A5079388621- Liver physiology and pathology
- Anesthesia and Pain Management
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Scoliosis diagnosis and treatment
- Mechanical Circulatory Support Devices
- Ultrasound in Clinical Applications
- Congenital Heart Disease Studies
- Pain Management and Opioid Use
- Parasitic Infections and Diagnostics
- Pancreatic function and diabetes
- Hernia repair and management
- Vector-Borne Animal Diseases
- Hospital Admissions and Outcomes
- Medical History and Innovations
- Bartonella species infections research
- Herpesvirus Infections and Treatments
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Enhanced Recovery After Surgery
- Public Health Policies and Education
- Urological Disorders and Treatments
Washington University in St. Louis
2019-2022
Children's Hospital & Medical Center
2022
University of Nebraska Medical Center
2022
Texas Children's Hospital
2019-2022
Baylor College of Medicine
2021-2022
St. Louis Children's Hospital
2020-2022
University of Kansas Medical Center
2008-2013
University of Kansas
2009
University of Cincinnati Medical Center
1995-2006
Tulane University
2000
Liver fibrosis is characterized by excessive deposition of extracellular matrix in the liver during chronic injury. During early stages this disease, cells begin to synthesize and secrete profibrotic proteins that stimulate production inhibit degradation. Although it clear these are important for development fibrosis, what remains unknown mechanism which injury stimulates their production. In present study, hypothesis was tested hypoxia-inducible factor-1alpha (HIF-1alpha) activated...
Abstract Background/Aims: During the development of liver fibrosis, mediators are produced that stimulate cells in to differentiate into myofibroblasts and produce collagen. Recent studies demonstrated transcription factor, hypoxia‐inducible factor‐1α (HIF‐1α), is critical for upregulation profibrotic mediators, such as platelet‐derived growth factor‐A (PDGF‐A), PDGF‐B plasminogen activator inhibitor‐1 (PAI‐1) liver, during fibrosis. What remains unknown cell type‐specific regulation these...
Objective Pediatric liver transplantation presents a number of anesthetic challenges, especially in providing adequate perioperative analgesia. In an effort to reduce opioid consumption and improve functional outcomes following pediatric transplantation, we have instituted novel analgesia protocol centered on the provision continuous regional with erector spinae plane (ESP) blockade. Cases We describe preincisional bilateral ESP catheter placement two patients undergoing orthotopic...
To evaluate the clinical effectiveness of bolus-dose fentanyl and midazolam to treat episodic intracranial hypertension in children with severe traumatic brain injury.Retrospective cohort.PICU a university-affiliated children's hospital level I trauma center.Thirty-one 0-18 years age injury (Glasgow Coma Scale score ≤ 8) who received bolus doses and/or for treatment hypertension.None.The area under curve from high-resolution pressure-time plots was calculated represent cumulative exposure:...
Introduction Lower urinary tract reconstruction in paediatric urology represents a physiologically stressful event that is associated with high complication rates, including readmissions and emergency room visits. Enhanced recovery after surgery (ERAS) protocol set of multidisciplinary, perioperative strategies designed to expedite surgical without adversely impacting readmission or reoperation rates. Early data demonstrated ERAS reduced complications this population. Methods analysis In...
OBJECTIVE. The American Academy of Pediatrics recommended routine use varicella vaccine in pediatric practice 1995. We examined the impact immunization on population-based rates varicella-related hospitalizations and emergency department (ED) visits years before after introduction vaccine. STUDY DESIGN. Discharge data for ED encounters from 1990 through 2003 were queried patients <20 age with International Classification Diseases, Ninth Revision, Clinical Modification codes...
Given the complex nature of liver transplant surgery, adult centers typically use a dedicated anesthesia team, which has improved patient outcomes.Our goal was to determine whether pediatric team associated with outcomes.This retrospective cohort study analyzed patients who underwent transplantation from April 2013 September 2020 at St. Louis Children's Hospital. The general group (April 2013-December 2016) compared (January 2017-September 2020). Outcomes measured included cases per...
Liver fibrosis is characterized by increased deposition of collagen in the liver during chronic injury. Previous studies have shown that hypoxia‐inducible factor‐1α (HIF‐1α) a key regulator profibrotic mediator production fibrosis. The study goal was to determine whether HIFs are activated hypoxic hepatocytes and they regulate mediators. Exposure primary mouse vitro either 3% or 1% oxygen (i.e., hypoxia) stimulated nuclear accumulation HIF‐1α HIF‐2α proteins. In addition, hypoxia expression...
Background: Combined practice in pediatric anesthesiology (PA) and critical care medicine (PCCM) was historically common but has declined markedly with time. The reasons for this temporal shift are unclear, existing evidence suggests that length of training is a barrier to contemporary trainees. Among current practitioners, restriction dual-specialty also occurs, unknown at present. We sought describe the demographics population, investigate their perceptions about field, consider factors...
Purpose Posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS) has wide treatment variation resulting in unnecessary resource utilization. Significant pain following this procedure is common and opioid medications are the foundation of postoperative management. Opioid usage difficulties with can impact mobilization, gastric motility, discharge readiness, patient satisfaction. The Perioperative Surgical Home (PSH) model care one method to decrease variability eliminate waste...
Abstract Functional loss of C-C chemokine receptor 7 (CCR7) and its ligands, CCL19 CCL21, has been linked to development autoimmune diseases. Therefore, we hypothesized that CCR7 antagonists could be used promote an immune response measured by tittering antibodies produced in animals injected with test antigens. To this hypothesis C57BL/6 mice on day 0 boosted 20 dinitrophenol (DNP)-Keyhole Limpet Hemocyanin (KLH) a antagonist, 8-83, or the agonist solvent as control. Similar CCR7-/- mouse,...
You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Transitional Urology & GU Congenitalism1 Apr 2018PD48-09 DESIGN AND DEVELOPMENT OF THE PEDIATRIC UROLOGY RECOVERY AFTER SURGERY ENDEAVOR (PURSUE) MULTI-CENTER PILOT EXPLORATORY STUDY Kyle O. Rove, Megan A. Brockel, Amanda F. Saltzman, Brian T. Caldwell, Jacob D. Aubuchon, Douglas E. Coplen, Gino J. Vricella, Timothy P. Welch, Charles W. Concodora, Andrew C. Strine, Rajeev Chaudhry, and Duncan Wilcox RoveKyle Rove More articles...
Purpose Posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS) has wide treatment variation resulting in unnecessary resource utilization. Significant pain following this procedure is common and opioid medications are the foundation of postoperative management. Opioid usage difficulties with can impact mobilization, gastric motility, discharge readiness, patient satisfaction. The Perioperative Surgical Home (PSH) model care one method to decrease variability eliminate waste...