A5019538773- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Gut microbiota and health
- Cardiac Arrhythmias and Treatments
- Mitochondrial Function and Pathology
- Biochemical Analysis and Sensing Techniques
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Mechanical Circulatory Support Devices
- Antioxidant Activity and Oxidative Stress
- Dietary Effects on Health
- Protease and Inhibitor Mechanisms
- Pain Mechanisms and Treatments
- Polyamine Metabolism and Applications
- Receptor Mechanisms and Signaling
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Cardiac Fibrosis and Remodeling
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Fuel Cells and Related Materials
- Cardiac Ischemia and Reperfusion
Loyola University Chicago
2020-2024
Vifor Pharma (Switzerland)
2023
Loyola University Medical Center
2021
Northwestern University
2018-2020
Cardiovascular Institute of the South
2018
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2016
Discovery Institute
2016
Duke University
2016
University of Cologne
2016
Sanford Burnham Prebys Medical Discovery Institute
2012-2016
Background— Significant evidence indicates that the failing heart is energy starved. During development of failure, capacity to utilize fatty acids, chief fuel, diminished. Identification alternate pathways for myocardial fuel oxidation could unveil novel strategies treat failure. Methods and Results— Quantitative mitochondrial proteomics was used identify metabolic derangements occur during cardiac hypertrophy failure in well-defined mouse models. As expected, amounts proteins involved acid...
Background: Mutations in desmoplakin ( DSP ), the primary force transducer between cardiac desmosomes and intermediate filaments, cause an arrhythmogenic form of cardiomyopathy that has been variably associated with right ventricular cardiomyopathy. Clinical correlates have limited to small case series. Methods: genetic data were collected on 107 patients pathogenic mutations 81 plakophilin 2 PKP2 ) as a comparison cohort. A composite outcome severe arrhythmia was assessed. Results: cohorts...
Chronic exposure to glucocorticoid hormones, resulting from either drug treatment or Cushing's syndrome, results in insulin resistance, central obesity, and symptoms similar the metabolic syndrome. We hypothesized that major effects of corticosteroids are mediated by changes key enzyme adenosine monophosphate-activated protein kinase (AMPK) activity. Activation AMPK is known stimulate appetite hypothalamus catabolic processes periphery. assessed activity expression several enzymes...
Significance The increase in obesity has been accompanied by a rise the prevalence of peripheral neuropathy. Because there is no disease-modifying therapy, paradigm-shifting research on pain associated with obesity, metabolic syndrome, and type 2 diabetes urgently needed. Our data suggest that fecal transplantation from lean to obese, insulin-resistant mice decreases obesity-induced hypersensitivity increases nerve density skin. These improvements are changes system gene expression...
The vagus nerve provides a direct line of communication between the gut and brain for proper regulation energy balance glucose homeostasis. Short-chain fatty acids (SCFAs) produced via microbiota fermentation dietary fiber have been proposed to regulate host metabolism feeding behavior nerve, but molecular mechanisms not yet elucidated. We sought identify G-protein-coupled receptors within vagal neurons that mediate physiological therapeutic benefits SCFAs. SCFA, particularly propionate,...
More than 50% of patients with heart failure present preserved ejection fraction (HFpEF), and 80% them are overweight or obese. In this study we developed an obesity associated pre-HFpEF mouse model showed improvement in both systolic diastolic early dysfunction following fecal microbiome transplant (FMT). Our suggests that the gut microbiome-derived short-chain fatty acid butyrate plays a significant role improvement. Cardiac RNAseq analysis to significantly upregulate ppm1k gene encodes...
Polyamines are critical cellular components that regulate a variety of processes, including translation, cell cycling, and nucleic acid metabolism. The polyamines, putrescine, spermidine, spermine, found abundantly within cells positively-charged at physiological pH. Polyamine metabolism is connected to distinct other metabolic pathways, nucleotide amino However, the breadth effect polyamines on remains be fully understood. We recently demonstrated role for in cholesterol metabolism,...
ABSTRACT Obesity is an epidemic, and it characterized by a state of low-grade systemic inflammation. A key component inflammation the activation inflammasomes, multiprotein complexes that form in response to danger signals lead caspase-1. Previous studies have found Westernized diet induces inflammasomes production inflammatory cytokines. Gut microbiota metabolites, including short-chain fatty acid butyrate, received increased attention as underlying some obesogenic features, but mechanisms...
The adult myocardium relies on oxidative metabolism. In ischemic myocardium, such as the embryonic heart, glycolysis contributes more prominently a fuel source. sulfonylurea receptor 2 (SUR2) was previously implicated in normal myocardial transition from glycolytic to metabolism that occurs during adaptation postnatal life. This now selectively deleted mouse resulting protection ischemia reperfusion injury. SUR2-deleted cardiomyocytes had enhanced glucose uptake, and SUR2 forms complex with...
Metabolic disorders such as obesity and type 2 diabetes (T2D) are increasingly prevalent worldwide, necessitating a deeper comprehension of their underlying mechanisms. However, translating findings from animal research to human patients remains challenging. This study aimed investigate the long-term effects Streptozotocin (STZ) on metabolic, cardiac, somatosensory function in mice fed Western diet (WD) high fat, sucrose, cholesterol with low doses STZ administration compared WD alone. In...
<b><i>Introduction:</i></b> Mitochondria are essential organelles required for several cellular processes ranging from ATP production to cell maintenance. To provide energy, mitochondria transported specific areas in need. also need be recycled. These mechanisms rely heavily on trafficking events. While still unclear, hypothalamic linked obesity. <b><i>Methods:</i></b> We used C2 domain protein 5 (C2CD5, called domain-containing phosphoprotein...
Abstract Obesity is a current epidemic, affecting millions of individuals worldwide. Chronic obesity characterized by low-grade systemic inflammation besides not being classic inflammatory disease. Many studies have tried to identify insults dysregulated Westernized diet – consisted high fat, sucrose, and cholesterol –mainly focusing on production secretion cytokines. The gut microbiome derived metabolites, including the short-chain fatty acid butyrate, received increased attention as...
Objective: We examined the effects of SGLT2 inhibition with Dapagliflozin (DAPA) on left ventricular ejection fraction (LVEF) and cardiomyocyte regeneration in mice after myocardial infraction (MI), a model for Heart Failure reduced EF. Introduction: Neonatal can regenerate cardiomyocytes, but this ability is lost shortly birth due part to switch from anaerobic glycolysis fatty acid utilization. This pyruvate dehydrogenase kinase 4 (PDK-4) (PDH) dependent glycolysis. Empagliflozin use MI...
More than 50% of patients with heart failure are diagnosed preserved ejection fraction (HFpEF), and 80% them obese. It is a prominent disease no available treatments. characterized by diastolic dysfunction that involves increase in left ventricle stiffness decrease its relaxation during diastole. To better understand the pathogenesis obesity associated HFpEF, our studies focus on early asymptomatic changes cardiac mechanics occurs before increases intracardiac pressure. Therefore, we have...