Cristián Dotto

ORCID: 0000-0002-5898-0190
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About
Contact & Profiles
Research Areas
  • Antimicrobial Resistance in Staphylococcus
  • Antibiotic Resistance in Bacteria
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Bacterial biofilms and quorum sensing
  • Environmental and Cultural Studies in Latin America and Beyond
  • Water Resource Management and Quality
  • Genomics and Phylogenetic Studies
  • Infective Endocarditis Diagnosis and Management
  • Mycobacterium research and diagnosis
  • Nanoplatforms for cancer theranostics
  • Biochemical and Structural Characterization
  • bioluminescence and chemiluminescence research
  • Photodynamic Therapy Research Studies
  • Evolution and Genetic Dynamics

Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2022

University of Buenos Aires
2012-2021

Experimental Medicine and Biology Institute
2021

Institute of Astronomy and Space Physics
2016

Salicylic acid (SAL) has recently been shown to induce biofilm formation in Staphylococcus aureus and affect the expression of virulence factors. This study was aimed investigate effect SAL on regulatory agr system its impact S. formation. The quorum-sensing system, which is a central regulator pathogenicity, plays pivotal role dispersal mature biofilms contributes creation new colonization sites. Here, we demonstrate that impairs by interfering with expression. As revealed our work,...

10.1038/s41598-021-82308-y article EN cc-by Scientific Reports 2021-02-03

Aspirin has provided clear benefits to human health. But salicylic acid (SAL) -the main aspirin biometabolite- exerts several effects on eukaryote and prokaryote cells. SAL can affect, for instance, the expression of Staphylococcus aureus virulence factors. also form complexes with iron cations it been shown that different chelating molecules diminished formation S. biofilm. The aim this study was elucidate whether content limitation caused by modify metabolism and/or metabolic regulators...

10.3389/fmicb.2017.00004 article EN cc-by Frontiers in Microbiology 2017-01-23

Staphylococcus aureus nasal carriage is a risk factor for individuals suffering from trauma, surgical procedures, invasive devices, and/or decreased immunity. Recently, we demonstrated that artificial colonization with an attenuated S. mutant reduced by bacterial interference the of pathogenic strains . This could be optional tool to diminish rate infections in hospitalized patients. The aim this study was construct safe Δ aroA and discriminate it colonizing osteomyelitis isolates Sma I...

10.1155/2012/468539 article EN cc-by International Journal of Microbiology 2012-01-01

<p class="western" lang="es-ES" align="justify"><span style="font-size: medium;"><span small;">La presencia de nitratos en las fuentes agua subterránea es común la Provincia Buenos Aires. Puede atribuirse a labores agrícola-ganaderas o al mal diseño funcionamiento los sistemas sépticos. La dicho ion perjudicial para salud, por lo que su concentración máxima potable está regulada. desnitrificación biológica, llevada cabo forma </span><span...

10.22201/iingen.0718378xe.2022.15.2.79124 article ES Revista AIDIS de Ingeniería y Ciencias Ambientales Investigación desarrollo y práctica 2022-08-06

ABSTRACT Acinetobacter baumannii is a human pathogen that frequently acquires antibiotic resistance genes leading to the emergence of multi-drug-resistant (MDR) strains. To investigate role transformation in acquisition determinants by this species, susceptible strain A118 was exposed genomic DNA carbapenem-resistant Klebsiella pneumoniae (CRKp). Resistant transformants were obtained and an increase level all β-lactam antibiotics observed. Whole genome analysis transformant clones...

10.1101/308833 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2018-04-26
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