A5102757525- Drug Transport and Resistance Mechanisms
- Analytical Methods in Pharmaceuticals
- 3D Printing in Biomedical Research
- Drug Solubulity and Delivery Systems
- Pharmacological Effects and Toxicity Studies
- Analytical Chemistry and Chromatography
- Plant Stress Responses and Tolerance
- Cancer Research and Treatments
- Bioactive natural compounds
- Metabolism, Diabetes, and Cancer
- Ginseng Biological Effects and Applications
- Plant Gene Expression Analysis
- Amino Acid Enzymes and Metabolism
- Rice Cultivation and Yield Improvement
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects of Natural Compounds
- Plant nutrient uptake and metabolism
- Biological and pharmacological studies of plants
- Nanoparticle-Based Drug Delivery
- Ion Transport and Channel Regulation
- Diet and metabolism studies
- Pharmacogenetics and Drug Metabolism
- Bipolar Disorder and Treatment
- Pancreatic function and diabetes
- Plant Molecular Biology Research
Southern Medical University
2020-2023
Guilin Medical University
2023
Guangzhou Medical University
2023
Fujian Agriculture and Forestry University
2022
Abstract WRKY transcription factors (TFs) play crucial roles in biotic and abiotic stress responses. However, their thermal response are still largely elusive, especially rice. In this study, we revealed the functions of WRKY10 TF VQ8 protein containing VQ motif rice thermotolerance. Overexpression or loss function increases thermosensitivity, whereas conversely, overexpression enhances accelerates reactive oxygen species (ROS) accumulation chloroplasts apoplasts, it also induces expression...
Objectives The blocking effect of S-carvedilol (S-CAR) on the beta-adrenoceptor is about 100 times stronger than that right-handed conformation. However, further development restricted because its poor bioavailability caused by low solubility and high first-pass effect. In study, S-CAR self-microemulsifying drug-delivery systems (SMEDDSs) were established, effects different lipid materials absorption metabolism investigated.Methods Six kinds with chemical structures including oleic acid,...
With the widespread clinical use of drug combinations, incidence drug-drug interactions (DDI) has significantly increased, accompanied by a variety adverse reactions. Drug transporters play an important role in development DDI affecting elimination process drugs vivo, especially pathological state. Tubulointerstitial fibrosis (TIF) is inevitable pathway progression chronic kidney disease (CKD) to end-stage renal disease. Here, dynamic expression changes eleven TIF have been systematically...
(S)-carvedilol (S-CAR) is the dominant pharmacodynamic conformation of carvedilol, but its further development for extended-release formulation restricted by poor solubility. This study aimed to prepare and screen S-CAR salts that could be used improve solubility allow extended release. Five with well-known acid counterions (i.e., phosphate, hydrochloride, sulfate, fumarate, tartrate) were produced using similar processes. However, these obtained water contents 1.60–12.28%, their...
Abstract High cell-density cultivation (HCDC) is fundamental to basic research and industrial applications, especially in batch mode. However, limited media are available for culture of HCDC, because the must contain extremely sufficient nutrients on one hand few or even no substrates generate detrimental metabolite other attain HCDC. Spirulina platensis (SP), a new material, considered ideal development such media. Here, we develop biolysis method SP degradation based supernatant Bacillus...