A5053948749- Mycobacterium research and diagnosis
- Animal Virus Infections Studies
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Viral gastroenteritis research and epidemiology
- Biosimilars and Bioanalytical Methods
- Lung Cancer Treatments and Mutations
- Eosinophilic Esophagitis
- Plant Virus Research Studies
- Virology and Viral Diseases
- Pharmacogenetics and Drug Metabolism
- Fungal Infections and Studies
- Lung Cancer Research Studies
- Antifungal resistance and susceptibility
- Cancer therapeutics and mechanisms
- Pregnancy and Medication Impact
- Microscopic Colitis
- Medical and Biological Ozone Research
- Sperm and Testicular Function
- SARS-CoV-2 and COVID-19 Research
- Reproductive System and Pregnancy
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
National Taiwan University
2025
Duke University
2025
Columbia University
2024
Memorial Sloan Kettering Cancer Center
2024
Columbia University Irving Medical Center
2023
University of Wisconsin–Madison
2020-2023
Purdue University West Lafayette
2001-2022
Certara (United States)
2017-2022
Integra LifeSciences (United States)
2020-2022
University of California, Los Angeles
2022
Abstract Background Chest Computed tomography (CT) scans detect lung nodules and assess pulmonary fibrosis. While fibrosis indicates increased cancer risk, current clinical practice characterizes nodule risk of malignancy based on size smoking history; little consideration is given to the fibrotic microenvironment. Purpose To evaluate effect incorporating microenvironment into classifying in chest CT images using deep learning techniques. Materials methods We developed a visualizable 3D...
Carnitine has antioxidant properties that protect sperm membranes against toxic reactive oxygen species. also functions to reduce the availability of lipids for peroxidation by transporting fatty acids into mitochondria beta-oxidation generate adenosine triphosphate (ATP) energy. Because effects this supplemental amino acid on reproductive performance avian breeder male are unknown, objective current study was evaluate role dietary L-carnitine semen traits and testicular histology in Leghorn...
Efficient attachment and ingestion of Mycobacterium avium subsp. paratuberculosis by cultured epithelial cells requires the expression a fibronectin (FN) protein homologue (FAP-P) which mediates FN binding M. paratuberculosis. Invasion Peyer's patches occurs through M cells, which, unlike other intestinal express integrins on their luminal faces. We sought to determine if interaction between FAP-P soluble enabled targeting invasion in vivo via these surface integrins. Wild-type antisense...
Abstract Ceritinib is a potent inhibitor of anaplastic lymphoma kinase (ALK), which has shown acceptable safety and substantial antitumor activity in ALK‐positive non–small cell lung cancer (NSCLC) patients. Two food‐effect studies were conducted healthy adults to investigate the influence food on oral bioavailability ceritinib: study with low‐ or high‐fat meals at 500 mg light snack 750 mg. Compared fasted state, AUC 0‐∞ (90%CI) ceritinib was increased by 58% (34%, 86%) after intake low‐fat...
10005 Background: Ceritinib is a potent ALK inhibitor with durable efficacy in adult pts ALK-translocated non-small cell lung cancer. This report describes the results of phase I study (NCT01742286) pediatric ALK-aberrant malignancies: anaplastic large lymphoma (ALCL); myofibroblastic tumor (MT)/inflammatory (IMT) rhabdomyosarcoma (RMS) and neuroblastoma (NB). In these tumors aberrations differ: ALCL IMT carry gene translocations, NB amplifications or mutations, RMS copy number gain no...
ABSTRACT Attachment and ingestion of Mycobacterium avium subsp. paratuberculosis by two epithelial cell lines were enhanced soluble fibronectin (FN). Peptide blocking the FN attachment protein (FAP-P) inhibited internalization M. paratuberculosis. Disruption FAP-P expression significantly reduced T-24 Caco-2 cells. The results indicate that interaction between facilitates
The purpose of the present study was to determine if supplementation ascorbic acid (AA) diet would have a beneficial effect on infectious bursal disease (IBD) vaccination chickens for protection against virus (IBDV) infection. Two hundred forty specific pathogen-free (SPF) were divided into eight experimental groups. A 2 x factorial arrangement in completely randomized design used; AA at 1,000 ppm diet, vaccination, and challenge main effects. Prior 10 d after challenge, serum concentration,...
ABSTRACT Attachment of Mycobacterium avium subsp. paratuberculosis to host tissue and penetration mucosal surfaces are pivotal events in the pathogenesis Johne's disease. Fibronectin (FN) binding is required for attachment internalization several mycobacteria by epithelial cells vitro. The objective this study was further characterize FN activity M. . Although bacteria bound poorly at pH above 7, brief acid pretreatment greatly enhanced within range (3 10) studied. A 4.6-kbp fragment from an...
Access lag to innovative therapies in Asian populations continues present a challenge global health. Recent progressive changes the regulatory landscape, including newer guidelines, are enabling simultaneous drug development and near-simultaneous registration. The International Conference on Harmonization (ICH) E17 guideline outlines general principles for design analysis of multiregional clinical trials (MRCTs). We posit that translational research quantitative pharmacology tools core...
Voriconazole is an azole antifungal utilized for prophylaxis and treatment of invasive fungal infections in hematologic patients. Previous studies have revealed decreased efficacy increased toxicity with subtherapeutic <1 mcg/mL supratherapeutic > 4 levels. A voriconazole dose modification guideline was introduced July 2014 based on a retrospective analysis.The primary objective to evaluate the guideline. Secondary objectives were identify patient-specific characteristics that contribute...
DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 101:207-215 (2012) - DOI: https://doi.org/10.3354/dao02527 Quality control ranges for testing broth microdilution susceptibility Flavobacterium columnare and F. psychrophilum nine antimicrobials Charles M. Gieseker1,*, Tamara D. Mayer1, Tina C. Crosby1, Jeremy Carson2, Inger Dalsgaard3, Ahmed Darwish4, Patricia S....
The safety of inflammatory bowel disease medications during lactation is significant relevance to women childbearing potential. Available data regarding the transfer biologic agents for via breast milk are limited case reports. objective this prospective postmarketing study was assess vedolizumab concentrations in from lactating vedolizumab-treated with disease. Breast serially collected throughout dosing interval 11 patients receiving established intravenous 300-mg maintenance therapy every...