A5084515555- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Child Nutrition and Water Access
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Prenatal Screening and Diagnostics
- Healthcare Systems and Reforms
- Global Maternal and Child Health
- Pregnancy and Medication Impact
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Neonatal Respiratory Health Research
- Chromosomal and Genetic Variations
- Gestational Diabetes Research and Management
- Global Health Care Issues
- Maternal and fetal healthcare
- Health Promotion and Cardiovascular Prevention
- Epigenetics and DNA Methylation
- Nuclear Structure and Function
- Community Health and Development
- Zebrafish Biomedical Research Applications
- Ectopic Pregnancy Diagnosis and Management
- Blood Pressure and Hypertension Studies
University of Pennsylvania
2018-2025
Hospital of the University of Pennsylvania
2024-2025
Johns Hopkins University
2024
Philadelphia University
2024
California University of Pennsylvania
2019-2020
Southern Illinois University Carbondale
2018
University of Hawaiʻi at Mānoa
2018
University of California, Davis
2018
Yale Cancer Center
2013
Yale University
2008-2013
Abstract Successful establishment of pregnancy requires adhesion an embryo to the endometrium and subsequent invasion into maternal tissue. Abnormalities in this critical process implantation placentation lead many complications. Here we present a microenigneered system model complex sequence orchestrated multicellular events that plays essential role early pregnancy. Our implantation-on-a-chip is capable reconstructing three-dimensional structural organization maternal-fetal interface...
Definitive hematopoietic stem and progenitor cells (HSPCs) arise from a small number of hemogenic endothelial (HECs) within the developing embryo. Understanding origin ontogeny HSPCs is considerable interest potential therapeutic value. It has been proposed that murine placenta contains HECs differentiate into HSPCs. However, during human gestation in aorta considerably earlier than when they can first be detected placenta, suggesting may primarily serve as niche. We found Runx1...
Introduction Prior to pregnancy, hormonal changes lead cellular adaptations in the endometrium allowing for embryo implantation. Critical successful pregnancy establishment, innate immune cells constitute a significant proportion of uterine prior arrival and throughout first trimester humans animal models. Abnormal cell function during implantation is believed play role multiple adverse outcomes. Current work has focused on present after limited vitro models exist explore unique functions...
How does an altered maternal hormonal environment, such as that seen during superovulation with gonadotropins in ART, impact human uterine immune cell distribution and function the window of implantation?
Abstract In vitro fertilization (IVF) is associated with DNA methylation abnormalities and a higher incidence of adverse pregnancy outcomes. However, which exposure(s), among the many IVF interventions, contributes to these outcomes remains unknown. Frozen embryo transfer (ET) increasingly utilized as an alternative fresh ET, but reports suggest pre-eclampsia large for gestational age infants. This study examines in human placentas using 850K Infinium MethylationEPIC BeadChip array obtained...
Preterm birth (PTB) affects approximately 1 in 10 pregnancies and contributes to 50% of neonatal mortality. However, despite decades research, little is understood about the etiology PTB, likely due multifactorial nature disease. In this study, we examined preterm term placentas, from unassisted conceptions those conceived using vitro fertilization (IVF). IVF increases risk PTB causes epigenetic change placenta fetus; therefore, utilized these patients as a unique population with potential...
ABSTRACT Inappropriate type I interferon (IFN) signaling during embryo implantation and placentation is linked to poor pregnancy outcomes. Here, we evaluated the consequence of elevated IFN exposure on using a biomimetic model human in an organ-on-a-chip device. We found that reduced extravillous trophoblast (EVT) invasion capacity. Analyzing single-cell transcriptomes, uncovered truncated endovascular EVT emergence implantation-on-a-chip device by stunting epithelial-to-mesenchymal...
Abstract Superovulation with gonadotropins alters the hormonal milieu during early embryo development and placentation, may be responsible for fetal placental changes observed after in vitro fertilization (IVF). We hypothesized that superovulation has differential effects depending on timing of exposure. To test our hypothesis, we isolated effect pre- peri-implantation mouse embryos. Blastocysts were obtained from either natural mating or following mating, transferred into naturally mated...
Abstract Disruption in homeostasis of IL-15 is linked to poor maternal and fetal outcomes during pregnancy. The only cells described respond at the early maternal–fetal interface have been NK cells. We now show a novel population macrophages, evident several organs but enriched uterus mice humans, expressing β-chain IL-15R complex (CD122) responding IL-15. CD122+ macrophages (CD122+Macs) are morphologic, phenotypic, transcriptomic that can derive from bone marrow monocytes. CD122+Macs...
Abstract Background In India, several state governments are implementing or considering home-based hypertension screening programs to improve population-wide diagnosis and blood pressure (BP) control rates. However, there is limited evidence on the effectiveness of in India. Methods Using six waves population-representative cohort data (N = 15,573), we estimate causal effect a intervention diagnosis, treatment, BP using novel application Regression Discontinuity Design. Findings We find that...
Abstract Scientific understanding of the relationship between environmental hazards and cognitive health at older ages in low- middle-income countries (LMICs) is poor. Using data from Longitudinal Aging Study India World Health Organization’s Survey on Global AGEing adult for four LMICs, we examine association direct local exposure to polluting cooking fuels with ages. We document negative influence both: poorer among household members who use residents neighborhoods where more common. find...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and resulting disease (COVID-19) causes placental dysfunction, which increases the risk of adverse pregnancy outcomes. While abnormal pathology from COVID-19 is common, direct placenta rare. This suggests that pathophysiology associated with maternal COVID-19, rather than infection, responsible for dysfunction alteration transcriptome. We hypothesized circulating extracellular vesicles (EVs), altered by during pregnancy,...
India rolled out ambitious program efforts for health and nutrition (H&N) in 2005–06, scaling up community H&N services through the National Rural Health Mission Integrated Child Development Services (ICDS). Evidence on combined reach impact of these programs closing equity gaps is limited. We aimed to assess how coverage interventions have changed between 2006 2016. used two rounds Family Survey data collected 2016 (n = 36,850 190,898 mother-child dyads with last child aged 0–5 y,...
Implementation research can support iterative program improvement, yet limited examples of such dynamic experiences exist. We conducted a multi-stage and multi-method process evaluation (PE) large-scale m-Health intervention in India that currently reaches 581,282 frontline workers (FLWs). The (Common Application Software (CAS)) includes smartphone application digitizes FLW service-tracking registers acts as job aid multiple dashboards for real-time monitoring. examined factors affecting the...