A5011401096- Emergency and Acute Care Studies
- Global Maternal and Child Health
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Genomics, phytochemicals, and oxidative stress
- Sepsis Diagnosis and Treatment
- Child Nutrition and Water Access
- Non-Invasive Vital Sign Monitoring
- Healthcare Policy and Management
- Respiratory Support and Mechanisms
- Maternal and Neonatal Healthcare
- Metabolism, Diabetes, and Cancer
- Healthcare Technology and Patient Monitoring
- Mycotoxins in Agriculture and Food
- Delphi Technique in Research
- Trauma and Emergency Care Studies
- Social Issues and Policies
- Viral Infections and Outbreaks Research
- Infant Development and Preterm Care
- Glutathione Transferases and Polymorphisms
- Nitrogen and Sulfur Effects on Brassica
- Ultrasound in Clinical Applications
- Maternal and fetal healthcare
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
University of British Columbia
2022-2025
B.C. Women's Hospital & Health Centre
2024-2025
British Columbia Children's Hospital
2022-2024
Western Cape Department of Health
2024
Stellenbosch University
2024
Children's & Women's Health Centre of British Columbia
2023-2024
University of KwaZulu-Natal
2018-2023
Pneumonia is the leading cause of death in children globally. In low- and middle-income countries (LMICs) pneumonia diagnosis relies on accurate assessment respiratory rate, which can be unreliable when completed by nurses with less-advanced training. To inform more measurements, we investigate repeatability RRate app used Ugandan district hospitals. This secondary analysis included 3,679 aged 0–5 years. The dataset had two sequential measurements rate collected 14 using app. We measured...
Sepsis occurs predominantly in low-middle-income countries. Sub-optimal triage contributes to poor early case recognition and outcomes from sepsis. Improved quality of care can lead improved outcomes. We evaluated the impact Smart Triage using time intravenous antimicrobial administration a multisite interventional study. Triage, digital platform with risk score clinical dashboard, was implemented (with control sites) Kenya (February 2021-December 2022) Uganda (April 2020-April 2022)....
Models for digital triage of sick children at emergency departments hospitals in resource poor settings have been developed. However, prior to their adoption, external validation should be performed ensure generalizability. We externally validated a previously published nine-predictor paediatric model (Smart Triage) developed Uganda using data from two Kenya. Both discrimination and calibration were assessed, recalibration was by optimizing the intercept classifying patients into emergency,...
Abstract Patulin (PAT) is a common mycotoxin contaminant of apple products linked to impaired metabolic and kidney function. Adenosine monophosphate activated protein kinase (AMPK), abundantly expressed in the kidney, intercedes changes renal injury. The alpha-1-adrenergic receptors (α 1 -AR) facilitate Epinephrine (Epi)-mediated AMPK activation, linking metabolism Preliminary molecular docking experiments examined potential interactions AMPK-gamma subunit 3 (PRKAG3). effect PAT exposure...
Abstract Background Effective triage at hospitals can improve outcomes for children globally by helping identify and prioritize care those most at-risk of death. Paper-based pediatric guidelines have been developed to support frontline health workers in low-resource settings, but these be challenging implement. Smart Triage is a digital triaging platform quality improvement (QI) that aims address this challenge. represents major cultural behavioural shift terms managing patients facilities...
Several triage systems have been developed, but little is known about their performance in low-resource settings. Evaluating and comparing novel to existing scales provides essential information added value, reliability, safety, effectiveness before adoption. This study included children aged < 15 years who presented the emergency departments of two public hospitals Kenya between February December 2021. We compared Emergency Triage Assessment Treatment ( ETAT ) guidelines Smart (ST)...
HIV has been implicated in adverse birth outcomes, due to increased oxidative stress and inflammation. In addition, reported increase nitric oxide levels. Therefore the combined exposures traffic-related air pollution, within South Durban, Africa (SA), may lead outcomes. However, exact mechanism is still unknown; this study aimed identify a potential mechanism. First, influence of on nitrosative markers pregnant women was assessed. Secondly, effect these makers exposure oxides nitrogen (NOx)...
In low- and middle-income countries, health workers use pulse oximeters for intermittent spot measurements of oxygen saturation (SpO2). However, the accuracy reliability have not been determined. We evaluated repeatability ideal observation time to guide recommendations during check measurements.Two 1-minute were taken 3,903 subjects enrolled in study conducted April 2020-January 2022 Uganda, collecting 1 Hz SpO2 signal quality index (SQI) data. The between 2 was assessed using an intraclass...
Sepsis, characterized by organ dysfunction due to presumed or proven infection, has a case-fatality over 20% in severe cases low-and-middle income countries. Early diagnosis and treatment have benefits, prompting our implementation of Smart Triage at Jinja Regional Referral Hospital Uganda, program that expedites through data-driven triage platform. We conducted cost-effectiveness analysis explore its impact on patients inform multicenter scale up.The parent clinical trial for was pre-post...
Abstract Sepsis occurs predominantly in low-middle-income countries. Sub-optimal triage contributes to poor early case recognition and outcomes from sepsis. We evaluated the impact of Smart Triage using improved time intravenous antimicrobial administration a multisite interventional study. was implemented (with control sites) Kenya (February 2021-December 2022) Uganda (April 2020-April 2022). Children presenting outpatient departments with an acute illness were enrolled. A controlled...
Abstract Background Pneumonia is the leading cause of death in children globally. In low- and middle-income countries diagnosis pneumonia relies heavily on an accurate assessment respiratory rate, which can be unreliable nurses clinicians with less advanced training. order to inform more measurements, we investigate repeatability RRate app used by district hospitals Uganda. Methods This secondary analysis included 3679 aged 0-5 years. The dataset had two sequential measurements rate using...
In September 2015, South Africa (SA) and 192 countries adopted Agenda 2030, which included the Sustainable Development Goals. With a mere 6 years to go before it is useful understand what progress SA making towards their attainment. this short report, we assess meeting maternal mortality target, globally in SA. The ratio that are expected reach no more than 70 deaths per 100 000 live births. A range of sources used show progress, with an emphasis on reports National Committee Confidential...
Infectious diseases in neonates account for half of the under-five mortality low- and middle-income countries. Data-driven algorithms such as clinical prediction models can be used to efficiently detect critically ill children order optimize care reduce mortality. Thus far, only a handful have been externally validated are limited neonatal in-hospital The aim this study is validate previously derived model (Smart Triage) using combined prospective baseline cohort from Uganda Kenya with...
Sub-Saharan Africa accounts for two-thirds of the global burden maternal and newborn deaths. Adverse outcomes among postpartum women newborns occurring in first six weeks life are often related, though data co-examining patients limited. This study is an exploratory analysis describing epidemiology postnatal complications following facility birth discharge Mbarara, Uganda. single-site prospective cohort observational enrolled facility-based delivery. To capture health information about both...
Abstract Introduction Models for digital triage of sick children at emergency departments hospitals in resource poor settings have been developed. However, prior to their adoption, external validation should be performed ensure generalizability. Methods We externally validated a previously published nine-predictor paediatric model (SMART Triage) developed Uganda using data from two Kenya. Both discrimination and calibration were assessed, recalibration was by optimizing the intercept...
Abstract Several triage systems have been developed, but little is known about their performance in low-resource settings. Evaluating and comparing novel to existing scales provides essential information added value, reliability, safety, effectiveness before adoption. This prospective observational study included children aged < 15 years who presented the emergency departments of two public hospitals Kenya between February December 2021. We compared Emergency Triage Assessment Treatment (...
Introduction In low-income country settings, the first six weeks after birth remain a critical period of vulnerability for both mother and newborn. Despite recommendations routine follow-up delivery facility discharge, few mothers newborns receive guideline recommended care during this period. Prediction modelling post-delivery outcomes has potential to improve newborn by identifying high-risk dyads, improving risk communication, informing patient-centered approach postnatal interventions....
Pillay, Y.; Dunsmuir, D.; Pallot, K.; Wiens, M. O.; Agaba, C.; Rigg, J.; Novakowski, S. Tagoola, A.; Kissoon, N.; Ansermino, J. Author Information
Non-communicable diseases (NCDs) have risen rapidly worldwide, sparking interest in causative agents and pathways. Patulin (PAT), a xenobiotic found fruit products contaminated by molds, is postulated to be diabetogenic animals, but little known about these effects humans. This study examined the of PAT on insulin signaling pathway pyruvate dehydrogenase complex (PDH). HEK293 HepG2 cells were exposed normal (5 mM) or high (25 glucose levels, (1.7 nM) (0.2 μM; 2.0 μM) for 24 h. The qPCR...
Abstract Age is an important risk factor among critically ill children with neonates being the most vulnerable. Clinical prediction models need to account for age differences and must be externally validated updated, if necessary, enhance reliability, reproducibility, generalizability. We Smart Triage model using a combined prospective baseline cohort from three hospitals in Uganda two Kenya admission, mortality, readmission. evaluated discrimination area under receiver-operator curve...