A5079311098- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Surgical Sutures and Adhesives
- T-cell and B-cell Immunology
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Surgical site infection prevention
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 and healthcare impacts
- Acne and Rosacea Treatments and Effects
- Cutaneous lymphoproliferative disorders research
- Nasal Surgery and Airway Studies
- Pressure Ulcer Prevention and Management
- Autoimmune and Inflammatory Disorders Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cytokine Signaling Pathways and Interactions
- Allergic Rhinitis and Sensitization
- History of Medical Practice
- Digital Imaging in Medicine
- LGBTQ Health, Identity, and Policy
- Polyomavirus and related diseases
Thomas Jefferson University
2024-2025
Dermatology Foundation
2024
New York University
2021-2024
Ronald Reagan UCLA Medical Center
2021
University of Pittsburgh Medical Center
2017-2020
University of Pittsburgh
2019-2020
Saint Louis University
2009-2016
University of New Mexico
2013
Fred Hutch Cancer Center
2012
Juntendo University
2012
Primary cutaneous squamous cell carcinoma (cSCC) is responsible for ~10,000 deaths annually in the United States. Stratification of risk poor outcome at initial biopsy would significantly impact clinical decision-making during post operative period where intervention has been shown to be most effective. Using whole-slide images (WSI) from 163 patients 3 institutions, we developed a self supervised deep-learning model predict outcomes cSCC histopathological features diagnosis, and validated...
Abstract Tolerizing mechanisms within the host and tumor microenvironment inhibit T-cell effector functions that can control cancer. These blunt adoptive immunotherapy with infused T-cells due to a complex array of signals determine tolerance, survival, or deletion. Ligation negative regulatory receptors CTLA4, PD-1(PDCD1), LAG3 on normally hinders their response antigen through nonredundant biochemical processes interfere stimulatory pathways. In this study, we used an established mouse...
Abstract Undifferentiated cells have been identified in the prenatal blastocyst, inner cell mass, and gonadal ridges of rodents primates, including humans. After isolation these express molecular immunological markers for embryonic cells, capabilities extended self‐renewal, telomerase activity. When allowed to differentiate, stem phenotypic tissues ectodermal, mesodermal, endodermal origin. implanted vivo, undifferentiated noninduced formed teratomas. In this report we describe a clone...
Coinhibitory receptor blockade is a promising strategy to boost T-cell immunity against variety of human cancers. However, many patients still do not benefit from this treatment, and responders often experience immune-related toxicities. These issues highlight the need for advanced mechanistic understanding improve patient outcomes uncover clinically relevant biomarkers treatment efficacy. T-cell-intrinsic signaling pathways engaged during checkpoint are well defined, particularly...
We used a goat model of contaminated musculoskeletal defect to determine the effectiveness rapidly-resorbing calcium-sulphate pellets containing amikacin reduce local bacterial count. Our findings showed that this treatment eradicated bacteria quickly, performed as well standard polymethylmethacrylate mixed with an antibiotic and had many advantages over latter. The were prepared before surgery absorbed completely. They released all did not require subsequent operation for their removal....
Abstract Despite the continuing advances in treatment of open fractures and musculoskeletal wounds, infection remains a serious complication. Current treatments to prevent utilize surgical debridement irrigation, high doses systemic antimicrobial therapy. The aim this work was evaluate, vitro, potential fast‐resorbing calcium sulfate pellet loaded with an antibiotic. could be used as adjunctive therapy at time irrigation reduce bacterial wound contamination. Small pellets containing binder...
Establishing peripheral CD8+ T cell tolerance is vital to avoid immune mediated destruction of healthy self-tissues. However, it also poses a major impediment tumor immunity since tumors are derived from self-tissue and often induce dysfunction. Thus, understanding the mechanisms that regulate versus has important implications for human health. Signals received tissue environment largely dictate whether responding cells become activated or tolerant. For example, induced expression subsequent...
Few prior studies have examined the potential health risks from transmission of enteric parasites via aquifers contaminated by wastewater onsite systems. A cross-sectional study 600 residents in households served with either systems and private wells or city sewer/water three different sites central New Mexico compared serological responses to Cryptosporidium, a common waterborne infections agent. Study participants completed short self-administered questionnaire questions on demographic...
Background: Strategies to non-invasively detect cutaneous melanoma generally focus on differentiating from non-melanoma lesions. However, given the variabilities in practice and lack of guidelines, it is important for clinicians understand how such strategies technologies perform borderline lesions uncertain clinical behavior. Objective: To evaluate LINC PRAME gene expression presence somatic mutations BRAF, NRAS, and/or TERT severely dysplastic nevi (SDN) assess, combining mutation analyses...
During chronic viral infections, responses by virus-specific CD8+ T cells become marginalized the acquisition of functional defects and reduced cell numbers in a process defined as exhaustion. Similarly, tolerance to self-antigen is also characterized impaired effector function eventual deletion self-reactive cells. Induction both exhaustion involve many shared inhibitory mechanisms, thus similar therapeutic approaches have proven effective these distinct environments. We previously...
Abstract CD8+ T cells must detect foreign antigens and differentiate into effector to eliminate infections. But, when self-antigen is recognized instead, mechanisms of peripheral tolerance prevent acquisition function avoid autoimmunity. These distinct responses are influenced by inflammatory regulatory clues from the tissue environment, but mechanism(s) which naive interpret these signals generate appropriate immune response unclear. The identification molecules operative in cell-fate...
The efficacy of electrical therapy at terminating ventricular fibrillation is highly dependent on the waveform used. We present experimental results which test one theory for defibrillation dependence. Forty-four waveforms (22 monophasic, 22 biphasic) were designed according to theoretical construct Fishier (2000). then tested 67 male guinea pigs (46 21 biphasic waveforms) using a custom defibrillator and 12-mm subcutaneous disc electrodes. There was considerable agreement between results....
Diseases such as sitosterolemias, familial hyperlipidemias, and hypercholesterolemias are characterized by unique dermatological manifestations, including eruptive xanthomas xanthelasmas. Although these conditions relatively rare in dermatology, they hold significant implications for cardiovascular health, potentially leading to fatal outcomes atherosclerotic disease, acute coronary syndrome or hypertensive encephalopathy if untreated. These diseases particularly notable pediatric...
Melanin governs the complex interplay of genetics, environment, and evolution, manifesting in diverse array human skin tones. Produced by melanocytes basal layer epidermis, melanin exists two forms: pheomelanin, yielding yellow red hues, eumelanin, brown black hues. This dynamic interaction subtypes gives rise to rich tapestry colors. While melanin's primary function is protect from UV-induced molecular damage, dysregulation can lead hyperpigmentation, which have profound emotional cosmetic...
Abstract New‐onset psoriasis in patients receiving tumor necrosis factor inhibitors is well recognized children and adults. We describe three who underwent cardiac transplantation developed an analogous form of paradoxic eczema occurring 2‐48 months after starting systemic tacrolimus, a drug widely used topically to treat eczema. Anecdotal reports our experience suggest that tacrolimus taper with alternative antirejection immunosuppressant may lead skin clearance. Pending additional insight,...
BACKGROUND Impaired immunity may drive the increased incidence and aggression of cutaneous squamous cell carcinoma (cSCC) in patients with hematologic malignancy; however, precise mechanisms prognostic biomarkers remain undefined. CD73 maintains elevated immunosuppressive adenosine levels is associated poor prognosis several tumor microenvironments. OBJECTIVE Identify outcome cSCC malignancy. MATERIALS AND METHODS Differentially expressed genes tumors from malignancy experiencing good ( n =...
Context: Approximately 50% of US adults suffer from hypertension, with over 75% inadequately controlled. The baroreceptor reflex elicits vagal stimulation, reducing heart rate and blood pressure. Non-invasive osteopathic cranial manipulation (OCM), including occipito-atlantal (OA) release, may enhance tone. This literature review examines the potential efficacy OCM in optimizing hypertension management by augmenting tone subsequently Objective: To determine whether (OCM) be utilized for...
Providing medically competent care for gender minorities has become a public health focus. Body-gender incongruence, antitransgender biases, and social isolation contribute to lifetime risk of suicide attempts in this population greatly exceeding that the overall US (25%-43% vs 4.6%).1 Gender-affirming hormone therapy (HT) provides several desired physical physiologic changes can reduce suicidal ideation by nearly one half2; however, it also induce unwanted dermatologic side effects.