A5077656047- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Cardiovascular and exercise physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Mitochondrial Function and Pathology
- Cardiac Valve Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Liver Disease and Transplantation
- Congenital heart defects research
- Healthcare Regulation
- Obesity, Physical Activity, Diet
- Neonatal Respiratory Health Research
- Consumer Attitudes and Food Labeling
- Regulation of Appetite and Obesity
- Medicinal Plant Extracts Effects
- Biochemical effects in animals
- Orthopaedic implants and arthroplasty
- Health, Education, and Aging
Universidade Estadual Paulista (Unesp)
2018-2024
Inclusione Andicap Ticino
2021
In pathological cardiac hypertrophy, the heart is more dependent on glucose than fatty acids. This shift in energy metabolism occurs due to several factors, including oxygen deficit, which activates hypoxia-inducible factor-1α (HIF-1α), a critical molecule related metabolism. However, there are gaps regarding behavior of key proteins glycolytic pathway and HIF-1α during transition from hypertrophy failure (HF). study assesses hypothesis that an early change enhancement pathway, as well...
Obesity is considered an important risk factor for several disorders, such as diabetes mellitus, systemic arterial hypertension, dyslipidemia, and atherosclerosis, which are associated with inflammation oxidative stress a trigger factor. Passiflora edulis contains bioactive compounds, phenolics, carotenoids, vitamin C, polyamines in pulp, leaves, seeds, bark. Aim: To evaluate the effect of bark (BPe) on body composition, metabolic parameters genetically obese mice. Methods: Obese male db/db...
Obesity is a pandemic associated with high incidence of cardiovascular disease; however, the mechanisms are not fully elucidated. Proteomics may provide more in-depth understanding pathophysiological and contribute to identification potential therapeutic targets. Thus, our study evaluated myocardial protein expression in healthy obese rats, employing two proteomic approaches. Male Wistar rats were established groups (n = 13/group): control diet Western fed for 41 weeks. was determined by...
Abstract The effects of exercise training (ET) on the heart aortic stenosis (AS) rats are controversial and mechanisms involved in alterations induced by ET have been poorly clarified. In this study, we analyzed myocardial proteome to identify proteins modulated moderate‐intensity aerobic with chronic supravalvular AS. Wistar were divided into four groups: sedentary control (C‐Sed), exercised (C‐Ex), (AS‐Sed), AS (AS‐Ex). consisted five treadmill running sessions per week for 16 weeks....
We employed an early training exercise program, immediately after recovery from surgery, and before severe cardiac hypertrophy, to study the underlying mechanism involved with amelioration of dysfunction in aortic stenosis (AS) rats. As ET induces angiogenesis oxygen support, we aimed verify effect on myocardial lipid metabolism disturbance. Wistar rats were divided into Sham, trained Sham (ShamT), AS (AST). The consisted 5-week sessions treadmill running for 16 weeks. Statistical analysis...
Cardiac remodeling (CR) is a structural change of the heart due to chronic hemodynamic overload related changes in both myocyte and extracellular matrix (ECM). We investigated that imbalance collagen V promotes cardiomyocyte apoptosis contributes failure cell death. Aortic stenosis was induced surgically male Wistar rats were randomized 18 weeks (Sham w, n = 12; AoS 12) severe HF, groups. Functional echocardiogram, immunohistochemistry for Ki-67, TUNEL assay Immunofluorescence performed. Our...
Severe food restriction (FR) impairs cardiac performance, although the causative mechanisms remain elusive. Since proteins associated with calcium handling may contribute to dysfunction, this study aimed evaluate whether severe FR results in alterations expression and activity of Ca2+-handling that impaired myocardial performance. Male 60-day-old Wistar-Kyoto rats were fed a control or restricted diet (50% reduction consumed by group) for 90 days. Body weight, body fat pads, adiposity index,...
Obesity is recognized worldwide as a complex metabolic disorder that has reached epidemic proportions and often associated with high incidence of cardiovascular diseases. To study this pathology evaluate cardiac function, several models diet-induced obesity (DIO) have been developed. The Western diet (WD) one the most widely used models; however, variations in composition time period experimental protocol make comparisons challenging. Thus, aimed to effects two different types on remodeling...
Background/aims The beneficial effect of aerobic exercise training (ET) on cardiac remodeling caused by supravalvar aortic stenosis (AS) has been demonstrated in experimental studies; however, the mechanisms responsible for improving function are not entirely understood. We evaluated whether ET-generated cardioprotection pressure-overloaded rats is dependent cardiomyocyte proliferation, increased angiotensin-(1-7) (Ang-1-7) levels, and its receptor myocardium. Methods Eighteen weeks after...
Aerobic exercise training (AET) has been used to manage heart disease. AET may totally or partially restore the activity and/or expression of proteins that regulate calcium (Ca2+) handling, optimize intracellular Ca2+ flow, and attenuate cardiac functional impairment in failing hearts. However, literature presents conflicting data regarding effects on transit function rats with failure resulting from aortic stenosis (AoS). This study aimed evaluate impact handling due AoS. Wistar were...
Sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) and sarcolemmal Na+/Ca2+ exchanger (NCX1) structures are involved in heart cell Ca2+ homeostasis. Previous studies have shown discrepancies their function expression failure. The goal of this study was to evaluate hypertrophied muscle Ca2+-handling protein behavior under pressure overload. Twenty male Wistar rats were divided into two groups: Aortic stenosis (AoS), induced by a clip placed at the beginning aorta, Control (Sham). After 18 weeks,...
Background/aims Aortic stenosis-induced chronic pressure overload leads to cardiac dysfunction and congestive heart failure. The pathophysiological mechanisms of the myocardial impairment are multifactorial include maladaptive β-adrenergic signaling. Exercise training (ET) has been used as a non-pharmacological therapy for failure management. present study tested hypothesis that exercise attenuates diastolic through signaling preservation. Methods Wistar rats were submitted ascending aortic...
This study was designed to apply the vertebral heart scale system determine radiographic size in working Belgian Shepherd Malinois dogs. Right lateral thoracic radiographs from nineteen healthy dogs, weighting 24+/- 2.85 kg and ageing one 8 years were analyzed. The overall mean (VHS) calculated 9.58 +/-0.53 units, ranging 8.52 10.35v, with coefficient of variation 5.5%. No significant gender influence on values observed.
Aerobic exercise training (AET) has been used in the management of heart disease. AET may, totally or partially, restore activity and/or expression proteins that regulate calcium (Ca2+) handling, optimize intracellular Ca2+ flow, and attenuate cardiac functional impairment failing hearts. However, literature presents conflicting data regarding effects on transit function rats with failure resulting from aortic stenosis. The objective this study was to evaluate handling due Wistar were...
Introduction: Excessive intake of sugars, especially sucrose (a dimer glucose and fructose monomers) together physical inactivity, are highly correlated with the development cardiovascular disease. The diseases leading cause death globally responsible to imposing huge burdens on health care systems. Among disease we have those that affect heart. cardiac remodeling as a common physiopathology process. disturbance in calcium handling proteins well inflammation extensively accepted takes part...
We evaluated the influence of aerobic physical exercise (EX) on gene-encoding proteins associated with oxidative stress in diaphragm muscle rats aortic stenosis-induced heart failure (HF). Wistar male were divided into four groups: Control sedentary (C); (C-Ex); Sedentary stenosis (AS); Aortic (AS-Ex). Exercised trained 5 times a week for 10 weeks treadmill. Statistical analysis was performed by ANOVA or Kruskal-Wallis test. In final echocardiogram, animals subjected to demonstrated...
Maladaptive cardiac remodelling is characterized by diastolic and systolic dysfunction, culminating in heart failure. In this context, the dysfunctional scenario of calcium (Ca2+) handling has been poorly studied. An experimental model aortic stenosis extensively used to improve knowledge about key mechanisms pathologic remodelling.To understand process major components responsible for Ca2+ balance its influence on function failure induced stenosis.Male 21-day-old Wistar rats were...