A5061919605- Plasma Diagnostics and Applications
- Cancer Genomics and Diagnostics
- Electrohydrodynamics and Fluid Dynamics
- Optical Coatings and Gratings
- Laser Design and Applications
- Genomics and Phylogenetic Studies
- Plasma Applications and Diagnostics
- Diamond and Carbon-based Materials Research
- Spectroscopy and Laser Applications
- Atomic and Subatomic Physics Research
- Molecular Biology Techniques and Applications
- Amphibian and Reptile Biology
- Chronic Myeloid Leukemia Treatments
- Atomic and Molecular Physics
- Quantum optics and atomic interactions
- Theatre and Performance Studies
- Wildlife-Road Interactions and Conservation
- Advanced Photocatalysis Techniques
- Sexual function and dysfunction studies
- Behavioral and Psychological Studies
- AI in cancer detection
- Animal and Plant Science Education
- Immunodeficiency and Autoimmune Disorders
- Photonic Crystals and Applications
- Nanofabrication and Lithography Techniques
Center for Drug Evaluation and Research
2021-2022
United States Food and Drug Administration
2021-2022
Mayo Clinic
2009
University of Alberta
2000-2004
Rutgers, The State University of New Jersey
1989-1996
Immunomedics (United States)
1995
University of Auckland
1977
Abstract Background The cancer genome is commonly altered with thousands of structural rearrangements including insertions, deletions, translocation, inversions, duplications, and copy number variations. Thus, variant (SV) characterization plays a paramount role in target identification, oncology diagnostics, personalized medicine. As part the SEQC2 Consortium effort, present study established evaluated consensus SV call set using breast reference cell line matched normal control derived...
The effects of frequency variation in a high-frequency (13.6-54.4 MHz), low-pressure (250 mTorr), capacitively coupled argon discharge have been investigated. Spatially resolved optical emission and RF voltage current measurements are reported. Results fluid model simulations also presented to aid the interpretation experiments. Scaling plasma parameters is studied under three conditions: constant frequency, applied current. scaling laws derived here suggest ways optimize very reactor for...
Accurate detection of somatic mutations is challenging but critical in understanding cancer formation, progression, and treatment. We recently proposed NeuSomatic, the first deep convolutional neural network-based mutation approach, demonstrated performance advantages on silico data.
ABSTRACT Six male and 6 female volunteers formed three groups of 4 subjects in a study on the efficacy different forms visual feedback control heart rate (HR). One group received proportional from meter plus binary success signal, one only feedback, signal. Subjects acquisition sessions extinction sessions. For HR increase, receiving showed mean over last 2 +10 bpm, whereas +4 bpm. decrease, both ‐4 negligible control. During there was no immediate reduction hi either increase or decrease...
Abstract Background The use of a personalized haplotype-specific genome assembly, rather than an unrelated, mosaic like GRCh38, as reference for detecting the full spectrum somatic events from cancers has long been advocated but never explored in tumor-normal paired samples. Here, we provide first demonstrated de novo assembled cancer mutation detection and quantifying effects genomes on accuracy detection. Results We generate assemblies genomes, both nuclear mitochondrial, derived same...
A two-dimensional fluid model is used to study the characteristics of a capacitively coupled discharge system at drive frequencies 13.56–100 MHz. Results are presented for large reactor that can accommodate 300 mm wafers. The plasma density and ion flux scale approximately as square frequency constant applied voltage which agrees well with measurements. rf current, ionization rate, sheath thickness also favorably frequency. simulations reveal uniform across electrode except near edge.
Laser optogalvanic (LOG) signals at 667.7, 751.5, and 696.5 nm from the 3 P1 P2 levels of Ar were studied a pressure 250 mTorr in rf glow discharge. Signals with unexpected signs time dependences found. The results are interpreted as being due to radiative trapping effects collisional mixing between resonance metastable levels. An average electron energy 2.1 eV is derived modeling data.
Electron-impact excitation rates in a capacitively coupled 13.6-MHz rf argon discharge were derived from optical emission measurements with high time and space resolution. A propagating wave form is shown to exist at gas pressures as 1.0 Torr. The observed features---including temporal broadening of the form---are agreement recent simulation results, can explain apparent transitions electron energy distributions previously reported.
A simple method for estimating the collection efficiency of a nearly ideal optical system is described. Calculation spatial response functions analysis and absolute calibration emission data emphasized. The geometric algorithm presented several orders magnitude faster than algorithms based on ray tracing. applied to case radially uniform cylindrical source between parallel plates results are in excellent agreement with tracing calculations.
The 3${\mathrm{}}^{3}$P--5${\mathrm{}}^{3}$S transition in atomic oxygen at 725.4 nm has been studied a weak discharge using the optogalvanic effect with cw tunable dye laser. appears as superposition of least two components different centroids and widths. anomalous line shape is probably due to long-range interaction $^{3}$P $^{4}$${\mathit{S}}_{0}$ ions.
A new technique based on the optogalvanic effect has been developed for measurement of stable isotope ratios in carbon dioxide exhaled breath. Data obtained before and after ingestion harmless labeled compounds, metabolized to dioxide, can be used sensitive noninvasive diagnostics various disease conditions. The uses specificity laser resonance spectroscopy achieves sensitivity accuracy typical sophisticated ratio mass spectrometers. Using fixed frequency lasers,...