A5073831561- Metabolomics and Mass Spectrometry Studies
- Cultural Heritage Materials Analysis
- Forensic and Genetic Research
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Forensic Toxicology and Drug Analysis
- Nutritional Studies and Diet
- Forensic Fingerprint Detection Methods
- Animal Nutrition and Physiology
- Phytoestrogen effects and research
- Cancer-related gene regulation
- Trace Elements in Health
- Diverticular Disease and Complications
- Gene expression and cancer classification
- Inflammatory mediators and NSAID effects
- Colorectal and Anal Carcinomas
- Gut microbiota and health
- Physiological and biochemical adaptations
- Heterotopic Ossification and Related Conditions
- Adipose Tissue and Metabolism
- Colorectal Cancer Screening and Detection
- Pharmacogenetics and Drug Metabolism
- Stoma care and complications
- Pharmacological Effects and Assays
Aarhus University
1959-2025
St. Antonius Ziekenhuis
2023
Westfriesgasthuis
2019
Aarhus University Hospital
2014
Abstract Untargeted metabolomics is the study of all detectable small molecules, and in geroscience, has shown great potential to describe biological age—a complex trait impacted by many factors. Unfortunately, sample sizes are often insufficient achieve sufficient power minimize biases caused by, for example, demographic In this study, we present analysis age ~10,000 toxicologic routine blood measurements. The untargeted screening samples obtained from ultra‐high pressure liquid...
Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability anatomically and functionally repair the after an injury that mimics human myocardial infarction. In humans, such leads permanent scarring. Cardiac has been linked metabolism oxygenation state, but so far, these factors remain be detailed in model. this descriptive study, we have investigated metabolic changes occurred during cardiac axolotl. Results We describe systemic local involving...
The illicit drug 3,4-methylenedioxymethamphetamine (MDMA) has profound physiological cerebral, cardiac, and hepatic effects that are reflected in the blood. Screening of blood for MDMA other narcotics routinely performed forensics analysis using ultra-performance liquid chromatography with high-resolution time-of-flight mass spectrometry (UPLC–HR-TOFMS). aim this study was to investigate whether such UPLC–HR-TOFMS data collected over a two-year period could be used untargeted metabolomics...
The relationship between in vitro and vivo starch digestion kinetics was studied portal vein catheterised pigs fed breads varying dietary fibre (DF) content composition. were a low DF white wheat bread, two high whole grain rye without with kernels experimental added arabinoxylan or oat β-glucan concentrates, respectively. In vitro, samples collected at 0, 5, 10, 15, 30, 60, 120 180 min the cumulative hydrolysis curve for modelled, whereas absorption models based on taken every 15 up to 60...
Increased dietary fiber (DF) fermentation and short-chain fatty acid (SCFA) production may stimulate peptide tyrosine-tyrosine (PYY) secretion. In this study, the effects of hindgut SCFA on postprandial PYY plasma levels were assessed using different experimental diets in a porto-arterial catheterized pig model. The pigs fed varying source DF for one week 3×3 Latin square designs. sources whole-wheat grain, wheat aleurone, rye aleurone-rich flour, flakes, resistant starch. Postprandial blood...
Fingermarks are frequently collected at crime scenes by using gelatin lifters for preservation and transport of the marks to a forensic laboratory inspection. The preserve both imprint fingermark pattern necessary identification purposes chemical residue mark potentially useful profiling person who left fingermark. patterns traditionally recorded photography/optical imaging, but methods analysis residues on scarce. Here we report first method fingermarks desorption electrospray ionization...
How species thrive in a wide range of environments is major focus evolutionary biology. For many species, limited genetic diversity or gene flow among habitats means that phenotypic plasticity must play an important role their capacity to tolerate environmental heterogeneity and colonize new habitats. However, we have understanding the molecular components govern ecologically relevant phenotypes. We examined this hypothesis spider (Stegodyphus dumicola) with extremely low species-wide...
Despite the advent of DNA profiling, fingerprints still play an important role in suspect identification. However, if single crime scene marks may be challenging to identify, overlapping fingermarks, understandably, pose even greater challenge. In last decade, mass spectrometry-imaging methods have provided a possible solution separation fingermarks from two or more donors, based on differential chemical composition. there are no studies attempting separate same donor. This is relation...
The metabolomics field is under rapid development. In particular, biomarker identification and pathway analysis are growing, as untargeted usable for discovery research. Frequently, new processing statistical strategies proposed to accommodate the increasing demand robust standardized data. One such algorithm XCMS, which processes raw data into integrated peaks. Multiple studies have tried assess effect of optimizing XCMS parameters, but it challenging quantify quality output. this study, we...
Loss-of-function mutations in the transmembrane ABCC6 transport protein cause pseudoxanthoma elasticum (PXE), an ectopic, metabolic mineralization disorder that affects skin, eye, and vessels. is assumed to mediate efflux of one or several small molecule compounds from liver cytosol circulation. Untargeted metabolomics using liquid chromatography-mass spectrometry was employed inspect cytosolic extracts mice with targeted disruption Abcc6 gene. Absence induced altered profile metabolites...
GHB is an endogenous short-chain organic acid presumably also widely applied as a rape and knock out drug in cases of drug-facilitated crimes or sexual assaults (DFSA). Due to the nature its fast metabolism vivo, detection window exogenous however narrow, making it challenging prove use DFSA cases. Alternative markers intake have recently appeared though none has hitherto been validated for forensic use. UHPLC-HRMS based screening blood samples drugs abuse routinely performed several...
Inflammatory markers such as serum C-reactive protein (CRP) are used routine to detect anastomotic leakage following colorectal surgery. However, CRP is characterized by a relatively low predictive value, emphasizing the need for development of novel diagnostic approaches. Volatile organic compounds (VOCs) gaseous metabolic products deriving from all conceivable bodily excrements and reflect (alterations in) patient's physical status. Therefore, VOCs increasingly considered potential...
<title>Abstract</title> Biomarker discovery for degenerative diseases is challenging due to low statistical power, selection bias, and biological variability. To address these problems, we introduced pre-diagnostic longitudinal sampling using samples from the Danish Blood Donor Study. We obtained up six metabolomics profiles one-year intervals with latest profile within one year before osteoporosis diagnosis, including 99 cases controls. matched patients controls based on sex, age, site,...
Colorectal cancer causes the majority of large bowel obstructions and surgical resection remains gold standard for curative treatment. There is evidence that a deviating stoma as bridge to surgery can reduce postoperative mortality rate; however, optimal type unclear. The aim this study was compare outcomes between ileostomy colostomy in left-sided obstructive colon cancer.This national, retrospective population-based cohort with 75 contributing hospitals. Patients radiological 2009 2016,...
Abstract A liquid chromatography–MS (LC-MS) metabolomics analysis of plasma from portal–arterial catheterised pigs fed breads prepared with whole-grain rye or wheat flour added concentrated arabinoxylan (AX) β-glucan (BG) was conducted. Comparison the effects fibres whole grains has received little attention. Six female were given two white AX oat BG, ground (GR) intact kernels (RK), and a control bread (WF) on separate occasions in randomised cross-over design. The amount available...
Abstract Changes in pharmacokinetics and endogenous metabolites may underlie additive biological effects of concomitant use antipsychotics opioids. In this study, we employed untargeted metabolomics analysis targeted to examine the changes drug prefrontal cortex (PFC), midbrain, blood rats following acute co-administration quetiapine methadone. Rats were divided into four groups received cumulative increasing doses (QTP), methadone (MTD), + (QTP MTD), or vehicle (control). All samples...