A5082603948- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Enzyme function and inhibition
- Alzheimer's disease research and treatments
- Free Radicals and Antioxidants
- Synthesis and Catalytic Reactions
- Cancer Treatment and Pharmacology
- Synthesis and Reactivity of Heterocycles
- Histone Deacetylase Inhibitors Research
- Microbial Natural Products and Biosynthesis
- Edible Oils Quality and Analysis
- Crystal structures of chemical compounds
- Cytokine Signaling Pathways and Interactions
- Crystallization and Solubility Studies
- Antioxidant Activity and Oxidative Stress
- Microbial metabolism and enzyme function
- Synthesis and Biological Evaluation
- Pharmacological Effects of Natural Compounds
- Berberine and alkaloids research
- Carbon dioxide utilization in catalysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Chemistry and Chemical Engineering
University of Bari Aldo Moro
2024
Magna Graecia University
2018-2021
Universidade do Porto
2019-2021
Monoamine oxidases A and B (MAO A, B) are ubiquitous enzymes responsible for oxidative deamination of amine neurotransmitters xenobiotics. Despite decades studies, MAO inhibitors (MAOIs) find today limited therapeutic space as second-line drugs the treatment depression Parkinson's disease. In recent years, a renewed interest in MAOIs has been raised up by several studies investigating role MAOs, particularly tumor insurgence progression, efficacy coadjutants therapy chemoresistant tumors....
Alzheimer's disease (AD) is a multifactorial age-related associated with oxidative stress (OS) and impaired cholinergic transmission. Accordingly, targeting mitochondrial OS restoring transmission can be an effective therapeutic strategy toward AD. Herein, we report for the first time dual-target hydroxybenzoic acid (HBAc) derivatives acting as mitochondriotropic antioxidants cholinesterase (ChE) inhibitors. The studies were performed two AntiOxBEN1 (catechol derivative), AntiOxBEN2...
Chromone-3-phenylcarboxamides (Crom-1 and Crom-2) were identified as potent, selective, reversible inhibitors of human monoamine oxidase B (hMAO-B). Since they exhibit some absorption, distribution, metabolism, excretion (ADME)-toxicity liabilities, new derivatives synthesized to map the chemical structural features that compose pharmacophore, a process vital for lead optimization. Structure–activity relationship data, supported by molecular docking studies, provided rationale contribution...
Mushrooms can be considered a valuable source of natural bioactive compounds with potential polypharmacological effects due to their proven antimicrobial, antiviral, antitumor, and antioxidant activities. In order identify new anticancer compounds, an in-house chemical database molecules extracted from both edible non-edible fungal species was employed in virtual screening against the isoform 7 Histone deacetylase (HDAC). This target is known implicated different cancer processes, particular...
The tumor-associated isoenzymes hCA IX and XII catalyze the hydration of carbon dioxide to bicarbonate protons. These isoforms are highly overexpressed in many types cancer, where they contribute acidification tumor environment, promoting cell invasion metastasis. In this work, order identify novel dual inhibitors, virtual screening techniques biological assays were combined. A structure-based towards was performed using a database approximately 26,000 natural compounds. best shared hits...
The tumour-associated isoenzymes, hCA IX and XII catalyze the hydration of carbon dioxide to bicarbonate protons. These isoforms are highly overexpressed in many types cancer, where they contribute for acidification tumor environment promoting cell invasion metastasis. In this work, order identify novel dual inhibitors, virtual screening techniques biological assays were combined. A structure based towards was performed using a database approximately 26000 natural compounds. best shared hits...
The structure of the title quinoline carboxamide derivative, C 26 H 25 N 3 O, is described. moiety not planar as a result slight puckering pyridine ring. secondary amine has slightly pyramidal geometry, certainly planar. Both intra- and intermolecular hydrogen bonds are present. Hirshfeld surface analysis lattice energies were used to investigate interactions.