A5101709317- Composite Structure Analysis and Optimization
- Conducting polymers and applications
- Enzyme Production and Characterization
- Protein Hydrolysis and Bioactive Peptides
- Organic Electronics and Photovoltaics
- Vibration and Dynamic Analysis
- Glycosylation and Glycoproteins Research
- Metabolism and Genetic Disorders
- Pesticide Exposure and Toxicity
- Carbohydrate Chemistry and Synthesis
- Synthesis and biological activity
- Perovskite Materials and Applications
- Genomics, phytochemicals, and oxidative stress
- Analytical Chemistry and Chromatography
- Phytase and its Applications
- Electrochemical Analysis and Applications
- Advanced Glycation End Products research
- Numerical methods in engineering
- Structural Analysis and Optimization
- Adipose Tissue and Metabolism
- Enzyme Catalysis and Immobilization
- Advanced Sensor and Energy Harvesting Materials
- Protease and Inhibitor Mechanisms
- Analytical Chemistry and Sensors
- Graphene research and applications
University of Bath
2024
Indian Institute of Technology Roorkee
1989-2024
Chandigarh University
2024
Shree Guru Gobind Singh Tricentenary University
2024
Institute of Microbial Technology
2021-2023
Academy of Scientific and Innovative Research
2016-2023
Council of Scientific and Industrial Research
2016-2023
Amity University
2019-2023
Universidade de São Paulo
2022
University of North Carolina at Chapel Hill
2022
Administration of natural or synthetic agents to inhibit, delay, block, reverse the initiation and promotional events associated with carcinogenesis opens a new avenue for cancer prevention treatment reduce morbidity mortality. Eugenol, potential chemopreventive agent, is component clove several other spices such as basil, cinnamon, bay leaves. A number reports have shown that eugenol possesses antiseptic, analgesic, antibacterial, anticancer properties. The present study was undertaken...
Abstract A new class of pyridyl benzimdazole based Ru complex decorated polyaniline assembly (PANI-Ru) was covalently grafted onto reduced graphene oxide sheets (rGO) via covalent functionalization approach. The attachment PANI-Ru with rGO confirmed from XPS analysis and Raman spectroscopy. chemical bonding between induced the electron transfer to backbone conjugated PANI chain. resultant hybrid metallopolymer successfully demonstrated as an donor in bulk heterojunction polymer solar cells...
Many of the anti-cancer agents currently used have an origin in natural sources including plants. Aloe vera is one such plant being studied extensively for its diverse health benefits, cancer prevention. In this study, cytotoxic potential crude extract (ACE) alone or combination with cisplatin human breast (MCF-7) and cervical (HeLa) cells was by cell viability assay, nuclear morphological examination cycle analysis. Effects were correlated modulation expression genes involved regulation,...
Invasion and metastasis are the major causes of cancer-related death. Pharmacological or therapeutic interventions such as chemoprevention progression stages neoplastic development could result in substantial reduction incidence cancer mortality. (-)-Epigallocatechin-3-gallate (EGCG), a promising chemopreventive agent, has attracted extensive interest for therapy utilizing its antioxidant, anti- proliferative inhibitory effects on angiogenesis tumor cell invasion. In this study, we assessed...
Sulforaphane (SFN) may hinder carcinogenesis by altering epigenetic events in the cells; however, its molecular mechanisms are unclear. The present study investigates role of SFN modifying human cervical cancer cells, HeLa. HeLa cells were treated with (2.5 µ M) for a period 0, 24, 48, and 72 hours all experiments. After treatment, expressions DNMT3B, HDAC1, RAR β , CDH1, DAPK1, GSTP1 studied using RT-PCR while promoter DNA methylation tumor suppressor genes (TSGs) was MS-PCR. Inhibition...
The present study demonstrates the production and thrombolytic potential of a novel thermostable thiol-dependent fibrinolytic protease by Bacillus cereus RSA1. Statistical optimization different parameters was accomplished with Plackett–Burman design validated further central composite 30.75 U/mL production. Precipitation chromatographic approaches resulted in 33.11% recovery 2.32-fold purification. molecular weight 40 KDa it exhibited broad temperature pH stability range 20–80 °C 5–10...
Microbial keratinases exhibit a momentous role in converting keratin biowastes into exceedingly valuable protein supplements. This study reports novel, highly stable keratinase from Bacillus pacificus RSA27 for the production of pure peptides rich essential amino acids chicken feathers. Purified showed specific activity 38.73 U/mg, 2.58-fold purification, and molecular weight 36 kDa. Kinetic studies using feather as substrate report Km Vmax values 5.69 mg/ml 142.40 μg/ml/min, respectively,...
The present study was designed to gain insight into the antiproliferative activity of ethanolic neem leaves extract (ENLE) alone or in combination with cisplatin by cell viability assay on human breast (MCF-7) and cervical (HeLa) cancer cells. Nuclear morphological examination cycle analysis were performed determine mode death. Further, identify its molecular targets, expression genes involved apoptosis, progression, drug metabolism analyzed RT-PCR. Treatment MCF-7, HeLa, normal cells ENLE...
Phytochemicals are among the natural chemopreventive agents with most potential for delaying, blocking or reversing initiation and promotional events of carcinogenesis. They therefore offer cancer treatment strategies to reduce related death. One such promising agent which has attracted considerable attention is sulforaphane (SFN), exhibits anti-cancer, anti-diabetic, anti-microbial properties. The present study was undertaken assess effect SFN alone in combination a chemotherapeutic agent,...
Background. The concept of combination chemoprevention holds great potential for cancer management as lower, clinically tolerable doses individual agents could be achieved through therapeutic synergy. However, elucidation their possible interactions—additive, synergistic, or antagonistic—must thoroughly studied before considering clinical use. Methods. To evaluate the effect treatment sulforaphane (SFN) and eugenol on HeLa cells, authors performed cell viability assay, apoptosis reverse...
This study employs candlestick patterns and sequence similarities to forecast trends in time-series stock data. Time-series financial forecasting is a crucial component risk management portfolio optimization. Finding suitable technique for engineering poses challenge since it must meet the criteria of being transparent, robust, compatible. There more multi-modal data used research, prediction algorithms are getting harder understand making move smoothly. Candlestick methods expected be...
The ultrafast charge dynamics demonstrated in the Au–CdS film supports plasmon induced interfacial transfer transition phenomenon.
Microbial fibrinolytic proteases are therapeutic enzymes responsible to ameliorate thrombosis, a fatal cardiac-disorder which effectuates due excessive fibrin accumulation in blood vessels. Inadequacies such as low specificity, lethal after-effects and short life-span of available stimulates an intensive hunt for novel, efficient safe substitutes. Therefore, we herewith suggest novel potent enzyme RFEA1 from Bacillus cereus RSA1 ( MK288105 ). Although, attributes in-vitro purification,...