A5009986416- Dialysis and Renal Disease Management
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Inflammasome and immune disorders
- Potassium and Related Disorders
- Heart Failure Treatment and Management
- Ion Transport and Channel Regulation
- Coenzyme Q10 studies and effects
- Biochemical Acid Research Studies
- Sleep and Work-Related Fatigue
- Pediatric health and respiratory diseases
- Tryptophan and brain disorders
- Workplace Health and Well-being
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sleep and related disorders
- Magnesium in Health and Disease
- Muscle metabolism and nutrition
- Clinical Nutrition and Gastroenterology
- Neuroinflammation and Neurodegeneration Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Vitamin D Research Studies
- Immune cells in cancer
- Stress Responses and Cortisol
- Nitric Oxide and Endothelin Effects
University of Thessaly
2008-2021
Abstract Background: Most cancer cells rely on aerobic glycolysis. Dichloroacetate (DCA) inhibits glycolysis and is a promising relatively nontoxic anticancer compound. However, rapidly proliferating effector T-cells also glycolysis, whereas regulatory (Treg) do not. The effect of DCA glucose metabolism Treg differentiation was evaluated in alloreactive lymphocytes. Methods: Peripheral blood mononuclear from healthy volunteers were used two-way mixed lymphocyte reaction. Lymphocyte...
Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity. It is known that IDO induces T-cell differentiation to regulatory T-cells (Treg) through tryptophan depletion and/or kynurenine pathway products. CD4+ effector require distinct metabolic programs in order support their function as compared Treg cells. Furthermore, glucose metabolism also affect B-cell survival and function. The effect of on lymphocytes was evaluated by using its inhibitor 1-methyl-DL-tryptophan (1-MT).Ten...
Abstract Mesothelium is an important part of the peritoneal barrier for water and ion transport, essential effective dialysis ( PD ). Peritoneal fibrosis has been associated with treatment failure. Endothelin‐1 ET ‐1) a potent vasoactive peptide, involved in pathologic fibrotic processes. Its action mediated mainly by endothelin type A ) B receptors. The aim this study was to investigate, U ssing chamber experiments, effect ‐1 on transmesothelial electrical resistance R TM isolated visceral...
Chronic kidney disease (CKD) is accompanied by a disturbed redox homeostasis, especially in end-stage patients, which associated with pathological complications such as anemia, atherosclerosis, and muscle atrophy. However, limited evidence exists about disturbances before the end stage of CKD. Moreover, available literature has not yet provided clear associations between circulating tissue-specific (muscle) oxidative stress levels. The aim study was to evaluate commonly used status indices...