A5046335803- Archaeology and ancient environmental studies
- Pleistocene-Era Hominins and Archaeology
- Archaeology and Natural History
- Viral Infections and Vectors
- Bat Biology and Ecology Studies
- Archaeology and Rock Art Studies
- Virology and Viral Diseases
- Geology and Paleoclimatology Research
- Botany, Ecology, and Taxonomy Studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Rabies epidemiology and control
- Plant Pathogens and Fungal Diseases
- Animal Genetics and Reproduction
- Rangeland and Wildlife Management
- Wildlife Ecology and Conservation
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Soil and Water Nutrient Dynamics
- Animal Virus Infections Studies
- Forensic Anthropology and Bioarchaeology Studies
- Viral Infections and Outbreaks Research
- Pluripotent Stem Cells Research
- SARS-CoV-2 and COVID-19 Research
- Constructed Wetlands for Wastewater Treatment
- Vector-Borne Animal Diseases
Department of Primary Industries
2015-2024
Film Independent
2020
Washington University in St. Louis
2008-2018
Department of Agriculture, Fisheries and Forestry
2013-2017
The University of Queensland
2016-2017
AgResearch
2006-2014
The University of Notre Dame Australia
2014
Crown Research Institutes
2011
Scripps Research Institute
2001
Texas A&M University
2001
Bats of the genus Pteropus have been identified as reservoir hosts for henipaviruses Hendra virus (HeV) and Nipah (NiV). The aim these studies was to assess likely mechanisms transmission from bats. In a series experiments, bats Malaysia Australia were inoculated with NiV HeV, respectively, by natural routes infection. Despite an intensive sampling strategy, no recovered Malaysian HeV reisolated only one Australian bat; disease seen. These experiments suggest that opportunities henipavirus...
Myocardial infarction and ischemic heart disease are the leading cause of death in industrial world. Therapies employed for treating these diseases aimed at promoting increased blood flow to cardiac tissue. Pharmacological induction new coronary growth has recently been explored, however, clinical trials with known proangiogenic factors have disappointing. To identify novel therapeutic targets, we explored signaling pathways that govern embryonic development. Using a combination genetically...
Transthyretin (TTR) is a soluble human plasma protein that can be converted into amyloid by acid-mediated dissociation of the homotetramer monomers. The pH required for disassembly also results in tertiary structural changes within monomeric subunits. To understand whether these are amyloidogenicity, we created Phe87Met/Leu110Met TTR variant (M-TTR) according to analytical ultracentrifugation and gel filtration analyses nonamyloidogenic at neutral pH. Results from far- near-UV circular...
Summary 1. The management of migratory species is challenging because insufficient data on long‐range movement patterns, habitat use, and the impact anthropogenic pressures (e.g. hunting) throughout their home ranges. 2. We evaluate current abundance mobility Malayan flying fox Pteropus vampyrus , a threatened fruit bat ecological economic significance across Southeast Asia, using roost site surveys satellite telemetry. combined this with from hunter license sales population projection...
The uptake of phosphorus, the biomass, and standing P stock were measured over course a year in roots shoots Eurasian watermilfoil, Myriophyllum spicatum, from Lake Wingra, Wisconsin. resulting data used to estimate relative contributions root shoot phosphorus economy plant examine role moving between sediment water. total yearly by square meter was 3.0 g m −2 . Root accounted for 2.2 g, only 0.8 g. rate release healthy insignificant, but about 2.8 yr −1 lost due turnover. Since most is much...
Hendra virus (HeV) causes highly lethal disease in horses and humans the eastern Australian states of Queensland (QLD) New South Wales (NSW), with multiple equine cases now reported on an annual basis. Infection excretion dynamics pteropid bats (flying-foxes), recognised natural reservoir, are incompletely understood. We sought to identify key spatial temporal factors associated flying-foxes over a 2300 km latitudinal gradient from northern QLD southern NSW which encompassed all known case...
Fibroblast Growth Factor (FGF) signaling is important for skeletal development; however, cell-specific functions, redundancy, and feedback mechanisms regulating bone growth are poorly understood. FGF receptors 1 2 (Fgfr1 Fgfr2) both expressed in the osteoprogenitor lineage. Double conditional knockout mice (DCKO) mice, which were inactivated using an osteoprogenitor-specific Cre driver, appeared normal at birth; DCKO showed severe postnatal defects that include ∼50% reduction body weight...
Abstract Background Effective conservation management of highly mobile species depends upon detailed knowledge movements individuals across their range; yet, data are rarely available at appropriate spatiotemporal scales. Flying-foxes ( Pteropus spp.) large bats that forage by night on floral resources and rest day in arboreal roosts may contain colonies many thousands individuals. They the largest mammals capable powered flight, mobile, which makes them key seed pollen dispersers forest...
Following the SARS outbreak, extensive surveillance was undertaken globally to detect and identify coronavirus diversity in bats. This study sought prevalence of coronaviruses bats Australasian region. We identified four different genotypes coronavirus, three which (an alphacoronavirus two betacoronaviruses) are potentially new species, having less than 90% nucleotide sequence identity with most closely related described viruses. did not any SARS-like betacoronaviruses, despite targeting...
Bats of the genus Pteropus (flying-foxes) are natural host Hendra virus (HeV) which periodically causes fatal disease in horses and humans Australia. The increased urban presence flying-foxes often provokes negative community sentiments because reduced social amenity concerns HeV exposure risk, has resulted calls for dispersal flying-fox roosts. However, it been hypothesised that disturbance roosts may result a stress-mediated increase infection flying-foxes, an spillover risk. We sought to...
White spot disease, caused by infection with white syndrome virus (WSSV), is a serious panzootic affecting prawn aquaculture. The disease has spread rapidly around the prawn-culturing regions of world through number previously identified mechanisms. ability to distinguish and trace strains WSSV great benefit identify, then limit, translocation routes disease. Here, we describe novel genotyping method using 34 short tandem repeat viral genome concurrently. This technique highly sensitive...
Pteropid bats (flying-foxes) are the natural reservoir of Hendra virus, an emergent paramyxovirus responsible for fatal infection in horses and humans Australia. Pteropus alecto (the Black flying-fox) paraphyletic P. conspicillatus Spectacled appear to be primary hosts. Previous studies have suggested that physiological ecological factors may underpin dynamics flying-foxes, subsequent spillover turn humans. We sought examine temporal trends urinary cortisol concentration wild Australian...
Background Understanding the long-distance movement of bats has direct relevance to studies population dynamics, ecology, disease emergence, and conservation. Methodology/Principal Findings We developed trialed several collar platform terminal transmitter (PTT) combinations on both free-living captive fruit (Family Pteropodidae: Genus Pteropus). examined weight, size, profile comfort as key determinants maximized activity. then tested importance bat-related variables (species size/weight,...
Abstract The African penguin population has declined precipitously in recent decades, and if current rates of decline persist, this species could become extinct the wild by 2035. Resource extraction small pelagic fish prey purse-seine fishery around breeding colonies been identified as a demographically meaningful threat to penguins. Consequently, long-term, effective no-take zones have endorsed an expert panel scientists constituted South government. Here, we consider six largest that...
To fully understand prehistoric land use patterns, we must define how peoples used particular places on the landscape over longer periods of time. Factors influencing multi-year include human modifications to as a result previous occupations. The construction relatively elaborate and costly facilities for anticipated reuse is one type modification associated with repeated occupation specific locations. Slab-lined cylindrical basins southwest Wyoming are an example that facility....
VEGF signaling through its tyrosine kinase receptor, VEGFR2 (FLK1), is critical for tumor angiogenesis. Previous studies have identified a gene dosage effect of VegfA in embryonic development and vessel homeostasis, neovascularization, growth, potent inhibitors been used to treat variety cancers. Inhibition FGFR has also considered as an antiangiogenic approach with neutralizing antibodies or pharmacological the VEGFR domain at least short-term efficacy some cancers; however, affects leading...
There is no unified place where genomics researchers can search through all available raw genomic data in a way similar to OMIM for genes or Uniprot proteins. With the recent increase amount of that being produced and ever-growing promises precision medicine, this becoming more problem. DNAdigest charity working promote efficient sharing human improve outcome research diagnostics benefit patients. Repositive, social enterprise spin-out DNAdigest, building an online platform indexes stored...
Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified multiple types of human cancer and congenital birth defects. In lung cancer, 9 (FGF9), a high-affinity ligand for FGFR3, is overexpressed 10% primary resected non-small cell (NSCLC) specimens. Furthermore, mouse model where FGF9 can be induced epithelial cells, proliferation ensuing tumorigenesis dependent on FGFR3. To develop new customized therapies cancers that are FGFR3 activation, we used this to...