A5014350523- Respiratory viral infections research
- Virology and Viral Diseases
- HIV Research and Treatment
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Nanocluster Synthesis and Applications
- Synthesis and Biological Evaluation
- Influenza Virus Research Studies
- Insect Resistance and Genetics
- Antibiotic Resistance in Bacteria
- Viral Infections and Vectors
- Hepatitis C virus research
- Signaling Pathways in Disease
- Advanced biosensing and bioanalysis techniques
- Congenital Diaphragmatic Hernia Studies
- Synthesis and biological activity
- Lipid metabolism and disorders
- Clostridium difficile and Clostridium perfringens research
- Pneumocystis jirovecii pneumonia detection and treatment
- Carbon and Quantum Dots Applications
- Alcohol Consumption and Health Effects
- Mosquito-borne diseases and control
- Carbohydrate Chemistry and Synthesis
- Plant Pathogenic Bacteria Studies
Birla Institute of Technology and Science, Pilani
2019-2024
Birla Institute of Technology and Science, Pilani - Goa Campus
2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2024
Christ University
2023
AstraZeneca (United States)
2020-2022
NGM Biopharmaceuticals (United States)
2020
Serimmune (United States)
2017
Stony Brook University
2010-2014
University of Wisconsin–Madison
2007-2010
St. Xavier's College (Autonomous)
1948-1949
The trans-fat containing AMLN (amylin liver non-alcoholic steatohepatitis, NASH) diet has been extensively validated in C57BL/6J mice with or without the Lepob/Lepob (ob/ob) mutation leptin gene for reliably inducing metabolic and histopathological changes recapitulating hallmarks of NASH. Due to a recent ban on trans-fats as food additive, there is marked need developing new capable promoting compatible level disease ob/ob mice.To develop biopsy-confirmed mouse model NASH based an...
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children, resulting in annual epidemics worldwide. INFORM-RSV a multiyear clinical study designed to describe global molecular epidemiology RSV children under 5 years age by monitoring temporal geographical evolution current circulating strains, F protein antigenic sites, their relationships with features disease. During pilot season (2017–2018), 410 G-F gene sequences were...
Abstract HCV reoccurs after liver transplantation and increases mortality. Cyclosporine, but not tacrolimus, has potent antiviral effects against replication in cell culture. To determine the conditions, if any, under which is susceptible to cyclosporine vivo , we selected for cyclosporine-resistant mutant vitro . The resulting mutations were mapped x-ray crystallographic structures sequence databases. Mutations by clustered nonstructural (NS) proteins NS5A NS5B. Different sets of NS5A,...
We have determined that, in addition to its receptor-destroying activity, the influenza virus neuraminidase is capable of efficiently forming virus-like particles (VLPs) when expressed individually from plasmid DNA. This observation applies both human subtypes neuraminidase, N1 and N2. However, it not found with every strain virus. Through gain-of-function loss-of-function analyses, a critical determinant within ectodomain was identified that contributes VLP formation but sufficient...
Hepatitis C Virus (HCV) infection is a leading indication for liver transplantation. HCV reoccurs almost universally post transplant, decreasing both graft longevity and patient survival. The immunosuppressant, cyclosporine A (CsA) has potent anti-HCV activity towards replicons the genotype 2a cell culture infectious virus. Previously, we isolated mutations in 1bN replicon with less sensitivity to CsA that mapped NS5A NS5B regions of Mutations alone conferred decreased susceptibility...
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children. To date, no vaccine approved for broad population healthy infants. MEDI8897, a potent anti-RSV fusion antibody with extended serum half-life, currently under clinical investigation as potential passive RSV all As ribonucleic acid virus, prone to mutation, possibility viral escape from MEDI8897 neutralization concern. We generated monoclonal (mAb)-resistant mutants...
ABSTRACT A live attenuated bovine parainfluenza virus type 3 (PIV3), harboring the fusion (F) and hemagglutinin-neuraminidase (HN) genes of human PIV3, was used as a vector to express surface glycoproteins derived from two pathogens, metapneumovirus (hMPV) respiratory syncytial (RSV). RSV hMPV are both paramyxoviruses that cause disease in young children, elderly, immunocompromised individuals. has been known for decades acute lower tract infections which often result hospitalization, while...
Phosphatidylinositol 4,5-biphosphate [PI(4,5)P(2) ], the predominant phosphoinositide (PI) on plasma membrane, binds matrix (MA) protein of human immunodeficiency virus type 1 (HIV-1) and equine infectious anemia (EIAV) with similar affinities in vitro. Interaction PI(4,5)P(2) is critical for HIV-1 assembly membrane. EIAV has been shown to localize internal compartments; hence, significance its interaction unclear. We therefore investigated binding vitro other PIs MA whether intracellular...
: Fluorescence based bioimaging is one of the widely used method for obtaining imperative information on life processes. Objective: Within expansive spectrum fluorescent agents being investigated, trivalent Lanthanide (Ln) ion nanoparticles have attracted attention due to their intrinsic luminescence property. Methods: Here we report a modified sol gel assisted synthesis Europium (Eu) and Samarium (Sm) doped Hydroxyapatite (HAp NPs). Doping Ln ions in selffluorescent hydroxyapatite lattice...
Antibiotics revolutionized the treatment of infectious diseases; however, it is now clear that broad-spectrum antibiotics alter composition and function host's microbiome. The microbiome plays a key role in human health, its perturbation increasingly recognized as contributing to many diseases. Widespread antibiotic use has also resulted emergence multidrug-resistant pathogens, spurring development pathogen-specific strategies such monoclonal antibodies (MAbs) combat bacterial infection. Not...
Restricted replication in the respiratory tract of rhesus monkeys is an intrinsic property bovine parainfluenza virus type 3 (bPIV-3) strains. This host range phenotype bPIV-3 has been utilized as a marker to evaluate attenuation vaccines for human use. Two safety, immunogenicity and efficacy studies primates evaluated compared three (hPIV-3) vaccine candidates: biologically derived bPIV-3, plasmid-derived (r-bPIV-3) chimeric bovine/human PIV-3 (b/hPIV-3). These also examined feasibility...
Klebsiella pneumoniae strains producing extended-spectrum β-lactamases(ESBLs) are a major problem in many different hospitals worldwide,causing outbreaks.
There is an ongoing burden of pneumococcal disease in children despite the use conjugate vaccines (PCVs). This phase 3, open-label, single-arm, multisite, descriptive study was designed to evaluate safety and immunogenicity a 3 + 1 regimen V114 (VAXNEUVANCE™), 15-valent PCV, South Korean infants toddlers. Adverse events (AEs) were reported for 14 d following any vaccination, throughout period serious AEs. Serotype-specific immunoglobulin G (IgG) response rates (proportion participants...
A simple, rapid, single-step microwave-assisted method was developed to prepare CQDs with narrow size distribution using dibasic carboxylic acids as a carbon source. The synthesized were well characterized spectroscopic techniques such P-XRD, FT-IR, high-resolution transmission electron microscopy (HR-TEM), UV-Vis absorption, and photoluminescence spectroscopy. demonstrated excellent photostability, particle in the 1.5–6 nm range. fluorescence quantum yield found be 28%, 7%, 13%, 38%, 31%...
RSV is a common cause of lower respiratory tract infections. Palivizumab, monoclonal antibody (mAb) targeting the fusion (F) protein, only approved agent for prophylaxis, but limited to high-risk infants. MEDI8897, human IgG1 mAb with an extended half-life prefusion conformation F, being developed prevention disease in all infants their first season. To monitor polymorphisms binding regions palivizumab and MEDI8897 F circulating strains, we sequenced isolates collected from OUTSMART...
Healthcare-associated infections (HAI) constitute major health care problem from their frequency, cost and gravity. Fecal carriage of extended-spectrum beta-lactamase (ESBL)-producing isolates has mainly been detected in HAI, few studies have evaluated fecal during non-outbreak situations among patients the community. This study was undertaken to determine spectrum bacterial colonization predisposing risk factors being admitted an acute hospital, Lisboa, with special emphasis on ESBL...