A5029541208- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Genetic Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Trypanosoma species research and implications
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Pesticide Exposure and Toxicity
- Research on Leishmaniasis Studies
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Cardiomyopathy and Myosin Studies
- Insect and Pesticide Research
- Electrochemical Analysis and Applications
- Atrial Fibrillation Management and Outcomes
- Artificial Intelligence in Healthcare and Education
- Coenzyme Q10 studies and effects
- Cardiac Arrest and Resuscitation
- Bone Tissue Engineering Materials
- Renin-Angiotensin System Studies
- Muscle Physiology and Disorders
- Graphene and Nanomaterials Applications
- Pesticide Residue Analysis and Safety
- Cardiac Ischemia and Reperfusion
- Calcium signaling and nucleotide metabolism
Faculdade de Ciências Médicas de Minas Gerais
2023-2024
Brazilian Synchrotron Light Laboratory
2023
Universidade Federal de Minas Gerais
2014-2022
Universidade Federal de São Paulo
2020-2022
Universidade Federal do ABC
2022
Western University
2021
ABSTRACT: Rats and mice are the most common species used in experimental cardiac electrophysiology studies. Electrocardiogram (ECG) recording shows paramount importance for monitoring arrhythmias function several disease models, including QT syndrome. However, lack of standardized reference values correction formula different animal lineages represent a challenge ECG interpretation. The aim this study is to provide an improved method recording, establishing range determine formulas with...
Chagas Disease (CD) is one of the leading causes heart failure and sudden death in Latin America. Treatments with antioxidants have provided promising alternatives to ameliorate CD. However, specific roles major reactive oxygen species (ROS) sources, including NADPH-oxidase 2 (NOX2), mitochondrial-derived ROS nitric oxide (NO) progression or resolution CD are yet be elucidated. We used C57BL/6 (WT) a gp91PHOX knockout mice (PHOX-/-), lacking functional NOX2, investigate effects ablation...
Huntington's disease (HD) is a neurodegenerative genetic disorder. Although described as brain pathology, there evidence suggesting that defects in other systems can contribute to progression. In line with this, cardiovascular are major cause of death HD. To date, relatively little known about the peripheral abnormalities associated disease. Here, we applied range assays evaluate cardiac electro-mechanical properties vivo, using previously characterized mouse model HD (BACHD), and vitro,...
Abstract Involuntary choreiform movements are clinical hallmark of Huntington's disease, an autosomal dominant neurodegenerative disorder caused by increased number CAG trinucleotide repeats in the huntingtin gene. start with impairment facial muscles and then affect trunk limbs muscles. disease symptoms changes cortex striatum neurons induced mutated protein. However, little is known about impact this abnormal protein spinal cord motoneurons that control movement. Therefore, study we...
The Renin-Angiotensin System (RAS) is expressed in the central nervous system and has important functions that go beyond blood pressure regulation. Clinical experimental studies have suggested alterations brain RAS contribute to development progression of neurodegenerative diseases. However, there limited information regarding involvement components Huntington's disease (HD). Herein, we used HD murine model, (BACHD), as well samples from patients with investigate role both classical...
Huntington's disease (HD) is a neurodegenerative caused by CAG repeat expansion in the gene encoding huntingtin protein (HTT). This leads to formation of mutant (mHTT) that expressed many body tissue cells. The mHTT interacts with several molecular pathways within different cell types, affecting regulation immune system It still very limited understanding changes peripheral tissues HD. Herein, we investigated levels inflammatory and regulatory cytokines organs (i.e. kidney, heart, liver...
What is the central question of this study? Recently, there have been many studies exploring biological effects angiotensin-(1-7), which has proved to cardioprotective actions. However, peptide on cardiac arrhythmias in vivo and details regarding its mechanism action are still undetermined. main finding importance? We investigated protective angiotensin-(1-7) vivo, were not properly explored terms cellular mechanisms. To verify we used different but complementary experimental approaches. Our...
This study aimed to investigate the chronic effects of caudal artery denervation on morphometric parameters tail vascular smooth muscle and physical exercise-induced thermoregulatory cardiovascular adjustments in rats. Male Wistar rats were subjected or sham procedure. Approximately 26-28 days after these procedures, their evaluated at rest during following a fatiguing treadmill run. At end experiments, euthanized, samples tails removed evaluate surrounding artery. Denervated showed...
It has been demonstrated that carbon nanotubes (CNTs) associated with sodium hyaluronate (HY-CNTs) accelerate bone repair in the tooth sockets of rats. Before clinical application HY-CNTs, it is important to assess their biocompatibility. Moreover, cardiac toxicity may be caused by translocation these particles blood stream. The aim this study was evaluate possible changes cardiovascular function male Wistar rats whose were treated either CNTs or HY-CNTs (100 μg/mL, 0.1 mL). Blood pressure...
Abstract The sympathetic nervous system is essential for maintenance of cardiac function via activation post-junctional adrenergic receptors. Prolonged receptor activation, however, has deleterious long-term effects leading to hypertrophy and the development heart failure. Here we investigate effect chronic receptors on excitation-contraction coupling (ECC) in ventricular cardiomyocytes from a previously characterized mouse model hyperactivity, which are genetically deficient adrenoceptor...
Chagasic cardiomyopathy (CCC) is one of the main causes heart failure and sudden death in Latin America. To date, there no available medication to prevent or reverse onset cardiac symptoms. CCC occurs a scenario disrupted calcium dynamics enhanced oxidative stress, which combined, may favor hyper activation calcium/calmodulin (Ca2+ /CaM)-calcium/calmodulin-dependent protein kinase II (CaMKII) /CaM-CaMKII) pathway, fundamental for physiology it implicated other diseases. Here, we evaluated...
ABSTRACT Objective: To recognize and address Patau’s syndrome, despite its rarity associated low life expectancy, through the presentation of a case study 2-year-old patient receiving Home Care services. Case description: We present female who defied odds with prolonged survival, possible due to Care. She was delivered via cesarean section at 31 weeks + 4 days restricted uterine growth. The mother, aged 36, had received proper prenatal care in good health. diagnosis syndrome confirmed...
Chagas disease (CD) is a neglected that induces heart failure and arrhythmias in approximately 30% of patients during the chronic phase disease. Despite major efforts to understand cellular pathophysiology CD there are still relevant open questions be addressed. In present investigation we aimed evaluate contribution Na+/Ca2+ exchanger (NCX) electrical remodeling isolated cardiomyocytes from an experimental murine model CD.Male C57BL/6 mice were infected with Colombian strain Trypanosoma...
Abstract Diminazene aceturate (DIZE) is an anti‐protozoan compound that has been previously reported to increase the activity of angiotensin‐converting enzyme 2 (ACE2) and thus Angiotensin‐(1‐7) production, leading cardioprotection against post‐myocardial infarction dysfunction structural remodelling. Moreover, DIZE able ameliorate morpho‐functional changes after myocardial by enhancing ACE2 activity, increasing production (a benefic peptide renin‐angiotensin system). However, despite...