A5024144799- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Atherosclerosis and Cardiovascular Diseases
- Dermatology and Skin Diseases
- Cardiovascular Health and Disease Prevention
- Urticaria and Related Conditions
- Inflammatory Bowel Disease
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Otitis Media and Relapsing Polychondritis
- Platelet Disorders and Treatments
- IL-33, ST2, and ILC Pathways
- Retinal and Optic Conditions
- Liver Diseases and Immunity
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Salivary Gland Disorders and Functions
- Complement system in diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of Palermo
2011-2023
Center for Rheumatology
2001-2018
Ospedale Vincenzo Cervello
2014-2018
Boehringer Ingelheim (Australia)
2016
Amsterdam UMC Location University of Amsterdam
2016
University of Amsterdam
2016
Bristol-Myers Squibb (Germany)
2016
Janssen (Belgium)
2016
Roche (Switzerland)
2016
Pfizer (United Kingdom)
2016
Abstract Objective To compare the 2 most efficacious therapeutic regimens, intravenous immunoglobulin (IVIG) and anticoagulation with low molecular weight (LMW) heparin plus low‐dose aspirin, in women recurrent pregnancy loss associated antiphospholipid antibodies (aPL). Methods We examined 40 abortion (at least 3 occurrences) repeatedly positive test results for anticardiolipin or lupus anticoagulant. The subjects were randomly assigned to treatment IVIG LMW aspirin. Both therapies started...
In chronic inflammatory disorders, interleukin (IL)-22 may act either as a protective or pro-inflammatory cytokine. At mucosal sites, IL-22 is mainly produced by CD4(+) T cells and subset of natural killer (NK) expressing the receptor NKp44 (NKp44(+) NK cells). The aim this study was to investigate expression in salivary glands patients with primary Sjögren's syndrome (pSS).Minor gland biopsies were obtained from 19 pSS 16 non-specific sialoadenitis. Quantitative gene analysis TaqMan...
Objective To investigate the expression and tissue distribution of Th9‐related cytokines in patients with psoriatic arthritis (PsA). Methods Quantitative gene analysis Th1, Th17, Th9 was performed intestinal biopsy samples obtained from PsA, HLA−B27−positive ankylosing spondylitis (AS), Crohn's disease (CD), healthy controls. Expression interleukin‐23 (IL‐23), IL‐17, IL‐22, IL‐9, IL‐9 receptor (IL‐9R) were evaluated by immunohistochemistry confocal microscopy. Flow cytometry used to study...
Cytokines such as tumour necrosis factor (TNF)-α, interleukin (IL)-12, interferon (IFN)-γ, IL-23 and, more recently, IL-9, have been implicated in the initiation/maintenance of inflammation psoriasis and psoriatic arthritis (PsA). In present study we aimed to characterize role γδ T cells peripheral blood synovial fluid PsA patients investigate their response in-vitro stimulation with antigen or cytokines (IL-9 IL-23). isolated from mononuclear were analysed by flow cytometry evaluate...
Subclinical gut inflammation has been demonstrated in patients with ankylosing spondylitis (AS). This study was undertaken to determine the frequency of regulatory CD4+CD25(high) T cells (Treg cells) and evaluate Treg cell-related cytokines (interleukin-2 [IL-2], transforming growth factor β [TGFβ], IL-10) transcription factors (FoxP3 STAT-5) ileum AS.Quantitative gene expression analysis, by reverse transcriptase-polymerase chain reaction, Treg-related (IL-2, TGFβ, (STAT-5 FoxP3) performed...
The aim of this study was to evaluate the role rituximab (RTX) in modulating expression IL-17/IL-23 pathway salivary glands (SGs) patients with primary SS (pSS).Consecutive SG biopsies were obtained from 15 pSS before and after 1 year RTX therapy. IL-17, IL-23p19 p-STAT3 evaluated by immunohistochemistry at baseline mast cells Th17 response immunologic effect on also studied vitro experiments.IL-17 overexpressed SGs mainly infiltrating T cells. After therapy, but not p-STAT3, significantly...
A novel carrier system based on halloysite nanotubes (HNT), for the potential intraarticular delivery of kartogenin (KGN) by means laponite (Lap) hydrogel (HNT/KGN/Lap), is developed. The drug was first loaded into HNT, and hybrid composite obtained used as filler hydrogel. Both were thoroughly investigated several techniques morphology imaged transmission electron microscopy. Furthermore, gelating ability in presence rheological properties also investigated. kinetic release from HNT HNT/Lap...
Objectives. Subclinical gut inflammation has been demonstrated in patients with AS. Altered expression of paneth cell (PC) anti-microbial peptides have reported the inflamed ileum Crohn's disease (CD). Here, we investigated PC-derived subclinical Methods. Multiple adjacent mucosal biopsies from terminal were obtained 25 AS, 30 CD and 15 healthy controls (HCs). Expression human α-defensin 5 (HD-5), phospholipase A2 (PLA2), lysozyme SOX-9 molecules was assessed by quantitative Taqman RT–PCR on...
Giant cell (temporal) arteritis (GCA) is a vasculitis that mainly affects the large and medium arteries, especially branches of proximal aorta. Interleukin-32 (IL-32) recently described Th1 proinflammatory cytokine, induced by interferon-γ (IFNγ), IL-1β, tumor necrosis factor α (TNFα). This study was undertaken to investigate expression tissue distribution IL-32 in artery biopsy specimens from patients with GCA.Quantitative gene analysis IL-32, TNFα, IFNγ, IL-6, IL-27 performed obtained 18...