A5052004061- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Sex work and related issues
- HIV Research and Treatment
- Vaccine Coverage and Hesitancy
- Adolescent Sexual and Reproductive Health
- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Reproductive tract infections research
- Biosimilars and Bioanalytical Methods
- HIV/AIDS Impact and Responses
- Ethics in Clinical Research
- Syphilis Diagnosis and Treatment
Botswana Harvard AIDS Institute Partnership
2017-2023
Harvard University
2019-2021
Background: HIV Vaccine Trials Network 703/HIV Prevention 081 is a phase 2b randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of passively infused monoclonal antibody VRC01 in preventing acquisition heterosexual women between ages 18 50 years at risk HIV. Participants were enrolled 20 sites Botswana, Kenya, Malawi, Mozambique, South Africa, Tanzania, Zimbabwe. It one 2 Antibody Mediated trials, with 704/HIV 085, evaluating for prevention. Methods: Intense...
Background HIV prevalence among female sex workers (FSW) in sub-Saharan Africa is much higher than the general population. self-testing (HIVST) may be useful for increasing testing rates FSW. Methods We conducted semi-structured in-depth interviews FSW, nurses and lay counsellors providing services to FSWs Botswana. aimed gain understanding of perceived acceptability, anticipated barriers, preferred approaches HIVST Interviews were audio-recorded, transcribed translated. Transcripts reviewed...
Introduction: The HIV Prevention Trials Network (HPTN) 052 trial demonstrated that early antiretroviral therapy (ART) prevented 93% of transmission events in serodiscordant couples. Some linked infections were observed shortly after ART initiation or virologic failure.Objective: To evaluate factors associated with time to viral suppression and failure participants who initiated HPTN 052.Methods: 1566 had a load (VL) > 400 copies/mL at enrollment included the analyses. This 832 arm (CD4...
Background: Little is known about the combined impact of HIV/syphilis coinfection on birth outcomes. Methods: Antenatal HIV and syphilis test results, obstetric history, infant outcomes were collected from records in maternity wards Botswana between 2008 2011 (5 sites) 2014 2016 (8 sites). We used logistic regression to compare adverse by status. Outcomes included stillbirth, preterm delivery, low weight, in-hospital neonatal death. Results: Of 76,466 women, 75,770 (99.1%) had 20,520 (27.1%)...
Background Oral HIV self-testing (HIVST) may be useful for increasing testing in persons at elevated risk of acquiring HIV. Methods We conducted a pilot study to evaluate the feasibility (defined by uptake) HIVST among FSW Gaborone, Botswana. age 18 years and above were recruited through non-governmental organization serving FSW. with unknown or negative status screening performed clinic following brief training. HIV-negative each given two test kits take home: one kit perform unassisted...
Understanding the role of opiate dependency treatment in risky sexual behavior could help optimize interventions for people who inject drugs (PWID).We evaluated whether long-term medication-assisted (LT-MAT) with buprenorphine/naloxone influenced among HIV-uninfected PWID and identified predictors behavior.We used data from HPTN 058, a randomized controlled trial LT-MAT vs. short-term China Thailand. We associations between group self-reported behaviors within past month: condomless sex...
We report the final analysis of single-arm open-label study evaluating safety and COVID-19 incidence after AZD1222 vaccination in Botswana conducted between September 2021 August 2022.
Abstract Background The Antibody-mediated Prevention (AMP) trials (HVTN 704/HPTN 085 and HVTN 703/HPTN 081) are the first efficacy to evaluate whether VRC01, a broadly neutralizing antibody (bnAb) that targets CD4 binding site of HIV envelope, prevents acquisition in uninfected individuals. In these ongoing trials, 10 intravenous (IV) infusions VRC01 given every 8 weeks over period 2 years. We report on interim operational feasibility, enrollment safety. Methods Participant recruitment was...
Sexually transmitted infections (STIs) remain a public health concern because of their interaction(s) with HIV. In the HPTN 052 study, STIs were evaluated in both HIV-positive index cases and HIV-negative partners at enrollment yearly follow-up visits. Our definition for STI was based on any infection Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis, or Trichomonas vaginalis. We used log-binomial regression models to identify factors associated prevalent STIs. Generalized estimating...