A5047460663- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Tissue Engineering and Regenerative Medicine
- Pediatric Urology and Nephrology Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Urinary Bladder and Prostate Research
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Hormonal and reproductive studies
- Spinal Dysraphism and Malformations
- Electrospun Nanofibers in Biomedical Applications
- Enhanced Recovery After Surgery
- Urinary Tract Infections Management
- Cancer Genomics and Diagnostics
- Anesthesia and Sedative Agents
- Sexual Differentiation and Disorders
- Ureteral procedures and complications
- Sexual function and dysfunction studies
- Simulation-Based Education in Healthcare
- Estrogen and related hormone effects
- Cerebrospinal fluid and hydrocephalus
- Hernia repair and management
- Anesthesia and Neurotoxicity Research
- Renal and related cancers
- Hospital Admissions and Outcomes
University of California, Davis
2016-2025
The University of Texas Southwestern Medical Center
2020-2024
Children's Medical Center
2023-2024
Lurie Children's Hospital
2020-2022
Southwestern Medical Center
2020-2022
Changi General Hospital
2021
Chinese University of Hong Kong
2021
Prince of Wales Hospital
2021
Northwestern University
2020-2021
UC Davis Children's Hospital
2016-2018
Abstract To date, there are no efficacious translational solutions for end-stage urinary bladder dysfunction. Current surgical strategies, including diversion and augmentation enterocystoplasty (BAE), utilize autologous intestinal segments (e.g. ileum) to increase capacity protect renal function. Considered the standard of care, BAE is fraught with numerous short- long-term clinical complications. Previous trials employing tissue engineering approaches regeneration have also been unable...
Adenovirus small e1a oncoprotein causes ∼70% reduction in cellular levels of histone H3 lysine 18 acetylation (H3K18ac). It is unclear, however, where this dramatic occurs genome-wide. ChIP-sequencing revealed that by 24 h after expression, erases 95% H3K18ac peaks normal, contact-inhibited fibroblasts and replaces them with one-third as many at new genomic locations. The promoters intergenic regions genes fibroblast-related functions are eliminated infection, established highly induced...
Abstract Complications associated with urinary bladder augmentation provide the motivation to delineate alternative tissue regenerative engineering strategies. We describe results of varying proportion bone marrow (BM) mesenchymal stem cells (MSCs) CD34 + hematopoietic stem/progenitor (HSPCs) co-seeded onto synthetic POC [poly(1,8 octamethylene citrate)] or small intestinal submucosa (SIS) scaffolds and their contribution regeneration. Human BM MSCs HSPCs were SIS at cell ratios 50 K...
Protracted postsurgical inflammation leading to postoperative complications remains a persistent problem in urethral reconstruction. Nanofibers the form of peptide amphiphiles expressing anti-inflammatory peptides (AIF-PA) have positively modulated local inflammatory responses. Urethroplasty is performed repair 5 mm ventral defects with: uncoated small intestinal submucosa (SIS); SIS dip-coated with AIF-PA1 (anti-inflammatory treatment), or AIF-PA6 (control) on 12-week-old male Sprague...