A5029371595- Opioid Use Disorder Treatment
- Traffic and Road Safety
- Emergency and Acute Care Studies
- Injury Epidemiology and Prevention
- Cardiac Arrest and Resuscitation
- Poisoning and overdose treatments
- Forensic Toxicology and Drug Analysis
- Crystallization and Solubility Studies
- Trauma and Emergency Care Studies
- X-ray Diffraction in Crystallography
- Animal Virus Infections Studies
- African history and culture studies
- Pregnancy and Medication Impact
- Homicide, Infanticide, and Child Abuse
- Pain Management and Opioid Use
- Animal Disease Management and Epidemiology
- Suicide and Self-Harm Studies
- Data-Driven Disease Surveillance
- Primary Care and Health Outcomes
- Reproductive System and Pregnancy
- Occupational Health and Performance
- Crystallography and molecular interactions
- Acute Lymphoblastic Leukemia research
- Alcohol Consumption and Health Effects
- Health Systems, Economic Evaluations, Quality of Life
University of Washington
2021-2024
Institute of Translational Health Sciences
2021-2024
University of Kentucky
2011-2021
Lawrence Livermore National Laboratory
2019-2020
Kentucky Department for Public Health
2017-2018
Georgia Southern University
2013
University of Central Florida
2004-2008
National Jewish Health
1996-2001
University of Colorado Denver
1996-2001
University of Arizona
1999
It has long been stated that six people are left behind following every suicide. Despite a lack of empirical evidence, this extensively cited for over 30 years. Using data from random‐digit dial survey, more accurate number exposed to each suicide is calculated. A sample 1,736 adults included 812 lifetime suicide‐exposed respondents who reported age and exposures. Each resulted in 135 (knew the person). affects large circle people, may be need clinician services or support exposure.
Vaccines against SARS-CoV-2 are highly effective in preventing COVID-19 illness. 1,2Research has found that is associated with adverse events pregnancy, 3 and recommendations therefore include offering vaccines to pregnant lactating individuals, despite their lack of inclusion initial clinical trials. 4,5To date, limited data on vaccine pregnancy outcomes exist for lactation. 6The objective this study was investigate experiences individuals after receiving vaccines. MethodsIn January 2021,...
ABSTRACT The chloroplast bioreactor is an alternative to fermentation-based systems for production of vaccine antigens and biopharmaceuticals. We report here expression the plague F1-V fusion antigen in chloroplasts. Site-specific transgene integration homoplasmy were confirmed by PCR Southern blotting. Mature leaves showed highest level on third day continuous illumination, with a maximum 14.8% total soluble protein. Swiss Webster mice primed adjuvant-containing subcutaneous (s.c.) doses...
Despite evidence that motorcycle helmets reduce morbidity and mortality, helmet laws rates of use vary by state in the U.S.We pooled data from eleven states: five with universal requiring all motorcyclists to wear a helmet, six partial only subset helmet. Data were combined Crash Outcome Evaluation System's General Use Model included crash records probabilistically linked emergency department inpatient discharges for years 2005-2008. Medical outcomes compared between law settings. We...
<h3>Importance</h3> COVID-19 vaccine boosters or third doses are recommended for adolescents and adults who completed their initial course more than 5 months prior. Minimal data available on booster dose reactogenicity among pregnant lactating individuals. <h3>Objective</h3> To describe the reactions to of experiences <h3>Design, Setting, Participants</h3> Beginning in October 2021, a follow-up Research Electronic Data Capture (REDCap) survey regarding was sent 17 504 participants an ongoing...
The majority of motor vehicle occupants who were killed or hospitalized in crashes Kentucky 2000-2001 occupied vehicles that severely damaged the crash. Even so, overall only a small percentage all hospitalized. purpose was to identify occupant, vehicle, crash, and roadway/environmental factors associated with increased risk severe injury where occupant's damaged.This study probabilistically linked Kentucky's statewide crash inpatient hospital discharge data files for 2000 2001, selected...
Although numerous observational studies have demonstrated a protective effect of motorcycle helmets against head injury, the degree protection specific injury types remains unclear. Experimental biomechanics involving cadavers, animals, and computer models established that injuries varying etiologies. This retrospective cross-sectional study compared helmet skull fracture, cerebral contusion, intracranial hemorrhage, concussion in consecutive series operators involved recent traffic crashes...
Abstract In the periphery αβ T lymphocytes recognize antigens in conjunction with major histocompatibility complex (MHC) molecules. thymus immature cells are positively selected on MHC molecules apparent absence of cognate peptides. Thus, at different developmental stages a cell responds to epitopes, yet uses identical antigen receptor (TcR). To explain this paradox it has been hypothesized that during positive selection see peptides/ligands unique thymus, by specific antagonists related...
Background According to the National Center for Health Statistics, Kentucky had third highest drug overdose fatality rate in nation 2015 at 29.9 fatalities per 100 000 population. Objective The elevated necessitated development and implementation of a comprehensive multisource surveillance system (DOFSS). Methods DOFSS stakeholder work group members data sources were identified, memorandums understanding established. following used establish DOFSS: (1) death certificates; (2) autopsy...
The study objective was to determine the minimum frequency of dosing for standard 4-g doses p-aminosalicylic acid (PAS) granules. Two sequential six-patient pharmacokinetic studies are described, followed by clinical data from 40 subsequent patients. All patients had multidrug-resistant tuberculosis (MDR-TB). Serum collected at two three time points after dosing, and assayed a validated high performance liquid chromatography (HPLC) assay. Data were analyzed using noncompartmental methods. In...
OBJECTIVE: To determine the pharmacokinetics and relative bioavailability of para-aminosalicylic acid (PAS) granules. DESIGN: Phase I study. SETTING: University Arizona School Pharmacy. PARTICIPANTS: Sixteen healthy male female volunteers aged 36 ± 8 years. INTERVENTIONS: Subjects received single doses PAS granules (6 g) combined with cycloserine 500 mg, clofazimine 200 ethionamide pyridoxine 100 mg. Drugs were given on an empty stomach after overnight fast (reference) high-fat food, orange...
Summary Reasons for performing study Exercise‐induced pulmonary haemorrhage ( EIPH ) is reported as a performance limiting condition in racehorses, yet few longitudinal studies characterising have been reported. Objectives To characterise during training and racing the absence of prophylactic medication with furosemide among horses imported to H ong K 2007–2012. Study design Retrospective descriptive clinical endoscopy, status, records. Methods Thoroughbred geldings (n = 822) from N ew Z...
Increases in asthma and obesity over the past three decades have led to speculation about a causal link between two diseases. However, investigations of relationship body mass index (BMI) fractional exhaled nitric oxide (FeNO) - marker eosinophilic airway inflammation produced mixed results. The purpose this study was evaluate (BMI), FeNO sample U.S. adults using data from National Health Nutrition Examination Surveys (NHANES) for 2007-2010.We assessed BMI subjects with without categorical...
Emergency departments (EDs) serve a wide range of patients who present at risk impending suicide and homicide.Two statewide surveillance systems were probabilistically linked to understand utilizes EDs then dies violently within 6 weeks.Each identified case was matched with four randomly selected controls on sex, race, date birth, resident zip code, ED visit vs. death. Matched-pair odds ratios estimated by conditional logistic regression assess differences between cases reported diagnoses...
Abstract Purpose The methadone poisoning death rate for Kentucky in the year 2005 was sixth highest US and increased 17‐fold from 1999 to 2005. purpose of this study identify characterize related poisonings using multiple data sources: inpatient hospitalization discharge data, poison control center vital statistics mortality All Schedule Prescription Electronic Reporting (KASPER) data. Methods A descriptive analysis performed on Regional Poison Center (KRPC) KASPER Results While prescription...
Abstract Introduction Co-morbid post-traumatic stress disorder (PTSD) and low back pain (LBP) are common reasons for increased disability in the Veteran communities. Medical discharge from military represents a considerable financial cost to society. Little is currently known about impact of LBP PTSD as longitudinal risk factors medical Active Duty service. Materials Methods A retrospective analysis US Army Soldiers 2002 2012 was performed determine discharge. Four levels exposure were...
Women with systemic lupus erythematosus (SLE) are vulnerable to cervical dysplasia due the persistence of human papillomavirus (HPV) infection. The objective this cross-sectional retrospective study was investigate prevalence cancer screening according American Society for Colposcopy and Cervical Pathology (ASCCP) SLE-specific guidelines. We also aimed identify determinants associated ASCCP adherence.Women aged 21 64 years enrolled in our institutional SLE registry were included study....
Abstract Purpose Native Americans and Latinos have higher COVID‐19 infection mortality rates may limited access to diagnostic testing. Home‐based testing improve care in rural underserved populations. This study tests the effect of community health worker (CHW) support on accessibility, feasibility, completion home among American Latino adults living Flathead Reservation Montana Yakima Valley, Washington. Methods A two‐arm, multisite, pragmatic randomized controlled trial was conducted using...
ObjectiveThe aim of this project was to explore changing patterns in patient refusal transport by emergency medical services for classified heroin overdoses and possible implications on overdose surveillance Kentucky.IntroductionAs a Centers Disease Control Prevention Enhanced State Opioid Overdose Surveillance (ESOOS) funded state, Kentucky started utilizing Emergency Medical Services (EMS) data increase timeliness state drug events late 2016. Using developed definitions EMS runs, analyzed...