A5048451267- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Brain Tumor Detection and Classification
- Cardiovascular Health and Disease Prevention
- Motor Control and Adaptation
- Neurological Disease Mechanisms and Treatments
- Medical Image Segmentation Techniques
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Consumer Perception and Purchasing Behavior
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Child Nutrition and Water Access
- Cardiovascular Health and Risk Factors
- Skin Protection and Aging
- Intracranial Aneurysms: Treatment and Complications
- Medical Imaging and Analysis
- Optical Imaging and Spectroscopy Techniques
- Neonatal and fetal brain pathology
- Memory and Neural Mechanisms
- Traumatic Brain Injury Research
Université de Sherbrooke
2024-2025
Concordia University
2018-2024
Missouri University of Science and Technology
2013
Elevated iron deposition in the brain has been observed older adult humans and persons with Alzheimer's disease (AD), associated lower cognitive performance. We investigated impact of deposition, its topographical distribution across hippocampal subfields segments (anterior, posterior) measured along longitudinal axis, on episodic memory a sample cognitively unimpaired adults at elevated familial risk for AD ( N = 172, 120 females, 52 males; mean age 68.8 ± 5.4 years). MRI-based quantitative...
Chronic low back pain (CLBP) is the leading cause of disability worldwide. Structural abnormalities in lumbar region rarely account for symptoms observed. In contrast, brain plays a central role chronic pain, with several studies suggesting that may result from persistence memories and/or inability to extinguish these following an initial inciting injury. Previous research has reported reduction grey matter density (GMD) CLBP patients, as measured by magnetic resonance imaging (MRI)....
Resting-state (rs) functional magnetic resonance imaging (fMRI) is used to detect low-frequency fluctuations in the blood oxygen-level dependent (BOLD) signal across brain regions. Correlations between temporal BOLD are commonly infer connectivity. However, because based on dilution of deoxyhemoglobin, it sensitive veins all sizes, and its amplitude biased by draining veins. These biases affect local location amplitude, may also influence BOLD-derived connectivity measures, but magnitude...
The Circle of Willis (CW), visualized via Magnetic Resonance Angiography (MRA), is crucial for assessing cerebral circulation. Accurate artery identification essential not only detecting stenosis and pathological changes but also understanding vascular adaptations in healthy aging. Manual CW assessment time-consuming, necessitating automated alternatives. This study evaluates intracranial diameter estimations from the Express IntraCranial Arteries Breakdown (eICAB) toolbox against manual...
In motor learning, sequence specificity, i.e. the learning of specific sequential associations, has predominantly been studied using task-based fMRI paradigms. However, offline changes in resting state functional connectivity after sequence-specific are less well understood. Previous research established that plastic following can be divided into stages including fast slow and retention. A description how (MSL) develops across these is missing. This study aimed to identify alterations...
Abstract The vascular organization of the human brain can determine neurological and neurophysiological functions, yet thus far it has not been comprehensively mapped. Aging diseases such as dementia are known to be associated with changes vasculature normative data could help detect these in neuroimaging studies. Furthermore, given well-known impact venous vessels on blood oxygen level dependent (BOLD) signal, information about common location veins biases existing datasets. In this work, a...
Quantitative susceptibility mapping (QSM) was used to evaluate hippocampal iron in a cohort of healthy older individuals at elevated risk for Alzheimer’s disease (AD), and related pattern separation completion memory performance. Our results demonstrated that brain content the hippocampus is strongly associated with lower performance on behavioral tests specific function, ie scores higher scores. findings suggest deposition may be pathological mechanism resulting poorer mnemonic...
Here we investigated the effect of coronary artery disease (CAD) on brain oxygen extraction fraction (OEF) using quantitative susceptibility mapping (QSM). Our results, in a pilot dataset, show that OEF was significantly higher CAD patients than healthy controls caudate nucleus. This may be result declining cerebrovascular health this region. However, since nucleus is iron-rich, difference also interpreted as iron deposition has known neuroinflammatory effect. Future work will investigate...
Alzheimer’s Disease (AD) is the most common form of dementia and displays a long preclinical phase. The use non-steroidal anti-inflammatory drugs (NSAIDs) in this phase has protective effect decreases risk developing AD cross-sectionally. However, effects NSAIDs therapy long-term on cerebral hemodynamics early unclear. This first study to assess whether longitudinal (i.e., naproxen) an impact blood flow, associated with change cognition and/or cerebrospinal fluid markers.
Abstract Disclosure: C. Marchildon: None. M. Arguin: Doyon: S. Cote: A. Michaud: J. Huck: V. Gingras: P. Perron: Hivert: L. Bouchard: K. Whittingstall: Objective: Several studies have linked maternal hyperglycaemia to diabetes-prone phenotype in the offspring, yet mechanisms underlying these associations remain unclear. In adults, hypothalamus is known play a crucial role progression of obesity and diabetes. utero exposure may thus selectively target developing hypothalamus. To test this...
Motivation: There is a lack of knowledge about the physiological underpinnings effects coronary artery disease (CAD) on human brain health. Goal(s): Here we investigated effect CAD oxygen extraction fraction (OEF) Approach: Using quantitative susceptibility mapping (QSM) and its relation to cognitive performance cardiorespiratory fitness. Results: The results sex-disaggregated analysis in preliminary dataset show that male patients have significantly higher OEF whole gray matter, frontal,...
Motivation: There is limited understanding regarding the physiological mechanisms underlying impact of coronary artery disease (CAD) on brain health. Goal(s): In this study, we sought to explore influence CAD vascular and metabolic biomarkers. Approach: Specifically examining Cerebrovascular Reactivity (CVR), Cerebral Blood Flow (CBF), Oxygen Extraction Fraction (OEF) in brain, how these factors relate cognitive performance. Results: Our initial findings, based a preliminary dataset,...
Abstract In motor learning, sequence-specificity, i.e. the learning of specific sequential associations, has predominantly been studied using task-based fMRI paradigms. However, offline changes in resting state functional connectivity after sequence-specific are less well understood. Previous research established that plastic following can be divided into stages including fast slow and retention. A description how sequence (MSL) develops across these is missing. This study aimed to identify...
Efficient neural transmission is crucial for optimal brain function, yet the plastic potential of white matter (WM) has long been overlooked. Growing evidence now shows that modifications to axons and myelin occur not only as a result long-term learning, but also after short training periods. Motor sequence learning (MSL), common paradigm used study neuroplasticity, occurs in overlapping stages different circuits are involved each stage. However, most studies investigating short-term WM...
It has been suggested that the absence of residual protection against recontamination is a potential weakness ceramic pot filters (CPFs). As result, and CPF manufacturers' recommendations, users may routinely apply bleach to CPFs as way prevent recontamination. Concerns regarding repercussions on CPFs' ability disinfect water and/or their lifespan due an interaction between chlorine silver, well health risks associated with poisoning chlorination disinfection by-products (DBPs) exist. This...