Abstract BACKGROUND The current study was conducted to characterize the risks and clinical consequences of oral mucositis (OM) in patients with head neck carcinoma (HNC) who are receiving radiation therapy. METHODS Data regarding 450 HNC had received therapy were collected via chart review from 154 U.S. medical oncologists. Information obtained included patient characteristics, treatments received, highest recorded grade OM during (none, mild, moderate, or severe), outcomes potentially...

OBJECTIVE—To compare the incidence of heart failure in individuals with type 2 diabetes receiving thiazolidinediones (TZDs) versus other oral antihyperglycemic agents. RESEARCH DESIGN AND METHODS—We conducted a retrospective cohort study using health insurance claims database. The sample included patients who received an agent between January 1995 and March 2001. Those any for TZDs were designated “exposed,” each was compared five randomly selected unexposed patients. diagnoses or digoxin...

Objective: To assess the association between adherence with fluticasone propionate/salmeterol combination (FSC) product in a single inhaler and asthma care utilization costs patients typical US clinical practice.

Contrary to the approved indication for pegfilgrastim prophylaxis, some patients receive it on same day as last administration of chemotherapy in clinical practice, which could adversely impact risk febrile neutropenia (FN). An evaluation timing prophylaxis and FN was undertaken. A retrospective cohort design data from two US private health care claims repositories were employed. Study population comprised adults who received intermediate/high-risk regimens solid tumors or non-Hodgkin's...

Acute myeloid leukemia (AML) is associated with high disease burden. This analysis estimated HRU and costs among newly diagnosed AML patients in a US commercially insured population.This was retrospective observational study using the IMS Health PharMetrics Plus Hospital Charge Detail Master databases. Patients included adults who were between January 2007 June 2016 ("study period"). <12 months of continuous enrollment prior to index date excluded, as those whose first diagnosis...

Purpose. The 90-day risk of venous thromboembolism (VTE) among medically ill patients admitted to a hospital was estimated and is discussed. Summary. Patients aged ≥40 years who were hospitalized between January 1, 1998, June 30, 2002, for reasons other than traumatic injury, labor delivery, mental disorder, or VTE did not undergo surgery identified in large U.S. healthcare claims database. receiving anticoagulants the period preceding admission excluded. We percentage study subjects...

Background: Patients with myelodysplastic syndrome (MDS) and other acquired hematopoietic disorders frequently require chronic transfusion therapy. Although red cell transfusions are known to cause iron overload, data on the risk of iron-related complications in these patients limited.Methods: This was a retrospective, case-control study assess association between exposure overload MDS using large US health-insurance claims database spanning 1997–2004. Subjects included members one or more...

BACKGROUND Venous thromboembolism (VTE) is a frequent and potentially costly complication of major orthopedic surgery. OBJECTIVE To estimate the economic consequences VTE following METHODS Using large healthcare claims database, we identified all patients who underwent total hip replacement, knee surgery, or fracture repair from January 1993 to December 1998. Patients with clinical (cases) were based on diagnosis deep vein thrombosis pulmonary embolism within 90 days surgery (index...

Background:Patients with bone metastases secondary to breast cancer are pre-disposed skeletal-related events (SREs), including spinal cord compression (SCC), pathologic fracture (PF), surgery (SB), and radiotherapy (RT).Objective:To document current patterns of healthcare utilization costs SREs in patients metastases.Methods:This was a retrospective, observational study using the Thomson MedStat MarketScan Commercial Claims Encounters database from 9/2002 6/2011. Study subjects included all...

Aim: To estimate treatment patterns and healthcare costs among triple-class exposed relapsed refractory multiple myeloma (RRMM) patients. Materials & methods: Eligible patients had ≥1 line of therapy (LOT) each proteasome inhibitors, immunomodulatory drugs daratumumab in December 2015–September 2018 received a new LOT. Results: A total 154 were included with median follow-up 6.2 months. Median time from diagnosis to LOT was 41.0 Kaplan–Meier discontinuation 4.2 Mean per-patient, per-month...

Abstract Deferoxamine mesylate (DFO) reduces morbidity and mortality associated with transfusional iron overload. Data on the utilization costs of care among U.S. patients receiving DFO in typical clinical practice are limited however. This was a retrospective study using large health insurance claims database spanning 1/97–12/04 representing 40 million members &gt;70 plans. Study subjects ( n = 145 total, 106 sickle cell disease [SCD], 39 thalassemia) included diagnosis thalassemia or SCD,...

To evaluate the cost-effectiveness of blinatumomab (Blincyto) vs standard care (SOC) chemotherapy in adults with relapsed or refractory (R/R) Philadelphia-chromosome-negative (Ph-) B-precursor acute lymphoblastic leukemia (ALL) based on results phase 3 TOWER study from a US healthcare payer perspective.The Blincyto Global Economic Model (B-GEM), partitioned survival model, was used to estimate incremental ratio (ICER) SOC. Response rates, event-free (EFS), overall (OS), numbers cycles and...

Objective: To compare risk of hospitalization or emergency department (ED) visit and healthcare costs in patients with chronic bronchitis initiating inhaled maintenance therapy fluticasone propionate/salmeterol 250/50 mcg combination (FSC) versus other therapies.Design methods: This retrospective cohort study assessed 9 217 from the PharMetrics administrative claims database enrolled July 1997 to January 2005. Study subjects were persons medical diagnoses (ICD-9-CM 491.xx) who also had...

Cancer patients with bone metastases (BMets) are predisposed to skeletal complications. Bone-targeted therapies such as denosumab or intravenous bisphosphonates (IVBs) reduce the risk of these This study characterized patterns IVB use in USA.This was a retrospective, observational using Truven Health MarketScan(®) Commercial and Medicare databases (2002-2011). Subjects ≥1 claims diagnosis breast, lung, prostate cancer (BC, LC, PC) BMets were included. The date first BMet claim "index date."...

Effects of disease progression on healthcare resource utilization (HRU) and costs among multiple myeloma (MM) patients with ≥1 line therapy (LOT) without receipt stem cell transplant were estimated using large US claims database. Disease was defined as advancement to the next LOT, bone metastasis, hypercalcemia, soft tissue plasmacytoma, skeletal related events, acute kidney failure, or death within 12 months LOT initiation. Annual HRU in first four LOTs compared for versus inverse...

To estimate the costs of adverse events (AEs) in patients aged ≥65 years with metastatic renal cell carcinoma (mRCC).Retrospective study using linked Surveillance, Epidemiology and End Results (SEER) Medicare database. Study subjects consisted persons SEER-Medicare, years, evidence newly diagnosed mRCC between January 1, 2007 December 31, 2007. Adverse interest Grade 3 or 4 toxicities that have been reported frequency ≥5% randomized controlled trials sunitinib, sorafenib, bevacizumab,...

Clinical guidelines recommend add-on therapy with long-acting beta2-agonists (LABA) in patients mild-to-moderate persistent asthma whose disease is not adequately controlled inhaled corticosteroids (ICSs) alone. For those achieving control therapy, careful reduction ICS dose followed by withdrawal of LABA recommended. This study was designed to compare asthma-related outcomes receiving fluticasone propionate/salmeterol combination (FSC) who stepped down a lower FSC versus propionate (FP) at...

Background:Observational studies suggest that single-tablet formulations are associated with improved adherence versus the same components taken as separate tablets. The objective of this study was to compare in patients Parkinson's disease (PD) receiving levodopa therapy levodopa/carbidopa/entacapone tablets (LCE) levodopa/carbidopa (LC) and entacapone (E) (LC E).Methods:This a retrospective, observational cohort using large health insurance claims database. Subjects included persons PD...

Alpha-1 antitrypsin deficiency (AATD) is caused by mutations in SERPINA1, which encodes alpha-1 antitrypsin, a protease inhibitor (Pi). Individuals with AATD and the homozygous Pi*ZZ genotype have variable risk of progressive liver disease but influence comorbid lung poorly understood.To characterise patients (AATD-LD-Pi*ZZ) or without describe disease-related clinical events longitudinally.This was an observational cohort study Mayo Clinic Healthcare System (January 2000-September 2021)....