A5082840660- Obstructive Sleep Apnea Research
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Muscle activation and electromyography studies
- Genetics and Physical Performance
- Orthopaedic implants and arthroplasty
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Long-Term Effects of COVID-19
- Exercise and Physiological Responses
- Spaceflight effects on biology
- Venous Thromboembolism Diagnosis and Management
- Sports injuries and prevention
- Neuroscience of respiration and sleep
- Knee injuries and reconstruction techniques
- Cephalopods and Marine Biology
- Extracellular vesicles in disease
- Cellular Mechanics and Interactions
- Patient Safety and Medication Errors
- RNA Research and Splicing
- Nutrition and Health in Aging
- Hemodynamic Monitoring and Therapy
- Cardiovascular and Diving-Related Complications
- Dietary Effects on Health
- Diagnosis and Treatment of Venous Diseases
University of Florida
2022-2024
University of Massachusetts Amherst
2020-2024
Washington University in St. Louis
2022-2023
University of Toledo
2017-2020
James Madison University
2016-2018
Hospital Universitario de Móstoles
2018
Fundación Renal
2018
Hôpital Cardiologique du Haut-Lévêque
2017
University of Nebraska Medical Center
2012
Université Clermont Auvergne
2005
In this investigation, we addressed the contribution of core circadian clock factor, BMAL1, in skeletal muscle to both acute transcriptional responses exercise and remodeling response training. Additionally, adopted a systems biology approach investigate how loss BMAL1 altered peripheral tissue homeostasis as well training adaptations iWAT, liver, heart, lung male mice.
Gender-related differences in maximal leg muscle power were examined 496 females and 426 males aged 8 to 20 years. Cycling peak (CPP, including the force required accelerate flywheel of cycle ergometer) was measured during three sprints. Optimal velocity (Vopt, at CPP) also determined. No gender-differences observed anthropometric characteristics cycling performance between 8- 14-year-old. From age 14, however, showed a higher CPP than females, but lean volume (LLV, assessed by...
Circadian rhythms drive our daily behaviors to coincide with the earth’s rotation on an approximate 24-h cycle. The circadian clock mechanism present in nearly every cell is responsible for and comprised of a transcriptional-translational feedback loop mammals. central resides hypothalamus responding external light cues, whereas peripheral clocks receive signals from are also sensitive cues feeding activity. Of clocks, skeletal muscle particularly exercise which has shown be important...
The overall objective of the study was to identify mechanisms through which intercellular adhesion molecule-1 (ICAM-1) augments adhesive and fusogenic properties myogenic cells. Hypotheses were tested using cultured myoblasts fibroblasts, do not constitutively express ICAM-1, fibroblasts forced full length ICAM-1 or a truncated form lacking cytoplasmic domain ICAM-1. mediated myoblast fusion quantified novel assays cell mixing experiments. We report that myotubes homophilic...
Chronic lung disease is often accompanied by disabling extrapulmonary symptoms, notably skeletal muscle dysfunction and atrophy. Moreover, the severity of respiratory symptoms correlates with decreased mass in turn lowered physical activity survival rates. Previous models atrophy chronic modeled obstructive pulmonary (COPD) relied on cigarette smoke exposure LPS stimulation, but these conditions independently affect even without accompanying disease. there an emerging pressing need to...
The purpose of this study was to evaluate the influence knee joint range motion (RoM) on torque–velocity relationship and fatigue in extensor muscles 7 young (median = 26 y) older (68 adults. Each leg assigned a RoM (35° or 75°) over which perform protocol (maximal isokinetic contractions, 60–300°·s −1 ) (120 maximal contractions at 120°·s , 0.5 Hz). Six participants were unable reach 300°·s 35°. Therefore, velocity eliciting 75% peak torque 60°·s ( V 75 °·s calculated for each from fit...
Abstract Exercise is firmly established as a key contributor to overall well-being and frequently employed therapeutic approach mitigate various health conditions. One pivotal aspect of the impact exercise lies in systemic transcriptional response, which underpins its beneficial adaptations. While extensive research has been devoted understanding response exercise, our knowledge protein constituents nuclear processes that accompany gene expression skeletal muscle remains largely elusive. We...
Chronic lung disease is often accompanied by disabling extrapulmonary symptoms, notably skeletal muscle dysfunction and atrophy. Moreover, the severity of respiratory symptoms correlates with decreased mass in turn lowered physical activity survival rates. Previous models atrophy chronic modeled COPD relied on cigarette smoke exposure LPS-stimulation, but these conditions independently affect even without accompanying disease. there an emerging pressing need to understand manifestations...
Obstructive sleep apnea (OSA) is a disorder that results daytime sleepiness and fatigue. Additionally, OSA increases the risk for cardiovascular disease diabetes, which exacerbated by sedentary behavior. Obesity are frequent co-morbid conditions, so impact of OSA, independent obesity, on physical activity (PA) not clear. PURPOSE: To examine effect objectively measured PA via accelerometer. METHODS: Overweight-to-obese individuals were recruited screened presence portable diagnostic device...
The energetic cost of generating force is greater than maintaining it. Additionally, dynamic contractions are more energetically costly isometric contractions. Metabolic economy (ME; mass-normalized torque or power produced per unit ATP consumed) similar between young and older adults during contractions, but less known about age-related differences in ME PURPOSE: To examine maximal effort isometric, isokinetic, isotonic the knee extensor muscles. We hypothesized that would be present only...
Obstructive Sleep Apnea (OSA) is a disorder characterized by repetitive partial and/or complete airway collapse of the upper airway. This significantly increases risk for Cardiovascular Disease (CVD) and heart failure. The respiratory effort against closed has been shown to result altered hemodynamic variables, suggesting cardiovascular remodeling. To date, these findings have only at rest. Whether alterations manifest during exercise not examined. PURPOSE: determine effect that OSA on...
Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder in which obesity risk factor. Despite this relationship, OSA increases the for developing diabetes mellitus (DM) independent of total body adiposity. The mechanisms linking and DM are complex not well understood. Visceral fat well-established factor due to its increased metabolic properties, may be contributing link between DM. PURPOSE: To examine differences visceral vs. non-OSA controls. METHODS: Ten 21 control subjects were...
In this investigation, we addressed the contribution of core circadian clock factor, BMAL1, in skeletal muscle to both acute transcriptional responses exercise and remodelling response training. Additionally, adopted a systems biology approach investigate how loss BMAL1 altered peripheral tissue homeostasis as well training adaptations iWAT, liver, heart, lung male mice.
Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder affecting 2 – 4% of the middle-aged population. Individuals with OSA have an altered hemostatic balance favoring coagulation that may predispose them to cardiovascular disease and/or myocardial events. Although resting well understood, exercise response less described. PURPOSE: To determine after acute aerobic in Apnea. METHODS: Eighteen males (nine vs. nine Controls) aged 41 + 13 yrs. and 28.4 3.5 BMI were recruited from university...
The purpose of the study was to identify mechanisms through which intercellular adhesion molecule‐1 (ICAM‐1) augments adhesive and fusogenic properties myoblasts. Immuno‐precipitation myoblast assays using recombinant ICAM‐1, as well cell mixing experiments ICAM‐1+ control myoblasts, demonstrated that homophilic trans‐interactions for ICAM‐1 serve a mechanism myoblast‐myoblast adhesion. Homophilic were found trigger fusion signaling function cytoplasmic domain GTPase Rac activity,...
We previously demonstrated that intracellular adhesion molecule‐1 (ICAM‐1) expression by satellite cells/myoblasts contributes to muscle regeneration in vivo and augments myogenesis vitro. Recently, we forced of ICAM‐1 cultured myoblasts enhances myoblast‐myoblast through homophilic trans ‐interactions. The primary purpose this study was determine if ‐interactions for myoblast fusion myotubes. A secondary ICAM‐1‐ICAM‐1 interactions augment the myogenic conversion fibroblasts. Hypotheses were...
etc. Thus we conducted this study to evaluate the effect of FIR on ABI in HD patients with PAD.METHODS: We enrolled 198 maintenance study.PAD was defined as ≤ 0.90.Only PAD received WS TY101 emitter (Firapy) for 40 minutes during each session, three times weekly six months.The measured bilateral lower extremities 4 [pre-dialytic timing (0 minute) and after initiation session at both day 0 6 months therapy].RESULTS: Fifty-one out had PAD.In comparison period without therapy 51 patients,...