A5063345624- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Antioxidant Activity and Oxidative Stress
- Liver Disease Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Eicosanoids and Hypertension Pharmacology
- Nutritional Studies and Diet
- Diet and metabolism studies
- Tea Polyphenols and Effects
- Hormonal Regulation and Hypertension
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Retinoids in leukemia and cellular processes
- Lipid metabolism and biosynthesis
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Free Radicals and Antioxidants
National Defense Medical College
2013-2024
National Defense Medical College Hospital
2008-2024
Japan Small Animal Medical Center
2020
Chubu University
2016
Jikei University School of Medicine
2010
Kao Corporation (Japan)
2010
Nagoya City University
2007
Juntendo University
2003
Background Endothelial dysfunction is an independent predictor for cardiovascular events in patients with type 2 diabetes ( T2DM ). Glucagon like peptide‐1 GLP ‐1) reportedly exerts vasodilatory actions, and inhibitors of dipeptidyl peptidase‐4 DPP ‐4), enzyme‐degrading ‐1, are widely used to treat . We therefore hypothesized that ‐4 ‐4Is) improve endothelial function performed prospective, randomized crossover trials compare the ‐4I sitagliptin α‐glucosidase inhibitor, voglibose (in study...
Association of habitual coffee consumption with coronary heart disease morbidity and mortality has not been established. We hypothesized that may enhance reverse cholesterol transport (RCT) as the antiatherogenic properties high-density lipoprotein (HDL).This study was to investigate whether phenolic acids regulates RCT from macrophages in vitro, ex vivo vivo.Caffeic acid ferulic acid, major coffee, enhanced efflux THP-1 mediated by HDL, but apoA-I. Furthermore, these increased both mRNA...
Objective— ATP-binding cassette transporter A1 (ABCA1) and ABCG1 are key molecules in an initial step of reverse cholesterol transport (RCT), a major antiatherogenic property high-density lipoprotein (HDL). The ubiquitin-proteasome system (UPS) mediates nonlysosomal pathways for protein degradation is known to be involved atherosclerosis. However, little about the effects UPS on these overall RCT. We therefore investigated whether inhibition affects ABCA1/G1 expression macrophages RCT vitro...
Osteopontin (OPN) is a noncollagenous adhesion protein found at the site of atherosclerotic lesions. However, it has not yet been clarified whether or OPN can promote METHODS AND RESULTS We investigated contribution to atherosclerosis by evaluating aortic sinus lesions both transgenic (Tg) and non-Tg mice fed an atherogenic diet (1.25% cholesterol) for 16 weeks. The were be significantly larger in OPN-Tg compared with those (17,859+/-2010 versus 6469+/-485 micro m(2), P<0.01). fatty-streak...
Although the anti-inflammatory effect of interleukin-1 (IL-1) receptor antagonist (IL-1Ra) has been described, contribution this cytokine to cholesterol metabolism remains unclear. Our aim was ascertain whether deficiency IL-1Ra deteriorates upon consumption an atherogenic diet. IL-1Ra-deficient mice (IL-1Ra-/-) showed severe fatty liver and portal fibrosis containing many inflammatory cells following 20 weeks diet when compared with wild type (WT) mice. Expectedly, levels total in IL-1Ra-/-...
ATP-binding cassette transporters (ABC) A1 and G1 are key molecules in cholesterol efflux from macrophages, which is an initial step of reverse transport (RCT), a major anti-atherogenic property high-density lipoprotein (HDL). Astaxanthin one the naturally occurring carotenoids responsible for pink-red pigmentation variety living organisms. Although astaxanthin known to be strong antioxidant, it remains unclear through what mechanism action affects homeostasis macrophages. We therefore...
Apolipoprotein (apo) A-I is a major high-density lipoprotein (HDL) protein that causes cholesterol efflux from peripheral cells through the ATP-binding cassette transporter A1 (ABCA1), thus generating HDL and reversing macrophage foam cell phenotype. Pre-β1 smallest subfraction of HDL, which believed to represent newly formed it most active acceptor free cholesterol. Furthermore has possible protective function against cardiovascular disease (CVD). We developed novel apoA-I mimetic peptide...
Aim: The ATP binding cassette transporters A1 and G1 (ABCA1/G1) scavenger receptor class B type I (SR-BI) are key molecules in cholesterol efflux atherogenesis. These genes regulated by peroxisome proliferator-activated γ (PPARγ) liver X (LXR). Telmisartan is an angiotensin 1 blocker which has been reported to act as a ligand for PPARγ. We investigated whether PPARγ-activating ARBs affect the expression of these from macrophages.Methods Results: increased ABCA1, ABCG1 SR-BI mRNA levels THP-1...
Endothelin-1 (ET-1) contributes to the pathogenesis of cardiovascular diseases with multiple properties such as vasoconstriction. Human ET-1 gene expression is up-regulated by transcription factor hypoxia-inducible factor-1 (HIF-1) through hypoxia response element (HRE). Although previous studies suggested that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) alter HIF-1-related expression, it remained unclear whether statins modulate HIF-1-mediated expression. Therefore,...
The ATP-binding cassette transporter-A1 (ABCA1) regulates cholesterol efflux from cells and is involved in high-density lipoprotein metabolism atherogenesis. objective of this study was to investigate the effect dexamethasone (Dex) other glucocorticoid receptor (GR) ligands on apolipoprotein AI-mediated macrophages ABCA1 expression them.Dex, a GR agonist, decreased mRNA levels dose- time-dependent fashion, RU486, antagonist, reversed inhibitory Dex. effects Dex RU486 protein were consistent...
ATP-binding cassette transporter A1 (ABCA1) is a rate-limiting factor for high-density lipoprotein (HDL) biogenesis. The ABCA1 gene expression known to be upregulated by various transcriptional factors. However, negative regulation factors would better targets pharmacological modulation of HDL Doxazosin, an alpha(1)-adrenoceptor blocker, increased mRNA, its protein, and apolipoprotein A-I-mediated biogenesis in THP-1 macrophages CHO-K1 cells, independent blockade. Analysis the human promoter...
Experimental studies of human atherogenesis require an appropriate animal model that mimics physiology and pathology. Because swine is similar to physiology, we developed a hyperlipidemia-induced atherosclerosis using the recently world's smallest Microminipig(TM).These animals weigh only 5kg at 3months age, much smaller than any other miniature pig. We found administration high-fat/high-cholesterol diet containing least 0.2% cholesterol without cholic acid for as little eight weeks induces...
Insulin signaling comprises 2 major cascades: the insulin receptor substrate/phosphatidylinositol 3'-kinase/protein kinase B and Ras/Raf/mitogen-activated protein kinase/kinase/ERK pathways. While many studies on tissue-specific effects of 3' -kinase/protein pathway have been conducted, role other cascade in resistance has not investigated. High glucose/fatty acid toxicity, inflammation, oxidative stress, all which are associated with resistance, can activate ERK. The liver plays a central...
Recent studies reported that low high-density lipoprotein (HDL)-mediated cholesterol efflux capacity rather than HDL (HDL-C) is strongly associated with the increased risk for coronary artery disease. It remains unclear whether exercised-based cardiac rehabilitation (CR) can increase capacity.This study a retrospective analysis of stored serum from patients acute syndrome (ACS) who participated in outpatient CR program following successful percutaneous intervention. We employed cell-based...