A5058132592- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Urinary Tract Infections Management
- Nitric Oxide and Endothelin Effects
- Ureteral procedures and complications
- Sirtuins and Resveratrol in Medicine
- Polyomavirus and related diseases
- Neonatal Health and Biochemistry
- Kidney Stones and Urolithiasis Treatments
- Redox biology and oxidative stress
- Cardiac, Anesthesia and Surgical Outcomes
- Adolescent and Pediatric Healthcare
- Urinary Bladder and Prostate Research
- Parasites and Host Interactions
- Adenosine and Purinergic Signaling
- Pediatric Pain Management Techniques
- Mitochondrial Function and Pathology
- Prostate Cancer Diagnosis and Treatment
- Testicular diseases and treatments
- Hernia repair and management
- MicroRNA in disease regulation
- Anesthesia and Pain Management
- Helminth infection and control
- Enhanced Recovery After Surgery
- Anatomy and Medical Technology
Children's Hospital of Richmond at VCU
2020-2024
Virginia Commonwealth University
2021-2024
Children's National
2018-2020
Biomedical Research Institute
2018-2019
University of Virginia
2016-2018
Charlottesville Medical Research
2014-2017
University School
2010-2012
Boston University
2008-2012
University Medical Center
2012
Boston Medical Center
2012
Sirtuin-1 (SIRT1) is an NAD(+)-dependent protein deacetylase that sensitive to oxidative signals. Our purpose was determine whether SIRT1 activity the low molecular weight nitrosothiol, S-nitrosoglutathione (GSNO), which can transduce signals into physiological responses. formed mixed disulfides with GSNO-Sepharose, and mass spectrometry identified several cysteines are modified by GSNO, including Cys-67 S-glutathiolated. GSNO had no effect on basal activity, but inhibited stimulation of...
Here we demonstrate a new paradigm in redox signaling, whereby oxidants resulting from metabolic stress directly alter protein palmitoylation by oxidizing reactive cysteine thiolates. In mice fed high-fat, high-sucrose diet and cultured endothelial cells (ECs) treated with high palmitate glucose (HPHG), there was decreased HRas on Cys181/184 (61±24% decrease for cardiac tissue 38±7.0% ECs). This due to oxidation of Cys181/184, detected using matrix-assisted laser desorption/ionization time...
Prenatal hydronephrosis is one of the most common anomalies detected on prenatal ultrasonography. Patients with and ureteral dilation are at increased risk urinary tract infection (UTI) continuous antibiotic prophylaxis (CAP) recommended. However, current guidelines do not define minimum diameter that would be considered a dilated ureter in these patients.We evaluate definition clinically relevant hydroureter, its association UTI, impact CAP.Patients from seven centers were enrolled into...
Introduction Lower urinary tract reconstruction in paediatric urology represents a physiologically stressful event that is associated with high complication rates, including readmissions and emergency room visits. Enhanced recovery after surgery (ERAS) protocol set of multidisciplinary, perioperative strategies designed to expedite surgical without adversely impacting readmission or reoperation rates. Early data demonstrated ERAS reduced complications this population. Methods analysis In...
Ifosfamide and other oxazaphosphorines can result in hemorrhagic cystitis, a constellation of complications caused by acrolein metabolites. We previously showed that single dose IPSE (Interleukin-4-inducing principle from Schistosoma eggs), schistosome-derived host modulatory protein, ameliorate ifosfamide-related cystitis; however, the mechanisms underlying this urotoxicity its prevention are not fully understood. To provide insights into IPSE's protective mechanism, we undertook...
Ageing is an important risk factor for the development of cardiovascular diseases. Vascular ageing mainly characterized by endothelial dysfunction, alteration endothelium-dependent signalling processes and vascular remodelling. The underlying mechanisms comprise increased production reactive oxygen species (ROS), inactivation nitric oxide (.NO) subsequent formation peroxynitrite (ONOO(-)). Elevated ONOO(-) may exhibit new messenger functions post-translational oxidative modification...
Chemotherapy-induced hemorrhagic cystitis is characterized by bladder pain and voiding dysfunction caused hemorrhage inflammation. Novel therapeutic options to treat are needed. We previously reported that systemic administration of the Schistosomiasis hematobium-derived protein H-IPSEH06 (IL-4-inducing principle from Schistosoma mansoni eggs) superior three doses MESNA in alleviating (Mbanefo EC, Le L, Pennington LF, Odegaard JI, Jardetzky TS, Alouffi A, Falcone FH, Hsieh MH. FASEB J 32:...
Introduction Regional techniques are a key component of multimodal analgesia and help decrease opioid use perioperatively, but some may not be suitable for all patients, such as those with spina bifida. We hypothesized peripheral regional catheters would reduce postoperative compared no without increasing pain scores in pediatric patients bifida undergoing major urological surgery. Methods A retrospective review multicenter database established the study enhanced recovery after surgery was...
Ureteroenteric stricture occurs in as many 15% of patients after cystectomy with urinary diversion. First-line management is typically percutaneous nephrostomy (PCN) drainage. We sought to compare costs a urologic approach retrograde stenting through flexible endoscopy and an interventional radiology (IR) PCN antegrade using predictive modeling. The purpose this study inform best practice for initial based on existing literature regardless the benign rate following radical cystectomy. Our...
You have accessJournal of UrologyTechnology & Instruments: Surgical Education Skills Assessment II1 Apr 2014MP14-07 SURGICAL ATTENTION AND MOVEMENT IN NOVICE EXPERT ROBOTIC SURGEONS Rebecca Zee, Sierra J. Seaman, Matthew Engelhard, and Noah S. Schenkman ZeeRebecca Zee More articles by this author , SeamanSierra Seaman EngelhardMatthew Engelhard SchenkmanNoah View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.635AboutPDF ToolsAdd to favoritesDownload CitationsTrack...
You have accessJournal of UrologyPediatrics VII (MP72)1 May 2024MP72-18 THE CONUNDRUM OF HIGH-GRADE HYDRONEPHROSIS WITH INDETERMINATE LASIX RENAL SCAN Elias J. Wehbi, Sarah H. Williamson, Carol A. Davis-Dao, C. D. Anthony Herndon, Joshua Chamberlin, Anne G. Dudley, Shannon Cannon, Gina M. Lockwood, Nora Kern, Rebecca S. Zee, Luis Braga, Valre W. Welch, Kai-Wen Chuang, Melissa McGrath, Heidi Stephany, and Antoine E. Khoury WehbiElias Wehbi , WilliamsonSarah Williamson Davis-DaoCarol Davis-Dao...