A5036289347- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Vaccine Coverage and Hesitancy
- HIV/AIDS Research and Interventions
- Global Health and Surgery
- Diagnosis and treatment of tuberculosis
- Genomics and Rare Diseases
- HIV Research and Treatment
Botswana Harvard AIDS Institute Partnership
2018-2025
South African Medical Research Council
2025
Stellenbosch University
2025
University of Botswana
2018-2020
<ns3:p>Emerging highly transmissible viral infections such as SARS-CoV-2 pose a significant global threat to human health and the economy. Since its first appearance in December 2019 city of Wuhan, Hubei province, China, infection has quickly spread across globe, with case reported on African continent, Egypt February 14<ns3:sup>th</ns3:sup>, 2020. Although number COVID-19 increased exponentially since beginning pandemic, new deaths recorded countries have been relatively modest, suggesting...
<ns3:p>Emerging highly transmissible viral infections such as SARS-CoV-2 pose a significant global threat to human health and the economy. Since its first appearance in December 2019 city of Wuhan, Hubei province, China, infection has quickly spread across globe, with case reported on African continent, Egypt February 14<ns3:sup>th</ns3:sup>, 2020. Although number COVID-19 increased exponentially since beginning pandemic, new deaths recorded countries have been relatively modest, suggesting...
Emerging highly transmissible viral infections such as SARS-CoV-2 pose a significant global threat to human health and the economy. Since its first appearance in December 2019 city of Wuhan, Hubei province, China, infection has quickly spread across globe, with case reported on African continent, Egypt February 14 th, 2020. Although number COVID-19 increased exponentially since beginning pandemic, new deaths recorded countries have been relatively modest, suggesting slower transmission...
Background The emergence of drug-resistant Mycobacterium tuberculosis ( M. tb ) strains remains a threat to (TB) prevention and care. Understanding the drug resistance profiles circulating is crucial for effective TB control. This study aimed describe genetic diversity rifampicin-resistant in Botswana using whole genome sequencing (WGS). Methods included 202 stored isolates from people diagnosed with (RR-TB) between January 2016 June 2023. Genomic DNA was extracted cetyltrimethylammonium...
Background Molecular typing of Mycobacterium tuberculosis (M.tb) isolates can inform Tuberculosis (TB) control programs on the relative proportion transmission driving TB epidemic. There is limited data M. tb genotypes that are circulating in Botswana. The aim this study was to generate baseline genetic diversity M.tb country. Methods A total 461 received at Botswana National Reference Laboratory between March 2012 and October 2013 were included study. Drug susceptibility testing conducted...
Background There is a high burden of tuberculosis (TB) in HIV antiretroviral programmes Africa. However, few studies have looked at predictors incident TB while on Truvada-based combination therapy (cART) regimens. Methods We estimated incidence among individuals enrolled into an observational cohort evaluating the efficacy and tolerability cART Gaborone, Botswana between 2008 2011. used Cox proportional hazards regressions to determine TB. Results Of 300 participants enrolled, 45 (15%) had...
The performance of host blood-based biomarkers for tuberculosis (TB) in HIV-infected patients on antiretroviral therapy (ART) has not been fully assessed. We evaluated the immune phenotype and functionality antigen-specific T-cell responses HIV positive (+) participants with TB (n = 12) compared to negative (-) either 9) or latent infection (LTBI) 9). show that cytokine profile Mtb-specific CD4+ T-cells TB, regardless status, was predominantly single IFN-γ dual IFN-γ/ TNFα. Whilst...
The emergence and transmission of multidrug resistant (MDR) extensively drug (XDR) Mycobacterium tuberculosis (M.tb) strains is a threat to global (TB) control. early detection resistance critical for patient management. aim this study was determine the proportion isolates with additional second-line among rifampicin isoniazid MDR-TB isolates. A total 66 M.tb received at National Tuberculosis Reference Laboratory between March 2012 October 2013 isoniazid, or both were analyzed in study....
Objective: Tuberculosis (TB) remains one of the leading causes mortality and morbidity among people living with HIV. We sought to estimate incidence TB in a national database HIV-infected patients receiving antiretroviral therapy (ART) Botswana. Design: A retrospective analysis adult (≥18years) who initiated ART between 2011 2015 Botswana program. Methods: Multivariable using Cox regression included sex, age, viral load CD4+ T-cell counts. Results: Of 45 729 patients, median follow-up 1.7...
We report the final analysis of single-arm open-label study evaluating safety and COVID-19 incidence after AZD1222 vaccination in Botswana conducted between September 2021 August 2022.
Background The emergence and transmission of multidrug-resistant (MDR) extensively drug-resistant (XDR) Mycobacterium tuberculosis (Mtb) strains is a serious threat to control in Botswana. Early detection isolates critical ensure optimal treatment thereby improve outcomes. objective this study was determine the extent second-line drug resistance among Mtb-isolates from Methods A total 60 Mtb received at Botswana National Tuberculosis Reference Laboratory between 2012 2013 were analysed. DNA...