A5001025650- interferon and immune responses
- Immune Cell Function and Interaction
- Melanoma and MAPK Pathways
- Cytokine Signaling Pathways and Interactions
- Biosimilars and Bioanalytical Methods
- IL-33, ST2, and ILC Pathways
- Virus-based gene therapy research
- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Toxin Mechanisms and Immunotoxins
- Pediatric health and respiratory diseases
- Computational Drug Discovery Methods
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- Statistical Methods in Clinical Trials
- Synthesis of Tetrazole Derivatives
- Animal testing and alternatives
- Transgenic Plants and Applications
- RNA Interference and Gene Delivery
- Immunotoxicology and immune responses
- NF-κB Signaling Pathways
- Amyotrophic Lateral Sclerosis Research
- Hemophilia Treatment and Research
Healthcentric Advisors
2024
Archemix (United States)
2005-2023
Tris Pharma (United States)
2018
Novartis (United States)
2016-2018
Novartis (Switzerland)
2010-2012
The Ohio State University
2000-2008
Millennium Engineering and Integration (United States)
2002-2004
Roswell Park Comprehensive Cancer Center
2000
Vertex Pharmaceuticals (United States)
2000
Nationwide Children's Hospital
2000
The ability of interleukin (IL)-12 to prevent tumors when administered individuals with a genetic risk cancer was studied in two lines transgenic mice expressing rat HER-2/neu oncogene the mammary gland. Female BALB/c (H-2d) carrying activated HER-2/ neu show no morphological abnormalities gland until 3 wk age. They then progress through atypical hyperplasia situ lobular carcinoma and at 33 age all 10 glands display invasive carcinomas. Adult FVB (H-2q) protooncogene develop carcinomas...
We investigated the effects of IL-12 on a murine model allergic lung inflammation. Administration was timed to interfere with either sensitization (early dosage) or hypersensitivity inflammatory response in (late dosage), both and late dosages). Comparisons IL-12- PBS-treated animals within each treatment group revealed several noticeable IL-12. Early dosage, combination early dosages, strikingly decreased ragweed-specific serum IgE, tracheal ring reactivity acetylcholine, BAL eosinophilia...
The mechanism of cytokine-induced shock remains poorly understood. combination IL-2 and IL-12 has synergistic antitumor activity in vivo, yet been associated with significant toxicity. We examined the effects plus a murine model found that daily, simultaneous administration resulted 100% mortality within 4 to 12 days depending on strain employed. Mice treated exhibited NK cell apoptosis, pulmonary edema, degenerative lesions gastrointestinal tract, elevated serum levels proinflammatory...
Recombinant human interleukin-11 (rhIL-11) is a multifunctional cytokine that can reduce inflammation through the downregulation of multiple pro-inflammatory mediators from activated macrophages. rhIL-11 also inhibits production several immunostimulatory cytokines such as IL-12 and interferon gamma (IFN-gamma) has shown biological activity in animal models inflammatory disease consistent with immunomodulatory effects on macrophages T cells. To further elucidate anti-inflammatory vivo, effect...
Abstract We hypothesized that IFN-α would enhance the apoptotic activity of bortezomib on melanoma cells. Combined treatment with and induced synergistic apoptosis in other solid tumor cell lines. Apoptosis was associated processing procaspase-3, procaspase-7, procaspase-8, procaspase-9 cleavage Bid poly(ADP-ribose) polymerase. Bortezomib plus effective at inducing cells overexpressed Bcl-2 or Mcl-1, suggesting this combination can overcome mitochondrial pathways survival resistance to...
Acetaminophen intoxication results in hepatotoxicity associated with increased serum concentrations of hepatocellular leakage enzymes such as aspartate aminotransferase, lactate dehydrogenase, and alanine centrilobular degeneration necrosis, activation Kupffer cells. Recombinant human Interleukin-11 (rhIL-11) downregulates the production proinflammatory mediators from activated macrophages has direct effects on hepatocyte gene expression. Based these biological activities rhIL-11, effect...
A long-term study was conducted in rats to assess the contribution of surface area CoCrMo devices carcinogenesis. Groups consisting 104 each (52 male, 52 female) were either implanted with metal cylinders fixed on left, lateral femur (groups 1–3) or injected a suspension microspheres dorsal subcutis (group 4). Group 1 (control) received solid Ti6Al4V [surface body weight (SA/BW) ratio measuring 1.35 times that human total hip prosthesis (HTHP)]. 2 (SA/BW ratio: identical implants group 1). 3...
Click to increase image sizeClick decrease sizeAsthma Il-12 Th1 Th2 Eosinophils Ifn-GAMMA
A high incidence of hemangiosarcoma (HSA) was observed in mice treated for 2 years with siponimod, a sphingosine-1-phosphate receptor 1 (S1P1) functional antagonist, while no such tumors were rats under the same treatment conditions. In 3-month rat (90 mg/kg/day) and 9-month mouse (25 75 vivo mechanistic studies, vascular endothelial cell (VEC) activation both species, but VEC proliferation persistent increases circulating placental growth factor (PLGF2) only seen mouse. mice, these effects...
PARVAX is a genetic vaccine platform based on an adeno-associated vector that has demonstrated to elicit potent, durable, and protective immunity in nonhuman primates (NHPs) after single dose. Here, we assessed immunogenicity following prime-boost regimen against SARS-CoV-2. In mice, low-dose prime followed by higher-dose boost elicited potent neutralizing antibody responses distinct cross-reactivity profiles, depending the antigen used booster vaccine. However, anti-vector developed mice...
Abstract Background Frontotemporal dementia (FTD) presents with a change in personality, behaviour and language is the second most common cause of young‐onset after Alzheimer’s disease. Loss function mutations GRN , encoding progranulin (PGRN), causes FTD heterozygous state, accounting for 5‐10% all cases. PGRN essential normal lysosomal neuronal survival. The reduction observed FTD‐GRN patients leads to dysfunction, associated mis‐accumulation TDP‐43 exaggerated microglial reactivity that...