A5008916380- Platelet Disorders and Treatments
- Venomous Animal Envenomation and Studies
- Cell Adhesion Molecules Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Bone health and treatments
- IgG4-Related and Inflammatory Diseases
- Connective Tissue Growth Factor Research
- Mast cells and histamine
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Biochemical and Structural Characterization
- HER2/EGFR in Cancer Research
- Cardiac Ischemia and Reperfusion
- Neuroendocrine Tumor Research Advances
- Soft tissue tumor case studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- PI3K/AKT/mTOR signaling in cancer
Taipei Medical University
2016-2024
Mackay Medical College
2019-2020
National Taiwan University Hospital
2020
National Cheng Kung University
2018
Fu Jen Catholic University
2018
National Taiwan University
2016-2017
Institute of Medical Sciences
2016
Platelets assume a pivotal role in the pathogenesis of cardiovascular diseases (CVDs), emphasizing their significance disease progression. Consequently, addressing CVDs necessitates targeted approach focused on mitigating platelet activation. Eugenol, predominantly derived from clove oil, is recognized for its antibacterial, anticancer, and anti-inflammatory properties, rendering it valuable medicinal agent. This investigation delves into intricate mechanisms through which eugenol influences...
Life-threatening thrombocytopenia and bleeding, common side effects of clinically available αIIbβ3 antagonists, are associated with the induction ligand-induced integrin conformational changes exposure binding sites (LIBSs). To address this issue, we examined intrinsic mechanisms structure–activity relationships purified disintegrins, from Protobothrops flavoviridis venom (i.e., Trimeresurus flavoviridis), TFV-1 TFV-3 distinctly different pro-hemorrhagic tendencies. a epitope that chimeric...
Polymer polyethylene glycol (PEG), or PEGylation of polypeptides improves protein drug stability by decrease degradation and reduces renal clearance. To produce a pharmaceutical disintegrin derivative, the N-terminal technique was used to modify derivative [KGDRR]trimucrin for favorable safety pharmacokinetic profiles antithrombotic efficacy. We compared intact (RR) PEGylated KGDRR (PEG-RR) in vitro vivo systems their activities. The activity platelet aggregation inhibition bleeding tendency...
Inflammatory myofibroblastic tumor (IMT) is a rare type usually arising in the thoracic or abdominal cavity. Despite its rarity, IMT commonly harbors driver gene rearrangements involving anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1 (ROS1), and neurotrophic tropomyosin-related kinase. We present case of parapharyngeal with convoluted diagnostic test results determining rearrangement. The immunohistochemical stains were ALK-negative ROS1 positive, but result fluorescence situ...
Current alphaIIbbeta3 antagonists are efficacious anti-thrombotics but have significant bleeding risk. The life-threatening thrombocytopenia and bleeding, common side effects of clinically available antagonists, associated with induction ligand-induced integrin conformational changes inhibition inside-out signaling. Emerging evidence suggests that selective outside-in signaling has potent antithrombotic without causing bleeding. To address this issue, we examined whether two purified...