A5048495656- Ophthalmology and Visual Health Research
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Clinical Reasoning and Diagnostic Skills
- Retinal Imaging and Analysis
- History of Medicine Studies
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Retinal Diseases and Treatments
- Telemedicine and Telehealth Implementation
- Neurological Complications and Syndromes
- Neuroscience of respiration and sleep
- Radiology practices and education
- Ophthalmology and Eye Disorders
- Syphilis Diagnosis and Treatment
- Sleep and Wakefulness Research
- Neurological and metabolic disorders
- Vascular Malformations Diagnosis and Treatment
- Toxoplasma gondii Research Studies
- Trigeminal Neuralgia and Treatments
- Child Abuse and Related Trauma
- Meningioma and schwannoma management
- Intraocular Surgery and Lenses
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
Indiana University – Purdue University Indianapolis
2015-2024
Indiana University School of Medicine
2015-2024
Indiana University
2015-2023
University School
2018-2023
Indiana University Indianapolis
2017-2019
Emory University
2013-2015
Neurological Surgery
2015
Brigham and Women's Hospital
2012-2014
NYU Langone Health
2014
Harvard University
2013
The breathing motor pattern in mammals originates brainstem networks. Whether pacemaker neurons play an obligatory role remains a key unanswered question. We performed whole-cell recordings the preBötzinger Complex slice preparations from neonatal rodents and tested for activity. observed persistent Na + current ( I NaP )-mediated bursting ∼5% of inspiratory postnatal day 0 (P0)-P5 P8-P10 slices. -mediated was voltage dependent blocked by 20 μ m riluzole (RIL). found Ca 2+ )-dependent 7.5%...
Inspiratory neurons of the preBötzinger complex (preBötC) form local excitatory networks and display 10–30 mV transient depolarizations, dubbed inspiratory drive potentials , with superimposed spiking. AMPA receptors are critical for rhythmogenesis under normal conditions in vitro but whether other postsynaptic mechanisms contribute to potential generation remains unknown. We examined synaptic intrinsic membrane properties that generate preBötC using neonatal mouse medullary slice...
Phox2b is required for development of the peripheral autonomic nervous system and a subset cranial nerves lower brainstem nuclei. mutations in man cause diffuse dysfunction deficits automatic control breathing. Here we study distribution adult rat hindbrain to determine whether this protein selectively expressed by neurons involved respiratory control. In medulla oblongata, Phox2b-immunoreactive nuclei were present dorsal vagal complex, intermediate reticular nucleus, dorsomedial spinal...
Ocular funduscopy appears to be a dying art. Physicians and medical students alike lack confidence in the use of an ophthalmoscope. As result, few clinicians perform ophthalmoscopy, many who do are unable reliably detect abnormalities ocular fundus. Approaches remediation undergraduate education have included simulators, longitudinal skill reinforcement, Web-based teaching, other techniques. Preservation ophthalmoscopic art has been hindered by technical difficulty, waning enthusiasm for...
Breathing movements in mammals depend on respiratory neurons the preBötzinger Complex (preBötC), which comprise a rhythmic network and generate robust bursts that form basis for inspiration. Persistent Na + current ( I NaP ) is widespread preBötC hypothesized to play critical role rhythm generation because of its subthreshold activation slow inactivation properties putatively promote long‐lasting burst depolarizations. In neonatal mouse slice preparations retain respiratory‐related rhythm,...
Background: While large language models (LLMs) are increasingly used in medicine, their effectiveness compared with human experts remains unclear. This study evaluates the quality and empathy of Expert + AI, experts, LLM responses neuro-ophthalmology. Methods: randomized, masked, multicenter cross-sectional was conducted from June to July 2023. We randomly assigned 21 neuro-ophthalmology questions 13 experts. Each expert provided an answer then edited a ChatGPT-4–generated response, timing...
Background: Neuro-ophthalmologists specialize in complex, urgent, vision- and life-threatening problems, diagnostic dilemmas, management of complex work-ups. Access is currently limited by the relatively small number neuro-ophthalmologists, consequently, patients may be affected incorrect or delayed diagnosis. The objective this study to analyze referral patterns characterize rates misdiagnoses diagnoses ultimately referred, delineate outcomes after neuro-ophthalmologic evaluation. Methods:...
The novel coronavirus 2019 (COVID-19) pandemic has transformed health care. With the need to limit COVID-19 exposures, telemedicine become an increasingly important format for clinical Compared with other fields, neuro-ophthalmology faces unique challenges, given its dependence on physical examination signs that are difficult elicit outside office setting. As such, it is imperative understand both patient and provider experiences continue adapt technology tailor application. purpose of this...
Background: The eye has been considered a ‘window to the brain,’ and several neurological diseases including neurodegenerative conditions like Alzheimer’s disease (AD) also show changes in retina. Objective: To investigate retinal nerve fiber layer (RNFL) thickness its association with brain volume via magnetic resonance imaging (MRI) older adults subjective or objective cognitive decline. Methods: 75 participants underwent ophthalmological evaluation optical coherence tomography MRI (28...
To report the clinical features and treatment outcomes of patients with peripapillary choroidal neovascular membrane (CNVM) secondary to idiopathic intracranial hypertension (IIH).
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Report a case of concurrent unilateral optic neuritis and central retinal artery occlusion as the presenting signs syphilis.A report 22-year-old man with progressive vision loss.With no known previous history syphilis, genital lesions, or other extraocular manifestations, patient presented pain eye movements decreased color vision. His dramatically worsened after course oral steroids. Examination was remarkable for severe right disk edema macular cherry-red spot mild posterior uveitis....
The proficiency of nonophthalmologists with direct ophthalmoscopy is poor, which has prompted a search for alternative technologies to examine the ocular fundus. Although fundus photography existed decades, its use been traditionally restricted ophthalmology clinical care settings and textbooks. Recent research shown role nonmydriatic in nonophthalmic settings, encouraging more widespread adoption technology. studies have also affirmed as an adjunct or undergraduate medical education. In...
The COVID-19 public health emergency (PHE) has significantly changed medical practice in the United States, including an increase utilization of telemedicine. Here, we characterize change neuro-ophthalmic care delivery during early PHE, a comparison delivered via telemedicine and office.Neuro-ophthalmology outpatient encounters from 3 practices States (4 providers) were studied PHE (March 15, 2020-June 2020) same dates 1 year prior. For unique patient visits, demographics, visit types,...
Intracranial hypertension is rarely associated with peripheral hemodialysis shunts, presumably in association central venous stenosis.1,2 Hemodialysis Reliable Outflow (HeRO) grafts (CryoLife, Inc., Kennesaw, GA) are designed to bypass preexisting stenosis by connecting the brachial artery circulation through ipsilateral internal jugular vein (IJV) (figure, C and D).3 We report a case of intracranial immediately after placement HeRO graft, review similar cases medical literature, discuss...
An 81-year-old man with retinitis pigmentosa had severe, slowly progressive visual loss that began at age 20. Intermittent nystagmus was observed for 1 decade. Examination revealed severe retinal atrophy and periodic alternating (PAN) occurred only in darkness (video on the Neurology® Web site [www.neurology.org][1]). [1]: http://www.neurology.org/