Douglas R. Danforth

ORCID: 0000-0002-6029-4210
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Ovarian function and disorders
  • Reproductive Biology and Fertility
  • Hypothalamic control of reproductive hormones
  • Simulation-Based Education in Healthcare
  • Growth Hormone and Insulin-like Growth Factors
  • Reproductive Physiology in Livestock
  • Reproductive System and Pregnancy
  • Innovations in Medical Education
  • Endometriosis Research and Treatment
  • Topic Modeling
  • Natural Language Processing Techniques
  • Disaster Response and Management
  • Estrogen and related hormone effects
  • Sperm and Testicular Function
  • Cardiac Arrest and Resuscitation
  • Angiogenesis and VEGF in Cancer
  • TGF-β signaling in diseases
  • Speech and dialogue systems
  • Menstrual Health and Disorders
  • Effects and risks of endocrine disrupting chemicals
  • Sexual Differentiation and Disorders
  • Clinical Reasoning and Diagnostic Skills
  • Virtual Reality Applications and Impacts
  • Chemical Synthesis and Analysis
  • Phytoestrogen effects and research

The Ohio State University
2011-2024

The Ohio State University Wexner Medical Center
2015-2022

Bridge University
2016

Northwestern University
2011

Institute of Animal Reproduction and Food Research
2002

Polish Academy of Sciences
2002

Ohio State University Hospital
1998

Weatherford College
1998

University of California, San Diego
1995

Eastern Virginia Medical School
1986-1994

Progesterone and 17 alpha-hydroxyprogesterone (but not other steroids such as testosterone, corticosterone, beta-estradiol, estrone, dehydroepiandrosterone, 20 alpha-hydroxypregnen-3-one, androstenedione, pregnenolone) were shown to cause an immediate increase, in free cytosolic calcium ([Ca2+]i) both capacitated noncapacitated human sperm, using the fluorescent indicator fura 2. Significant increases [Ca2+]i observed with 10 ng/ml progesterone, while maximum effects seen 1 microgram/ml...

10.1016/s0021-9258(19)40024-0 article EN cc-by Journal of Biological Chemistry 1990-01-01

Abstract Immersive learning environments that use virtual simulation ( VS ) technology are increasingly relevant as medical learners train in an environment of restricted clinical training hours and a heightened focus on patient safety. We conducted consensus process with breakout group the 2017 Academic Emergency Medicine Consensus Conference “Catalyzing System Change Through Health Care Simulation: Systems, Competency, Outcomes.” This examined current uses assessment, including limitations...

10.1111/acem.13308 article EN Academic Emergency Medicine 2017-09-09

We studied 71 women with the clinical diagnosis of acute pelvic inflammatory disease (PID) by laparoscopy and comprehensive microbiology in order to define major etiologic determinants poor fertility prognosis after tubal infection. Fifty were found have PID. Of 50 women, 23 pregnancy seeking had a subsequent evaluation determine outcome. Seven 13 non-gonococcal infection an adverse reproductive outcome, compared none 10 gonococcal (P = .007). Two groups causes for outcome found. seven...

10.1093/infdis/158.3.510 article EN The Journal of Infectious Diseases 1988-09-01

Although traditional virtual patient simulations are designed to teach and assess clinical reasoning skills, few employ conversational dialogue with the patients. The standardized patients (VSPs) described herein represent that students interview using natural language. Students take histories develop differential diagnoses of VSPs as much they would or actual student-VSP interactions recorded, creating a comprehensive record questions order in which were asked, can be analyzed...

10.1097/sih.0000000000000195 article EN Simulation in Healthcare The Journal of the Society for Simulation in Healthcare 2016-12-07

Abstract As mass casualty incidents continue to escalate in the United States, we must improve frontline responder performance increase odds of victim survival. In this article, describe First Responder Virtual Reality Simulator, a high‐fidelity, fully immersive, automated, programmable virtual reality (VR) simulation designed train responders treat and triage victims incidents. trainees don wireless VR head‐mounted display linked compatible desktop computer. Trainees see hear autonomous,...

10.1002/emp2.12903 article EN cc-by-nc-nd Journal of the American College of Emergency Physicians Open 2023-02-01

The regulation of preantral follicle growth in mammals is poorly understood. availability an adequate vascular supply to provide endocrine and paracrine signals may be important during the early states as well later selection dominance. objective present study was investigate whether endothelial factor (VEGF) plays a role follicular development rat ovary. Immature (age, 21 days) Sprague-Dawley rats were injected with 500 ng VEGF saline or 50 μg diethylstilbestrol (DES) oil under bursa one...

10.1095/biolreprod.101.000679 article EN Biology of Reproduction 2003-05-01

Virtual Worlds such as Second Life provide unique opportunities to simulate real life scenarios and immerse the user in an environment that can be tailored meet specific educational requirements. In these Immersive Learning Environments, students faculty interact from anywhere world. From a general education perspective, they allow for virtual classrooms, libraries, interactive role-playing, remote seminars, etc. medical science Environments used model doctor-patient interaction, clinical...

10.4101/jvwr.v2i2.707 article EN Journal of Virtual Worlds Research 2009-07-19

ACADEMIC EMERGENCY MEDICINE 2011; 18:559–562 © 2011 by the Society for Academic Emergency Medicine Abstract Objectives: Oral examination is a method used to evaluate emergency medicine (EM) residents and requirement board certification of physicians. Second Life (SL) virtual three‐dimensional (3‐D) immersive learning environment that has been medical education. In this study we explore use SL simulation technology administer mock oral examinations EM residents. Methods: This was prospective...

10.1111/j.1553-2712.2011.01064.x article EN Academic Emergency Medicine 2011-04-26

Introduction: Practicing a medical history using standardized patients is an essential component of school curricula. Recent advances in technology now allow for newer approaches practicing and assessing communication skills. We describe herein virtual patient (VSP) system that allows students to practice their taking skills receive immediate feedback.Methods: Our VSPs consist artificially intelligent, emotionally responsive 3D characters which communicate with natural language. The...

10.1080/0142159x.2019.1616683 article EN Medical Teacher 2019-06-22

The dose-response effects of a single administration Nal-Lys-GnRHant (antagonist) on serum LH and FSH concentrations were compared to the Nal-Glu-GnRHant in monkeys. Twenty ovariectomized monkeys divided into four sc treatment groups: a) 1.0 mg/kg Nal-Glu-GnRHant; or at b) 0.3; c) 1.0; d) 3.0 mg/kg. Each monkey received vehicle (propylene glycol/water, 1:1) day 0, followed by an antagonist preparation 11. Serum measured RIA; was also vitro bioassay. short-term similar among groups....

10.1210/jcem-67-6-1325 article EN The Journal of Clinical Endocrinology & Metabolism 1988-12-01

Introduction: The oral examination is a traditional method for assessing the developing physician’s medical knowledge, clinical reasoning and interpersonal skills. typical face-to-face encounter in which examiners quiz examinees on how they would confront patient case. advantage of exam that examiner can adapt questions to examinee’s response. disadvantage potential bias intimidation. Computer-based virtual simulation technology has been widely used gaming industry. We wondered whether could...

10.5811/westjem.2015.1.24344 article EN cc-by Western Journal of Emergency Medicine 2015-03-23

The two-cell theory predicts that follicular steroidogenesis requires the coordinate actions of both FSH and LH; however, role LH in growth is less clear. present study was designed to investigate relative importance steroidogenesis. Cynomolgus monkeys were treated with a GnRH antagonist (antide; 3 mg/kg.day) for 20 days beginning midluteal phase menstrual cycle. After 10 antide administration, injected recombinant human (rhFSH; IU; n = 3), menopausal gonadotropin (hMG; or plus 0.5 IU (n 3)...

10.1210/jcem.79.1.8027261 article EN The Journal of Clinical Endocrinology & Metabolism 1994-07-01
Coming Soon ...