A5007258263- Tuberculosis Research and Epidemiology
- HIV/AIDS Research and Interventions
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- HIV Research and Treatment
- HIV, TB, and STIs Epidemiology
- Sex work and related issues
- HIV/AIDS drug development and treatment
- Genomics and Rare Diseases
- HIV-related health complications and treatments
- Genital Health and Disease
- vaccines and immunoinformatics approaches
Botswana Harvard AIDS Institute Partnership
2015-2019
University of KwaZulu-Natal
2018-2019
Kilimanjaro Christian Medical Centre
2015
Brigham and Women's Hospital
2013
Background Molecular typing of Mycobacterium tuberculosis (M.tb) isolates can inform Tuberculosis (TB) control programs on the relative proportion transmission driving TB epidemic. There is limited data M. tb genotypes that are circulating in Botswana. The aim this study was to generate baseline genetic diversity M.tb country. Methods A total 461 received at Botswana National Reference Laboratory between March 2012 and October 2013 were included study. Drug susceptibility testing conducted...
Background There is a high burden of tuberculosis (TB) in HIV antiretroviral programmes Africa. However, few studies have looked at predictors incident TB while on Truvada-based combination therapy (cART) regimens. Methods We estimated incidence among individuals enrolled into an observational cohort evaluating the efficacy and tolerability cART Gaborone, Botswana between 2008 2011. used Cox proportional hazards regressions to determine TB. Results Of 300 participants enrolled, 45 (15%) had...
The emergence and transmission of multidrug resistant (MDR) extensively drug (XDR) Mycobacterium tuberculosis (M.tb) strains is a threat to global (TB) control. early detection resistance critical for patient management. aim this study was determine the proportion isolates with additional second-line among rifampicin isoniazid MDR-TB isolates. A total 66 M.tb received at National Tuberculosis Reference Laboratory between March 2012 October 2013 isoniazid, or both were analyzed in study....
HIV infects cells of the immune system causing activation and proliferation cells, leading to alteration production activity a number cytokines. These changes in cytokine levels can affect function, have potential directly impact course disease. We characterized plasma concentration profiles HIV-1 subtype C chronically infected, antiretroviral therapy (ART)-naive participants establish their influence on disease progression viremia. Plasma interleukin (IL)-1α, IL-7, IL-12p40, granulocyte...
Risk of developing drug resistance after stopping antiretroviral regimens to prevent mother-to-child HIV-1 transmission is unknown. The Mma Bana Study randomized treatment-naive pregnant women with CD4 ≥200 cells per cubic millimeter receive either abacavir/zidovudine/lamivudine [triple nucleoside reverse transcriptase inhibitor (NRTI) arm] or lopinavir/ritonavir/zidovudine/lamivudine [protease (PI) arm]. Drugs were discontinued 6 months breastfeeding. One month discontinuation, 29 NRTI arm...
Objective: Tuberculosis (TB) remains one of the leading causes mortality and morbidity among people living with HIV. We sought to estimate incidence TB in a national database HIV-infected patients receiving antiretroviral therapy (ART) Botswana. Design: A retrospective analysis adult (≥18years) who initiated ART between 2011 2015 Botswana program. Methods: Multivariable using Cox regression included sex, age, viral load CD4+ T-cell counts. Results: Of 45 729 patients, median follow-up 1.7...