A5068468571- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Sperm and Testicular Function
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Xenotransplantation and immune response
- Reproductive Biology and Fertility
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- Salivary Gland Disorders and Functions
- Pluripotent Stem Cells Research
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- interferon and immune responses
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pneumonia and Respiratory Infections
- Immune cells in cancer
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
University of Oxford
2022-2025
Kennedy Center
2025
Institute of Rheumatology
2025
Nuffield Orthopaedic Centre
2023-2024
Indian Institute of Science Education and Research, Bhopal
2013-2020
Indian Institute of Science Education and Research Kolkata
2015-2020
Indian Institute of Science Education and Research Mohali
2015-2016
Indian Institute of Science Education and Research Berhampur
2015-2016
Indian Institute of Science Education and Research, Tirupati
2015-2016
Centre for Cellular and Molecular Biology
2010-2012
Abstract RIG-I-like receptors are the key cytosolic sensors for RNA viruses and induce production of type I interferons (IFN) pro-inflammatory cytokines through a sole adaptor IFN- β promoter stimulator-1 (IPS-1) (also known as Cardif, MAVS VISA) in antiviral innate immunity. These also have pivotal role anticancer activity induction apoptosis. However, mechanism their is poorly understood. Here, we show that vaccine adjuvant, PolyIC (primarily sensed by MDA5) oncolytic virus, Newcastle...
Background Non-invasively collected samples allow a variety of genetic studies on endangered and elusive species. However due to low amplification success high genotyping error rates fewer can be identified up the individual level. Number PCRs needed obtain reliable genotypes also noticeably increase. Methods We developed quantitative PCR assay measure grade amplifiable nuclear DNA in feline faecal extracts. determined degradation experimentally aged tested suite pre-PCR protocols...
Background Water buffalo is an economically important livestock species and about half of its total world population exists in India. Development stem cell technology can find application targeted genetic modification this species. Testis has emerged as a source pluripotent cells mice human; however, not much information available buffalo. Objectives Methods Pou5f1 (Oct 3/4) transcription factor expressed by cells. Therefore, the present study, expression POU5F1 transcript protein was...
The Ro60 autoantigen is an RNA-binding protein, and a core component of nucleocytoplasmic ribonucleoprotein (RNP) complexes. essential in RNA metabolism, cell stress response pathways, cellular homeostasis. It stabilises mediates quality control dis-tribution YRNAs, retroelement transcripts, misfolded RNAs. transcriptional dysregulation or loss function can result the generation release fragments from YRNAs other small Small instigate inflammatory cascade through endosomal TLRs cytoplasmic...
Growth and development of immature testis xenograft from various domestic mammals has been shown in mouse recipients; however, buffalo xenografts have not reported to date. In this study, small fragments tissue 8-week-old calves were implanted subcutaneously onto the back immunodeficient male recipients, which either castrated or left intact (non-castrated). The retrieved analyzed 12 24 weeks later. grafted survived grew both types recipient with a significant increase weight seminiferous...
Abstract CD8 + T lymphocytes play vital roles in killing infected or deranged host cells, recruiting innate immune and regulating other aspects of responses. Like any cell, cells also produce extracellular particles. These include vesicles (EVs) non‐vesicular particles (NVEPs). cell‐derived EVs are proposed to mediate cell‐to‐cell signalling, especially the context inflammatory responses, autoimmunity, infectious diseases. supramolecular attack (SMAPs), which same size range as a component...
Human immunodeficiency virus-1 (HIV-1) which causes acquired immune deficiency syndrome (AIDS), by infecting CD4(+) cells and hence weakening the host defense mechanism till death, is one of major factor responsible for human demises worldwide. Both innate (monocytes macrophages) adaptive (T cells) expresses chemokines receptors (2 5) stromal cell derived factor-1 (SDF-1) play crucial role in HIV-1 virus entry progression. Allele variants genes CCR5 (CCR5-Δ32), CCR2 (CCR2-64I) SDF1...
A major goal of SARS-CoV-2 vaccination is the induction neutralizing antibodies (nAbs) capable blocking infection by preventing interaction Spike protein with ACE2 on target cells. Cocktails monoclonal nAbs can reduce risk severe disease if administered early in infection. However, multiple variants concern (VOCs) have arisen during pandemic that may escape from nAbs. In this issue JCI, Jia Zou, Li Li, and colleagues used yeast display libraries to identify mAbs bind proteins a vast array...
the review emphasizes key question, how natural ligands (