous heritable connective tissue disorder, characterized by low bone mass and reduced strength, which result in susceptibility to fracture deformities. In most cases it caused dominant mutations type I collagen genes, COL1A1 COL1A2. Recessive forms, collectively account for approximately 5% of osteogenesis detected North America Europe, are instead various genes coding proteins involved posttranslational modifications, folding,...
Nine tungsten bronze oxides, A6M2M'8O30 (A = Sr2+, Ba2+, or Pb2+; M Ti4+, Zr4+, Hf4+; M' Nb5+ Ta5+), have been synthesized and characterized. Although structurally very similar, the nine materials are not isostructural. The crystallize in noncentrosymmetric space groups, P4bm (no. 100) for Ba6Ti2Nb8O30, Ba6Ti2Ta8O30, Ba6Zr2Nb8O30, Ba6Zr2Ta8O30, Ba6Hf2Nb8O30, Ba6Hf2Ta8O30; Pba2 52) Sr6Ti2Nb8O30 Sr6Ti2Ta8O30; Cm2m 38) Pb6Ti2Nb8O30. All of compounds exhibit second-order nonlinear optical...
Summary Objective TSH resistance ranges from overt nonautoimmune hypothyroidism to subclinical hypothyroidism, defined as mild hyperthyrotrophinaemia but a euthyroid state clinically. To date, 23 inactivating mutations of the receptor (TSHR) gene have been proven responsible for clinical condition, an absence in TSHR has reported several cases well. In this paper, we aimed investigate actual role development both and congenital hypothyroidism. Patients 14 hypothyroid newborns, 116 subjects...
A. Gandini and P. H. Plesch, J. Chem. Soc., 1965, 4826 DOI: 10.1039/JR9650004826
Apparent mineralocorticoid excess (AME) is a rare autosomal recessive disease resulting from mutations within the hydroxysteroid (11β-dehydrogenase2 [HSD11B2]) gene causing prominent receptor activation by cortisol and hypokalemic low renin hypertension as main clinical feature. The objective of study was to characterize AME for possible novel HSD11B2 define role promoter methylation in phenotypic expression disease. Two proband brothers 10 relatives participated study. Peripheral blood...
The mortality rate for malignant melanoma (MM) is very high, since it highly invasive and resistant to chemotherapeutic treatments. modulation of some transcription factors affects cellular processes in MM. In particular, a higher expression the osteogenic master gene RUNX2 has been reported cells, compared normal melanocytes. By analyzing public databases recurrent genetic epigenetic modifications melanoma, we found that most common alteration exists upregulation is, followed by genomic...
Overexpression of the Runt-related transcription factor 2 (RUNX2) has been reported in several cancer types, and C-X-C motif chemokine receptor 4 (CXCR4) an important role tumour progression. However, interplay between CXCR4 RUNX2 melanoma cells remains poorly understood. In present study, we used a knockout (RUNX2-KO) vitro model to assess influence on protein levels along with its effects markers associated cell invasion autophagy. Osteotropism was assessed using 3D microfluidic model....
Runx2 is a transcription factor involved in melanoma cell migration and proliferation. Here, we extended the analysis of Runt domain cells to deepen understanding underlying mechanisms. By CRISPR/Cas9 system generated KO 3G8. Interestingly, proteome showed specific protein signature 3G8 related apoptosis migration, pointed out involvement neoangiogenesis process. Among proteins implicated angiogenesis identified fatty acid synthase, chloride intracellular channel protein-4, heat shock...
Abstract The ubiquitin‐proteasome system (UPS) plays an important role in maintaining cellular homeostasis by degrading a multitude of key regulatory proteins. FBXW11, also known as b‐TrCP2, belongs to the F‐box family, which targets proteins be degraded UPS. Transcription factors or associated with cell cycle can modulated may stimulate inhibit proliferation. Although FBXW11 has been investigated embryogenesis and cancer, its expression not evaluated osteogenic cells. With aim explore...
Prostaglandin D2 synthase (PGDS) (beta-trace protein) is a highly abundant cerebrospinal fluid (CSF) glycoprotein. A number of studies have been performed to determine the potential value this protein for diagnosis various neurological disorders. The measurement total PGDS levels in CSF has proved marginally useful purpose, but promising results were obtained while investigating changes posttranslational modifications (PTM) pattern. Using 2-DE analysis, we previously showed that...
Flux pinning properties and irreversibility fields Birr(T) of melt-textured YBCO with discontinuous or multiple-in-line-damage (MILD) columnar defects produced by irradiation high-energy U238 ions were studied at a constant matching field B = 10?T for several energy losses between Se 1.67 2.4?keV???1. With increasing length the MILD pins, critical current density jc(H,T) strongly increases along c axis progressively shifts upwards reaching 9?T 77?K. For 2.4?keV???1, pronounced kink is...
Abstract In the presence of eserine, isolated preparation guinea-pig vas deferens responds to electrical stimulation hypogastric nerve with enhanced contractions, which are no longer antagonised by adrenergic blocking agents but strongly inhibited atropine. Similarly, in preparations from reserpine-pretreated animals have become unresponsive stimulation, eserine elicits full-size responses almost completely abolished atropine and not affected drugs. Direct acetylcholine contracts both normal...
Abstract Over a temperature range of 32 to 20°, responses the vas deferens hypogastric stimulation at 50 shocks/sec became gradually smaller, while those 10 increased gradually. A parallel study, under same conditions, drugs known interfere with peripheral sympathetic transmission revealed marked reduction inhibitory properties adrenergic neurone blocking agents bretylium and xylocholine lower temperatures. The mechanism by which cooling modified preparation nerve as well activity on is...
West Nile virus is a zoonotic agent causing life-threatening encephalitis in proportion of infected patients. Older age, immunosuppression and mutations specific host genes (e.g. CCR5 delta-32 mutation) predispose to neuroinvasive infection. We report on two cases severe recently-treated, different-aged, chronic lymphocytic leukemia Both patients developed high-grade fever associated with neurological impairment. The younger one harboured germ-line mutation, which might have played role the...
Flavonoids may modulate the bone formation process. Among flavonoids, fisetin is known to counteract tumor growth, osteoarthritis, and rheumatoid arthritis. In addition, prevents inflammation-induced loss. order evaluate its favorable use in osteogenesis, we assayed supplementation both vitro vivo models gathered information on nanoparticle-mediated delivery of a microfluidic system. Real-time RT-PCR, Western blotting, nanoparticle synthesis were performed effects vitro, zebrafish model, ex...