A5102001007- Calcium signaling and nucleotide metabolism
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Lipid Membrane Structure and Behavior
- Adenosine and Purinergic Signaling
- Hemoglobin structure and function
- Biochemical and Structural Characterization
- Sirtuins and Resveratrol in Medicine
- Glycosylation and Glycoproteins Research
- Ion channel regulation and function
- Protein Tyrosine Phosphatases
- Tryptophan and brain disorders
- Ion Channels and Receptors
- Galectins and Cancer Biology
Universität Hamburg
2017-2021
University Medical Center Hamburg-Eppendorf
2017-2021
McGill University Health Centre
2004
Vollum Institute
2003
University of Geneva
1997-2000
The University of Queensland
1997
A protein that enables the activation of ryanodine receptors by NAADP in T cells is identified.
In the present paper, we show that transport from early to late endosomes is inhibited at restrictive temperature in a mutant CHO cell line (ldlF) with ts-defect ε coatomer protein (εCOP), although internalization and recycling continue. Early then appear like clusters of thin tubules devoid typical multivesicular regions, which are normally destined become vesicular intermediates during endosomes. We also find vitro formation these vesicles BHK donor cytosol prepared ldlF cells incubated...
Coat proteins of the COP family were recently shown by us and others to be involved in membrane transport endocytic pathway, addition their known functions biosynthetic pathway. We have also that association endosomal COPs depends on acidic pH, contrast COPs. In this paper, we report both recruitment vitro biogenesis intermediates destined for late endosomes, depend a cytosolic factor, which identified as small GTP-binding protein ARF1. Our data indicate ARF1 does not act via activation an...
The enzymes DUOX1 and DUOX2 may mediate rapid then sustained NAADP production to promote Ca 2+ signaling in T cells.
Aging | doi:10.18632/aging.203766. Vera Gorbunova, Marcus Buschbeck, Xiaolu A. Cambronne, Karthikeyani Chellappa, Daniela Corda, Juan Du, Marc Freichel, Jonathan Gigas, Alexander E. Green, Feng Gu, Iva Guberovic, Aravinthkumar Jayabalan, Imrankhan Khansahib, Sarmistha Mukherjee, Andrei Seluanov, Matthew Simon, Lars J. Sverkeli, Nora Kory, Daniel C. Levine, Ivan Matic, Andrey Nikiforov, Johannes G.M. Rack, Shin-Ichiro Imai, David Sinclair, Debra Toiber, Yongjuan Zhao, Raul Mostoslavsky, Lee...