A5072984368- Autism Spectrum Disorder Research
- Family and Disability Support Research
- Infant Development and Preterm Care
- Genetics and Neurodevelopmental Disorders
- Child Nutrition and Feeding Issues
- Child Development and Digital Technology
- Healthcare Systems and Technology
- Cardiac, Anesthesia and Surgical Outcomes
- Family and Patient Care in Intensive Care Units
- Congenital heart defects research
- COVID-19 and Mental Health
- Child and Adolescent Health
- Sleep and related disorders
- Child and Adolescent Psychosocial and Emotional Development
- Childhood Cancer Survivors' Quality of Life
- Resilience and Mental Health
- Early Childhood Education and Development
- Dental Health and Care Utilization
- Impact of Technology on Adolescents
- Ethics and Legal Issues in Pediatric Healthcare
- Sleep and Wakefulness Research
- Primary Care and Health Outcomes
- Telemedicine and Telehealth Implementation
- Vaccine Coverage and Hesitancy
- Sleep and Work-Related Fatigue
National University of Singapore
2009-2025
National University Health System
2016-2025
National University Hospital
2011-2024
Khoo Teck Puat Hospital
2020-2024
Clinical Nutrition Research Centre
2024
University of California, Davis
2022-2023
NeuroDevelopment Center
2023
University of California Davis Medical Center
2023
University Health System
2012
While behavioral interventions remain the mainstay of treatment autism spectrum disorder (ASD), several potential targeted treatments addressing underlying neurophysiology ASD have emerged in last few years. These are promising for to, future, become part core symptoms ASD. Although it is likely that development future will be influenced by heterogeneity etiology, associated genetic mechanisms influencing to first targets and even gene therapy In this article, we provide a review current...
The concepts of health, illness, and disability as well the perceptions autism quality life (QoL) vary greatly across cultures time. This study sought to explore interplay culture on QoL impact parents caring for autistic children.We used a transcultural dataset from seven countries (Australia, Hungary, Malaysia, Romania, Singapore, Spain, United Kingdom) with participating parents/carers reporting Quality Life in Autism (QoLA) questionnaire. QoLA questionnaire is validated measure children,...
We investigated the molecular and clinical profile of five boys carrying fragile X messenger ribonucleoprotein 1 (FMR1) mutation who suffered from effects prenatal alcohol exposure. Fragile syndrome (FXS) testing was performed using PCR Southern Blot analysis, protein (FMRP) expression levels were measured by Western blot analysis. Clinical evaluation included cognitive functions, adaptive skills, autism phenotype, severity behavior measures. Fetal Alcohol Spectrum Disorder (FASD) also...
Abstract Purpose Autism is more common among children born preterm than term. This study determined the prevalence of positive autism screening 18-30 month old preterm-born and evaluated sociodemographic, clinical, neurodevelopmental factors associated with screens. Methods Secondary analyses Stanford data from California Perinatal Quality Care Collaborative. Infants < 32 weeks gestation between 2016-2020, who attended High-Risk Infant Follow-Up at months, were classified into two groups...
The coronavirus disease 2019 (COVID-19) pandemic has disrupted societies globally.As of 11 May 2020, 53 children have been infected with COVID-19 in Singapore (Ministry Health, Singapore, unpublished data).Children generally mild disease, 1 although there is emerging literature on paediatric multisystem inflammatory syndrome temporally associated COVID-19.Less well reported the impact daily lives and psychology children.This article highlights implications an especially vulnerable population...
Carriers of a premutation allele (PM) in the FMR1 gene are at risk developing number Fragile X asssociated disorders (FXPAC), including X-associated Tremor/Ataxia Syndrome (FXTAS), Primary Ovarian Insufficiency (FXPOI), and neuropsychiatric (FXAND). We have recently reported somatic CGG expansion female PM; however, its clinical significance remains unclear. The aim this study was to examine potential association between instability PM associated disorders. Participants comprised 424...
ABSTRACT: Objective: Screen time in early childhood has been associated with children's prosocial and behavioral skills; however, the directionality of this relationship is unclear. We aimed to determine direction between screen time, social skills, nonsocial traits young children. Methods: This was a population-based, prospective cohort study data across 5 points. examined reciprocal relationships caregiver-reported at 12, 18, 24, 36, 54 months behaviors collected using Infant-Toddler...
This study aimed to determine patterns of screen viewing time (SVT) in preschool children with developmental, behavioural or emotional (DBE) issues, and identify its relationship social-emotional development.
Although infant media exposure has received attention for its implications on child development, upstream risk factors contributing to have rarely been explored. The study aim was examine the relationship between maternal factors, television (TV) viewing, and later cognition. We used a prospective population-based birth cohort study, Growing Up in Singapore Towards healthy Outcomes (GUSTO), with 1247 pregnant mothers recruited their first trimester. explored of TV at 12 months composite IQ...
We evaluated factors affecting psychological ill-effects and resilience of caregivers children with developmental disabilities during the coronavirus pandemic. Depression, Anxiety, Stress Scales (DASS-21) Connor-Davidson Resilience Scale 25-item were administered. Logistic regression was used to identify associated resilience. DASS-21 depression, anxiety stress scores high; these difficulties infection control measures, autism diagnosis, need for early intervention services. For ASD, our...
Abstract Background Children with autism spectrum disorders (ASD) face challenges in home oral care, accessing a dentist and accepting dental treatment. Aim To determine the barriers to care for autistic children Singapore through experiences opinions of their parents. Design A qualitative exploratory approach comprising semistructured interviews focus group discussion was used. Audio recordings were transcribed coded into themes using NVivo 12 software. Results Participants 23 parents aged...
Introduction: Sleep problems are common in all ages, but may be particularly acute urban Singapore. This study aims to describe the sleep behaviour of, and identify any in, preschool children. Materials Methods: was a cross-sectional questionnaire survey of 372 children attending local childcare centers. The based on Children’s Habits Questionnaire (CSHQ), validated parent-report screening that contains 54 items identifying behaviours Results: A total (40.0%) participated. mean age 4.1 (SD...
Background: The fragile X premutation carrier state (PM) (55–200 CGG repeats in the messenger ribonucleoprotein 1, FMR1 gene) is associated with several conditions, including X-associated primary ovarian insufficiency (FXPOI) and tremor ataxia (FXTAS), current literature largely primarily investigating older PM individuals. aim of this study was to identify prevalence neurodevelopmental disorders (FXAND) a sample young Methods: This retrospective conducted through medical record review...
Subjective indicators of health like self-rated (SRH) have been shown to be a predictor mortality and morbidity. We determined the prevalence poor SRH in Singapore its association with various lifestyle socioeconomic factors disease states.Cross-sectional survey by interviewer-administered questionnaire participants aged 40 years above. was assessed from standard question categorised into poor, fair, good or excellent. Lifestyle factors, presence states were also assessed.Out 409...
ABSTRACT Aims and objective To explore the experiences support needs of parents children with recently diagnosed autism spectrum disorder (ASD) in Singapore. Background Raising a child ASD is challenging for parents, especially initial period following diagnosis. Limited studies have focused on parents’ perspectives. Design A qualitative descriptive design study. Methods Thirteen were recruited from developmental behavioural paediatric outpatient clinic tertiary hospital Singapore...
Aim Children with developmental disabilities are at risk of excessive screen time and more vulnerable to sleep problems. The aim this study was determine the extent use in children its relationship duration. Methods Consecutive aged 6–15 years diagnosed Diagnostic Statistical Manual Mental Disorders, Fourth or Fifth Edition (DSM‐IV DSM‐5) were recruited for from December 2014 April 2015. Of those recruited, 87.0% families gave consent provided questionnaire information on demographics...
BackgroundAs the coronavirus 2019 pandemic continues, healthcare services need to adapt continue providing optimal and safe for patients. We detail our adaptive framework as a large Developmental Behavioral Pediatrics service in tertiary academic institution Singapore.MethodsThe multidisciplinary team at unit implemented various adaptations workflow processes during this evolving continued clinical care tailored challenges specific patient population. Services were via teleconsultation mode...
The Coronavirus Disease 2019 pandemic by virtue of its sudden, unprecedented and widespread nature, has led to a multitude psychological effects on individuals across societies. This includes anxiety which important implications the daily functioning, physical mental health individuals. Children are vulnerable group population who can experience potentially lead long-lasting their for years come. It is thus that caregivers, including parents healthcare professionals be aware strategies help...