A5062442020- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Ethnobotanical and Medicinal Plants Studies
- Phytochemicals and Antioxidant Activities
- Advances in Cucurbitaceae Research
- Phytochemicals and Medicinal Plants
- Bioactive Compounds and Antitumor Agents
- Autopsy Techniques and Outcomes
- Plasma Applications and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Pharmacological Effects of Natural Compounds
- Glaucoma and retinal disorders
- Neural dynamics and brain function
- Piperaceae Chemical and Biological Studies
- Diet, Metabolism, and Disease
- Medicinal Plants and Neuroprotection
- Plasma Diagnostics and Applications
- AI in cancer detection
- Biochemical Analysis and Sensing Techniques
- Natural Antidiabetic Agents Studies
- Enzyme function and inhibition
- Drug-Induced Hepatotoxicity and Protection
- Laser Design and Applications
- Laser Material Processing Techniques
S.N. Bose National Centre for Basic Sciences
2024
Jadavpur University
2001-2023
College of Medicine & Sagore Dutta Hospital
2021-2023
Medical College and Hospital, Kolkata
2015-2023
Central Council for Research in Homoeopathy
2023
Institute of Bio-Resources and Sustainable Development
2021-2022
University of Kalyani
2022
Ministry of Science and Technology
2022
Government of India
2022
Chinese University of Hong Kong
2019
Background Accurate quantification of cancer hallmark activity is essential for understanding tumor progression, tailoring treatments, and improving patient outcomes. Traditional methods, such as histopathological grading immunohistochemistry protein expression, often overlook the complex interplay between cells microenvironment provide limited insight into hallmark-specific mechanisms. We aimed to develop OncoMark, a high-throughput deep learning-enabled neural multi-task learning framework...
Secondary metabolites from plants provide lead molecules for drug development. Metabolomics is a modern omic-technique comprehensive analysis of phytochemicals. Advances in mass spectrometry (MS) based platforms like GC-MS and LC-MS, helped separation identification several metabolites. Such can be valuable tool identifying potential biomolecules medicinal plants. Despite the use, metabolomics data Indian spices are extremely limited. Similarly, metabolomic studies on Ayurvedic formulations,...
Objective: To prepare and characterize an optimized phospholipid complex of Ursolic acid (UA) to overcome the poor pharmacokinetic properties investigate impact on hepatoprotective activity bioavailability in animal model.Significance: UA is a potential phytoconstituent obtained from several plant sources, which has been explored for its diverse pharmacological activities including hepatoprotection. Its major limitation absorption, rapid elimination, hence low after administration.Methods:...
The consumption of the fruits cucurbitaceae plants is widely popular among Indians due to their various nutritional and medicinal purposes. Some these are well reported in Ayurveda potential therapeutic importance. In particular, this family well-characterized by presence its bitter principle, Cucurbitacin E which differs within species genetic variations. objective study was develop a validated RP-HPLC method for standardization some consumed cucurbits with cucurbitacin as marker compound....
Piper species is one of the most widely consumed spices for culinary purposes. Piperine (PIP) present in has a wide range therapeutic activity including hepatoprotection. However, major biological limitation PIP its low bioavailability after oral administration. Purpose study was to prepare an optimized and adequately characterized PIP–phospholipid complex (PPC) as delivery system overcome these limitations investigate pharmacokinetics hepato-protectivity formulation animal model. Response...
The pathophysiological mechanism(s) driving non-alcoholic fatty liver disease, the most prevalent chronic disease globally, have yet to be fully elucidated. Here, we identify regulator of G protein signaling 6 (RGS6), up-regulated in livers NAFLD patients, as a critical mediator hepatic steatosis, fibrosis, inflammation, and cell death. Human patients with high RGS6 expression exhibited corresponding inflammatory burden, pronounced insulin resistance, poor function. In mice, liver-specific...
Abstract Introduction Luffa acutangula (L.) Roxb, commonly known as ridge gourd (cucurbitaceae), is a common vegetable cultivated in India. It also well‐used medicinal plant Indian traditional medicine. Objectives To analyse the phenolics content of most potent carbonic anhydrase‐inhibiting fraction from an extract L. . Materials and Methods An aqueous ethanol dried fruits was successively fractionated into petroleum ether, dichloromethane ethyl acetate. The subsequent fractions were...
Dose-limiting cardiotoxicity remains a major limitation in the clinical use of cancer chemotherapeutics. Here, we describe role for Regulator G protein Signaling 7 (RGS7) chemotherapy-dependent heart damage, demonstration functional RGS7 outside nervous system and retina. Though expressed at low levels basally, observed robust up-regulation human murine myocardium following chemotherapy exposure. In ventricular cardiomyocytes (VCM), forms complex with Ca 2+ /calmodulin-dependent kinase...
Dose limiting cardiotoxicity remains a major factor in the clinical use of several cancer chemotherapeutics including anthracyclines and antimetabolite 5-fluorouracil (5-FU). Prior work has demonstrated that increase expression R7 family regulator G protein signaling (RGS) protein-binding partner Gβ5, which drives myocyte cytotoxicity. However, though members are expressed heart, exact role each chemotherapy driven heart damage unclear. Here, we demonstrate RGS11, downregulated human...
Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (NAFLD) have yet to be fully delineated and only a single drug, peroxisome proliferator-activated receptor (PPAR) α/γ agonist saroglitazar, has been approved. Here, we sought investigate the role of Regulator G Protein Signaling 7 (RGS7) in hyperlipidemia-dependent hepatic dysfunction. Results: RGS7 is elevated livers NAFLD patients, particularly those with severe damage, pronounced insulin resistance,...
Abstract Off target damage to vital organ systems is an unfortunate side effect of cancer chemotherapy and remains a major limitation the use these essential drugs in clinic. Despite decades research, mechanisms conferring susceptibility driven cardiotoxicity hepatotoxicity remain unclear. In livers patients with history chemotherapy, we observed twofold increase expression G protein regulator RGS7 corresponding decrease fellow R7 family member RGS11. Knockdown via introduction shRNA tail...
Excessive ingestion of the common analgesic acetaminophen (APAP) leads to severe hepatotoxicity. Here we identify G protein β5 (Gβ5), elevated in livers from APAP overdose patients, as a critical regulator cell death pathways and autophagic signaling APAP-exposed liver. Liver-specific knockdown Gβ5 mice protected liver APAP-dependent fibrosis, loss, oxidative stress, inflammation following either acute or chronic administration. Conversely, overexpression was sufficient drive hepatocyte...
Ursolic acid (UA) is a potent plant-based hepatoprotective agent having poor bioavailability, which hampers its therapeutic efficacy. The present study tries to overcome this limitation by combining it with piperine (PIP), proven bioenhancer and agent.The type of interaction (synergism, addition, or antagonism) resulting between UA PIP was analyzed quantified isobologram combination index analysis. activity evaluated measuring the level hepatic marker enzymes. Pharmacokinetic analysis...