A5102791910- Infant Nutrition and Health
- Gut microbiota and health
- Urinary Tract Infections Management
- Neonatal Respiratory Health Research
- Neonatal and Maternal Infections
- Infant Development and Preterm Care
- Clostridium difficile and Clostridium perfringens research
- Breastfeeding Practices and Influences
- Birth, Development, and Health
- Nosocomial Infections in ICU
- Diet and metabolism studies
- Pediatric Urology and Nephrology Studies
- Infant Health and Development
- Streptococcal Infections and Treatments
- Neonatal Health and Biochemistry
- Food Allergy and Anaphylaxis Research
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Digestive system and related health
- Child Nutrition and Feeding Issues
- Asthma and respiratory diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Anesthesia and Neurotoxicity Research
- Bacterial Infections and Vaccines
- Eosinophilic Esophagitis
Central University Hospital of Asturias
2014-2024
Instituto de Investigación Sanitaria del Principado de Asturias
2017-2024
Disturbances in the early establishment of intestinal microbiota may produce important implications for infant's health and risk disease later on. Different perinatal conditions be affecting development gut microbiota. Some them, such as delivery mode or feeding habits, have been extensively assessed whereas others remain to studied, being critical identify their impact on and, if any, minimize it. Antibiotics are among drugs most frequently used life, use intrapartum antimicrobial...
Background: The microbial colonization of the neonatal gut provides a critical stimulus for normal maturation and development. This process early microbiota establishment, known to be affected by several factors, constitutes an important determinant later health. Methods: We studied establishment in preterm full-term infants impact perinatal antibiotics upon this premature babies. To end, 16S rRNA gene sequence-based assessment was performed at phylum level functional inference analyses were...
The establishment of the gut microbiota poses implications for short and long-term health. Bifidobacterium is an important taxon in early life, being one most abundant genera infant intestinal carrying out key functions maintaining host-homeostasis. Recent metagenomic studies have shown that different factors, such as gestational age, delivery mode, or feeding habits, affect at high phylogenetic levels. However, their impact on specific bifidobacterial populations not yet well understood....
The involvement of the gut microbiota on weight-gain and its relationship with childhood undernutrition growth has been reported. Thus, constitutes a potential therapeutic target for preventing impairment. However, our knowledge in this area is limited. In study we aimed at evaluating among early microbiota, growth, development preterm infants. To end assessed levels specific microorganisms by qPCR, those short chain fatty acids mean gas-chromatography, feces from 63 newborns determined...
Postnatal growth restriction has high prevalence in very low birth weight (VLBW) preterm neonates, and this could affect their long-term prognosis. Nowadays, there is no consensus on how to monitor these neonates. Objective: This study aimed compare of intra- extrauterine (IUGR EUGR) a sample VLBW infants according the Fenton 2013 charts INTERGROWTH-21st (IW-21) standards analyze concordance between both different EUGR definitions criteria (cross-sectional, dynamic, true). Patients Methods:...
Abstract Objective Analyze fecal and blood samples at point of diagnosis in IgE mediated cow's milk protein allergy (CMPA) non‐IgE (NIM)‐CMPA patients to look for potential new biomarkers. Patients Methods Fourteen with CMPA 13 NIM‐CMPA were recruited three hospitals the north Spain, compared 25 infants from a control group same age range. To characterize intestinal microbiota, 16S rDNA gene internal transcribed spacer amplicons bifidobacteria sequenced Illumina technology. Fatty acids...
Abstract Multiple criteria and growth references have been proposed for extrauterine restriction (EUGR). We hypothesized that these may impact the diagnosis of EUGR. The objective was to evaluate prevalence EUGR with its different definitions concordance according Fenton, Olsen, INTERGROWTH-21st in very-low-birthweight (VLBW) infants. This is an observational, retrospective, multicenter study including VLBW infants from Spanish SEN1500 Network 2011 2020. Patients major congenital anomalies,...
Abstract Context Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring. Objective The aim of this study was to assess the impact serum free T4 on psychomotor development Materials and methods involved 147 women third trimester (week 37) pregnancy. TSH levels were measured at 37 week gestation. children evaluated between 38 60 months age by McCarthy Scales Children's Abilities. Results 54.4% had a...
Correct establishment of the gut microbiome is compromised in premature babies, with Bifidobacterium being one most affected genera. Prematurity often entails inability to successfully breastfeed, therefore requiring implementation other feeding modes; breast milk expression from a donor mother recommended option when their own mother’s not available. Some studies showed different microbial profiles infants fed and human milk, however, it known how this affects species composition genus...
Antibiotics are important disruptors of the intestinal microbiota establishment, linked to immune and metabolic alterations. The intrapartum antibiotics prophylaxis (IAP) is a common clinical practice that present in more than 30% labours, known negatively affect gut composition. However, little about how it affects Bifidobacterium (sub)species level, which one most microbial genera early life. This study presents qualitative quantitative analyses bifidobacterial populations faecal samples,...
The microbial colonization of the intestine during first months life constitutes most important process for microbiota-induced host-homeostasis. Alterations in this may entail a high-risk disease later life. However, potential factors affecting infant are not well known. Moreover, impact orally administered vaccines upon establishing microbiome remains unknown. Here we assessed intestinal establishment and evaluated rotavirus vaccination process. Metagenomic, PCR-DGGE faecal short chain...
The early life gut microbiota has been reported to be involved in neonatal weight gain and later infant growth. Therefore, this may constitute a target for the promotion of healthy growth development with potential consequences life. Unfortunately, we are still far from understanding association between In context, evaluated relationship cohort full-term infants. absolute levels specific fecal microorganisms were determined 88 vaginally delivered 36 C-section-delivered newborns at 1 month...
Background and objectives: Variable diagnostic criteria growth charts have been used for extrauterine restriction (EUGR). The objective was to assess the prevalence concordance of EUGR in extremely-low-birthweight (ELBW) infants with most frequent charts. Materials methods: An observational, retrospective multicenter study conducted from 2011 2020 including ELBW Spanish SEN1500 Network. calculated at discharge using different definitions: cross-sectional (anthropometry less than 10th...
This prospective single-center study was designed to assess the clinical utility of FilmArray® blood culture identification (BCID) panel for improving diagnostic accuracy in neonatal sepsis. Results obtained using BCID were correlated with results all consecutive neonates suspicion early-onset (EOS) and late-onset sepsis (LOS) attended our service over a two-year period. A total 102 cultures from 92 included, 69 (67.5%) cases EOS 33 (32.3%) LOS. The performed negative bottles at median 10 h...
Introducción: El mejor alimento para los niños durante primeros seis meses de vida es la lactancia materna exclusiva (LME); se recomienda continuar con el amamantamiento junto otros alimentos que complementen alimentación hasta dos años o más, mientras madre e hijo lo deseen.Los objetivos este estudio fueron determinar tasa LME en recién nacidos a término (RNT) momento del alta hospitalaria y 15 días analizar factores influyen positivamente LME.Métodos: Estudio prospectivo reclutó una...
Background:The best nourishment for infants during the first six months of life is exclusive breastfeeding.It recommended along with other food to complement diet until child two years old, as long mother and are willing continue it.The objectives this study were determine breastfeeding rate in full-term newborns at hospital discharge 15 days later analyze factors that positively affect breastfeeding.Methods: A prospective was conducted which a sample postpartum women recruited...
The prevalence of postnatal growth faltering (PGF) in preterm infants with very low birth weight (VLBW) (<1500 g) is a universal problem. Growth improvement expected as neonatal care optimized. Objectives: To determine if there has been decrease the PGF and an height at 2 years appropriate for gestational age VLBW children last two decades. Methods: Clinical descriptive retrospective analysis somatometry two-year corrected infants. Small were excluded. Two cohorts (2002–2006, n = 112;...
One of the most common food allergies in pediatric population is allergy to cow's milk protein (CMPA). Treatment consists avoiding proteins lactating mothers and/or using therapeutic formulas based on hydrolysates or vegetable formulas. In infants with CMPA at diagnosis, a different gut microbial profile has been found compared healthy children, reduction beneficial bacteria. The aim this study was evaluate changes microbiota and its metabolites, dietary patterns anthropometric variables...
The gut microbiota is a key and primary stimulus for the development of host’s immune system. early establishment affected by several perinatal factors but little known about their influence on shaping normal and, consequently, programming future health. analysis different compounds well-documented in serum samples; however, presence faecal samples has not been studied, this information could be valuable life. In context, authors study aimed to both describe immunological profile cohort...