A5051470893- Surgical site infection prevention
- Blood Coagulation and Thrombosis Mechanisms
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Childhood Cancer Survivors' Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Insect Resistance and Genetics
- Venomous Animal Envenomation and Studies
- Enhanced Recovery After Surgery
- Atrial Fibrillation Management and Outcomes
- Clinical Nutrition and Gastroenterology
- Entomopathogenic Microorganisms in Pest Control
- Amyotrophic Lateral Sclerosis Research
- Orthopedic Surgery and Rehabilitation
- Reconstructive Surgery and Microvascular Techniques
- Elbow and Forearm Trauma Treatment
- Safety Warnings and Signage
- Cholinesterase and Neurodegenerative Diseases
- Surgical Sutures and Adhesives
- Medical Malpractice and Liability Issues
- Transportation Safety and Impact Analysis
- Heparin-Induced Thrombocytopenia and Thrombosis
- S100 Proteins and Annexins
- Traffic and Road Safety
- Vascular Procedures and Complications
Cancer Research UK Clinical Trials Unit
2024
University of Birmingham
1989-2024
University of Otago
2023
Centre for Global Health Research
2022
National Institute for Health Research
2021
St. Louis County Missouri
2019
Washington University in St. Louis
2019
University of British Columbia
2001-2008
St. Paul's Hospital
2008
Kaplan (United States)
2003
A low molecular weight serine protease inhibitor (TAP) was purified from extracts of the soft tick, Ornithodoros moubata. The peptide is a slow, tight-binding inhibitor, specific for factor Xa (Ki = 0.588 +/- 0.054 nM). also acts as an anticoagulant in several human plasma clotting assays vitro. Its amino acid sequence (60 residues) has limited homology to Kunitz-type inhibitors. However, unlike other inhibitors this class, TAP inhibits only Xa. It had no effect at 300-fold molar excess on...
An in vivo thromboplastin (TP)-induced venous stasis thrombosis model rabbits was used to compare the efficacy of standard heparin with selective factor Xa inhibitors, recombinant tick anticoagulant peptide (rTAP) and antistasin (rATS), prophylactic prevention thrombus formation. Heparin significantly reduced TP-induced clot formation at doses 55 100 U kg-1h-1 yielding weights 9 +/- 4 6 2%, respectively. Clot decreased by i.v. infusions rTAP 21, 37 64 micrograms kg-1 min-1 resulting...
Tick anticoagulant peptide (TAP) is a potent, highly selective inhibitor of blood coagulation factor Xa (Waxman, L., Smith, D. E., Arcuri, K. and Vlasuk, G. P. (1990) Science, 248, 593-596). Further detailed studies pertaining to the in vitro vivo evaluation TAP require quantities which cannot be isolated from ticks. To overcome this limitation we describe here characterization recombinant (rTAP) secreted by Saccharomyces cerevisiae. Expression rTAP was obtained using chimeric gene...
In Brief Study Design. A retrospective cohort with cross- sectional follow-up. Objectives. The primary objective was to determine motor recovery in patients complete traumatic spinal cord injury (SCI). Secondary objectives included: 1) determining which factors predict local recovery, 2) assessing functional status using the Functional Independence Measure (FIM), and 3) generic health-related quality of life Short Form-36 (SF-36). Summary Background Data. Motor following SCI has been...
There are few descriptions of the surgical exposure ulnar aspect wrist. The anatomy dorsoulnar wrist was explored in 7 cadaver wrists with special attention to developing a approach dorsum radio-ulno-carpal joint. Using experience from previous authors and knowledge gained our cadaveric dissections, designed that provides wide anatomic layers dissected distinct pattern allows preservation extensor carpi ulnaris its sheath as well strong closure each layer restoration anatomy. Minimal...
Tick anticoagulant peptide (TAP) is a 60 amino acid protein which highly specific inhibitor of human blood coagulation factor Xa (fXa) isolated from the tick Ornithodoros moubata [Waxman, L., Smith, D. E., Arcuri, K. & Vlasuk, G. P. (1990) Science 248, 593-596]. Due to limited quantities native TAP, recombinant version TAP produced in Saccharomyces cerevisiae was used for detailed kinetic analysis inhibition interaction with fXa. rTAP determined be reversible, slow, tight-binding fXa,...
Magnetic resonance arthrography (MRA) has become the preferred modality for imaging patients with internal derangement of wrist. However, several aspects MRA use need to be clarified before a standardized approach wrist can developed. The objective study is evaluate efficiency different magnetic (MR) sequences in detection lesions triangular fibrocartilage complex (TFCC) and scapholunate lunotriquetral ligaments on direct MRA. Thirty-one consecutive arthrographic examinations using surface...
Telemedicine is being adopted for postoperative surveillance but requires evaluation efficacy. This study tested a telephone Wound Healing Questionnaire (WHQ) to diagnose surgical site infection (SSI) after abdominal surgery in low- and middle-income countries.
Recombinant tick anticoagulant peptide (rTAP) is a highly selective inhibitor of blood coagulation factor Xa. rTAP has been characterized kinetically as slow, tight-binding, competitive the enzyme. We used an approach consisting both recombinant, site-directed mutagenesis and solid-phase chemical synthesis to generate 31 independent mutations in identify those regions molecule which contribute specific, high-affinity binding interaction with Our results demonstrate that four amino-terminal...
Background Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig´s disease, is a rare neurological condition and the most common motor neurone disease. It fatal disease with specific loss of neurons in spinal cord, brain stem, cortex leading to progressive paralysis usually death within five years diagnosis. There remains no cure for ALS, management focused on combination neuroprotective medication, respiratory support, by multidisciplinary clinics. Patients methods This prospective,...
Abstract Background Surgical site infection (SSI) represents a major burden for patients, doctors, and health systems around the world. The aim of this trial is to assess whether practice using separate sterile gloves instruments close wounds at end surgery compared current routine hospital can reduce surgical 30-days post-surgery patients undergoing clean-contaminated, contaminated, or dirty abdominal surgery. Methods This study protocol describes pragmatic, international, multi-centre,...
Although parenteral nutrition is frequently administered to children undergoing treatment for malignancy, the use of naso‐gastric feeding had been little studied. A randomized, controlled trial supplementary in with newly diagnosed malignancy was therefore performed. Results showed that, contrary popular belief, acceptable and tolerated by even shortly after diagnosis welcomed their parents. Naso‐gastric increased energy intake, promoted improvement nutritional status as measured mid‐upper...
Arginine thiobenzyl esters are convenient chromogenic substrates of factor VIIa (Z-Arg-SBzl, Kcat/KM = 1,600 M-1 s-1) and were used to study the kinetics inhibition by several mechanism-based isocoumarin inhibitors trypsin-like enzymes. Isocoumarin derivatives substituted with a 7-guanidino or 3-isothiureidopropoxy group good acted as anticoagulants in human rabbit plasma. With normal citrated plasma, 4-chloro-3-ethoxy-7-guanidinoisocoumarin (3) 7-amino-4-chloro-3-(3-isothiureidopropoxy)...
Anthropometric data, although easily collected, are readily misinterpreted. This article presents guidelines for applying anthropometric methods to the assessment of nutritional status children. The importance converting raw data into age‐ and sex‐independent scores is emphasized. A compilation sources reference standards given various presenting comparing population discussed.