A5011124800- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Enzyme Production and Characterization
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- HIV/AIDS drug development and treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- DNA and Nucleic Acid Chemistry
- Enzyme function and inhibition
- Metal-Organic Frameworks: Synthesis and Applications
- Synthesis and biological activity
- Neuroscience and Neuropharmacology Research
- Advanced NMR Techniques and Applications
- Nuclear Receptors and Signaling
- Advanced Nanomaterials in Catalysis
- Genomics, phytochemicals, and oxidative stress
- Molecular Sensors and Ion Detection
- Pharmaceutical Economics and Policy
- Protein Hydrolysis and Bioactive Peptides
- Biochemical and biochemical processes
- Phytochemicals and Antioxidant Activities
- Chemical Reactions and Mechanisms
- Zeolite Catalysis and Synthesis
- Mitochondrial Function and Pathology
- Antioxidant Activity and Oxidative Stress
Universidade do Porto
2016-2024
University of Cagliari
2019-2023
KLE Technological University
2022
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2021
University of Aveiro
2018
Neurodegenerative diseases (NDs) are a set of progressive, chronic, and incurable characterized by the gradual loss neurons, culminating in decline cognitive and/or motor functions. Alzheimer’s disease (AD) Parkinson’s (PD) most common NDs represent an enormous burden both terms human suffering economic cost. The available therapies for AD PD only provide symptomatic palliative relief limited period unable to modify diseases’ progression. Over last decades, research efforts have been focused...
Alzheimer's disease (AD) is a multifactorial age-related associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS restoring transmission can be an effective therapeutic strategy toward AD. Herein, we report for the first time dual-target hydroxybenzoic acid (HBAc) derivatives acting as mitochondriotropic antioxidants cholinesterase (ChE) inhibitors. The studies were performed two AntiOxBEN1 (catechol derivative), AntiOxBEN2...
The infections by multidrug-resistant bacteria are a growing threat to human health, and the efficacy of available antibiotics is gradually decreasing. As such, new antibiotic classes urgently needed.This study aims evaluate antimicrobial activity, safety mechanism action phytochemical-based triphenylphosphonium (TPP+) conjugates.A library TPP+ conjugates was repositioned extended, its activity evaluated against panel Gram-positive (methicillin-resistant Staphylococcus aureus - MRSA)...
The wealth of site-selective structural information on CO2 speciation, obtained by spectroscopic techniques, is often hampered the lack easy-to-control synthetic routes. Herein, an alternative experimental protocol that relies high sensitivity 13 C chemical shift anisotropy (CSA) tensors to proton transfer, presented unambiguously distinguish between ionic/charged and neutral species, formed upon adsorption in amine-modified porous materials. Control surface amine spacing was achieved...
Although the lipophilic triphenylphosphonium (TPP+) cation is widely used to target antioxidants mitochondria, TPP+-based derivatives have shown cytotoxicity in several biological vitro models. We confirmed that Mito.TPP cytotoxic both human neuronal (SH-SY5Y) and hepatic (HepG2) cells, decreasing intracellular adenosine triphosphate (ATP) levels, leading mitochondrial membrane depolarization reduced mass after 24 h. surpassed this concern using nitrogen-derived cationic carriers (Mito.PICO,...
Neurodegenerative diseases (NDs) are a set of progressive, chronic, and incurable characterized by the gradual loss neurons, culminating in decline cognitive and/or motor functions. Alzheimer’s disease (AD) Parkinson’s (PD) most common NDs represent an enormous burden both terms human suffering economic cost. The available therapies for AD PD only provide symptomatic palliative relief limited period unable to modify diseases’ progression. Over last decades, research efforts have been focused...
Media optimization studies and production of adenosylcobalamin (Vitamin B12) by environment friendly organism Rhizobium sppNeha Nohwar, Rahul V. Khandare, Neetin S. Desai
A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides (EMAC8002a-m) was designed and synthesised to evaluate the effect substituents in positions 3 4 dihydrothiazole ring on inhibitory potency selectivity toward human carbonic anhydrase isoforms I, II, IX, XII. Most new compounds preferentially inhibit II Both electronic steric features aryl substituent position concur determine overall biological activity these derivatives.
Tumour associated carbonic anhydrases (CAs) IX and XII have been recognised as potential targets for the treatment of hypoxic tumours. Therefore, considering high pharmacological chromene scaffold selective ligand isoforms, two libraries compounds, namely 2H-chromene 7H-furo-chromene derivatives, with diverse substitution patterns were designed synthesised. The structure newly synthesised compounds was characterised their inhibitory potency selectivity towards human CA off target isoforms I,...
Current therapeutic protocols for the treatment of HIV infection consist combination diverse anti-retroviral drugs in order to reduce selection resistant mutants and allow use lower doses each single agent toxicity. However, avoiding interactions patient compliance are issues not fully accomplished so far. Pursuing on our investigation potential anti multi-target agents we have designed synthesized a small library biphenylhydrazo 4-arylthiazoles derivatives evaluated investigate ability new...
A new library of non-nitrocatechol compounds (HetCAMs) was developed and their efficacy compared to tolcapone, a standard COMT inhibitor for PD. Compound
The present study reports production, partial purification, and media optimization for alkaline protease using Bacillus cereus PW3A. A profiling production indicates maximum enzyme activity (17.22 U/ml) was observed after 48 h of incubation. studies also showed that the increased with decrease in carbon content indicating growth associated nature production. Partial purification done ammonium sulfate precipitation dialysis. Further were conducted to assess significant ingredients influencing...
Current therapeutic protocols for the treatment of HIV infection consist combination diverse anti-retroviral drugs in order to reduce selection resistant mutants and allow use lower doses each single agent toxicity. However, avoiding interactions patient compliance are issues not fully accomplished so far. In this respect identification agents with multitarget potential might represent ideal solution. Accordingly, a small library biphenylhydrazo 4-arylthiazoles derivatives has been...