A5048081459- Human Health and Disease
- Digestive system and related health
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Infant Health and Development
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Probiotics and Fermented Foods
- Gastrointestinal motility and disorders
- Medical and Agricultural Research Studies
- Infant Nutrition and Health
- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Birth, Development, and Health
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Healthcare Systems and Public Health
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Child and Adolescent Health
- Allergic Rhinitis and Sensitization
Samara State Medical University
2016-2024
Ministry of Health of the Russian Federation
2019-2024
A group of leading experts in the field pediatric gastroenterology prepared clinical recommendations for diagnosis and treatment functional digestive disorders (FDD) children; they have summarized international domestic experience suggested tactics a pediatrician everyday practice. The first part discusses modern views on disorders, their development mechanisms terminology. article considers biopsychosocial model as well an updated classification based Rome criteria IV, including experience....
A group of experts, leading specialists in the field pediatric gastroenterology have prepared clinical recommendations for diagnosis and treatment functional digestive disorders children; they summarized international domestic experience, suggesting tactics everyday pediatrician's practice. The second part guidelines discusses with abdominal pain: nausea vomiting, dyspepsia, irritable bowel syndrome, pain. authors clarified definitions, classification criteria dyspepsia syndrome taking into...
The article presents an overview of modern Russian and foreign scientific literature, which summarizes data on the value normal intestinal microflora formation, formation microbiocenosis in ontogeny features. causes microbiota lesions their impact child health are described. Relevant effectiveness pre- probiotics prophylaxis noninfectious diseases is given.
Studies over several years have shown an increase in chronic pathology and adverse changes the structure of health groups during schooling. The aim this work is to develop propose a systematization school-related pathology. analysis status Samara schoolchildren allowed establish that first 4 education number healthy children decreases by 18 %, end school there are no more than 11 %. Diseases, frequency which increases with beginning training: diseases musculoskeletal, digestive,...
The article provides an analysis of changes in ideas about pathogenetic mechanisms, approaches to the diagnosis and treatment irritable bowel syndrome children. Current data on pathophysiological mechanisms IBS are presented. Algorithms for management children with this pathology presented, based new positions Rome IV criteria Russian recommendations functional disorders digestive system
The immune system of the body’s mucous membranes plays a huge role in development, maintenance and regulation homeostasis, being an important component multi-component system. structural basis local immunity is lymphatic tissue associated with (MALT). There now scientific evidence that membrane sections different body systems interact closely each other, subject to same regulatory influences. This relationship particularly close between digestive respiratory tract, studies have shown...
The clinical guidelines for the diagnosis and treatment of the3 functional disorders digestive system in children were prepared by a Group Experts, domestic leading specialists field pediatric gastroenterology, who generalized foreign experience, suggesting tactics pediatrician actions everyday practice. Part 3 Guidelines discusses billiard tract dysfunctions constipations. There are no biliary Pediatric Sections Rome Consensus IV; however, Russian school thought has always considered them...
The appearance of new high-tech microbiological research methods has significantly changed the understanding human microbiome. purpose meeting Council Experts "Dysbiosis. immediate and long-term consequences microbiome disorders options for their correction with probiotics" was definition modern positions about possible studying intestinal microbiome, possibilities correcting dysbiosis, use Saccharomyces Boulardii CNCM I-745 to correct in various clinical situations. microbiota large...
The purpose — to comprehensively assess the health status of children and adolescents with chronic diarrhea impact on quality life indicators. Material methods. 466 were examined. main group consisted 240 aged from 1 month 18 years (average age 7.3 ± 5.3 years). comparison 226 groups 1-2 without 6.9 4.6 exclusion criteria newborn period, pathology during decompensation severe somatic pathology. Clinical anamnestic research methods used: parents’ questionnaires, anthropometric measurements,...
The aim of the research: to study structure and epidemiological features chronic diarrhea in children different age periods. Materials methods: data on outpatient cases inpatient care with diseases that are clinically manifested by syndrome were analyzed. A survey 1509 ages was also conducted at an appointment a pediatrician day healthy child, preschool educational institutions city Samara. Results study: as result study, it revealed gastroenterological pathology children, account for 1.8%,...
The urgency of the problem chronic hepatitis C (HCV) is determined by increasing incidence and severe consequences infection in form cirrhosis liver cancer. In Russian Federation, epidemiological situation viral characterized a relatively high mortality associated with C, which determines need to search for contingents it necessary purposefully carry out preventive anti-epidemic measures. aim work conduct comparative analysis Samara region 1997–2021 characterize dynamics changes age...
The literature review substantiates the necessity of diagnosing and forecasting outcomes adverse perinatal exposures. A critical analysis existing approaches was conducted. conjecture is made about diagnostic potential first stool, which a unique source for gathering information intrauterine development fetus. Given that meconium can be non-invasively collected from minutes life, its study particularly valuable identifying risks in ill preterm newborns. authors justify value determining risk...
The growth of protein-energy malnutrition (PEM) in children with prevalence endogenous factors the causes development has not been decreasing Russian Federation and all over world for last decades. This determines relevance multifaceted study this pathology. Consequences PEM suffered early childhood can have a remote character realization influence on human health during whole life. A separate problem is identification mild forms pathology, which are often missed. pathogenesis insufficiently...
Research objective . To analyze the epidemiological features of chronic hepatitis in Russian Federation and Samara region. Materials methods. The data official statistics were analyzed: materials Federal Service for Supervision Field Consumer Protection Human Welfare, Office Welfare Region. Results. long-term dynamics incidence newly diagnosed B region 1999–2021 was synchronous. In 1999–2001 HCV (Chronic B) had maximum values 16,00⁄0000–22,50⁄0000. region, it higher than country. As a result...
The paper presents a review of literature data focused on study levels laboratory inflammatory markers (i. e., lactoferrin, fecal calprotectin, neutrophil gelatinase-associated lipocalin, etc.), as well biomarkers impaired permeability intestinal wall (zonulin, alpha-1-antitrypsin) and epithelial tight junctions occludin) in meconium. An advantage non-invasive diagnostic methods (including tests) used neonatology is emphasized. Availability non-invasiveness meconium test are highlighted....
Ulcerative colitis is recurrent inflammatory disorder of the large intestine characterized by continuous expansion bowel involvement, from rectum to proximal parts. Despite certain similar sign with adults, ulcerative in children has a number special features and distinctions disease course therapy response, therefore such peculiarities should be considered while choosing management strategy. In 2012 European Crohn’s Colitis Organisation Society for Pediatric Gastroenterology, Hepatology...
The aim of this study is to assess the level Toll-like receptor 2 (TLR-2) and thymic stromal lymphopoietin (TSLP) in blood serum children establish relationship between these parameters severity clinical manifestations atopic dermatitis (AD) degree microbial contamination gut. Research materials methods: 68 aged from 3 months 6 years with an AD 31 conditionally healthy corresponding age were examined. Determination TLR-2 TSLP was carried out by enzyme immunoassay, composition intestinal...
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The chronic diarrhea is pretty relevant problem in children due to its incidence, wide range of causes, heterogeneity pathogenetic mechanisms and clinical manifestations. Meantime there no common algorithm for screening such patients with diarrhea. This usually aggravates the diagnosis, timely treatment, finally decreases patient quality life. review provides updated data on etiology, pathogenesis, manifestations diagnostic approaches children. Issues structure management different diseases...
Research objective - at children of the first year life to define pathogenetic metabolism links, significant for development a hypotrophy, with prospect correction revealed violations. 52 deficiency body weight, 30 normal physical are examined. At 65,4% hypotrophy was combined anemia (34,6%), rickets (42,3%), secondary immunological insufficiency (11,5%). Power is connected decrease in content phosphorus, glucose, atsilglitserin, LONP, LVP, activity KFK, ATP level high degrees hypotrophy. I...