A5100666760- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Plant and Fungal Interactions Research
- Monoclonal and Polyclonal Antibodies Research
- Biomarkers in Disease Mechanisms
- S100 Proteins and Annexins
- Autophagy in Disease and Therapy
- Protein Tyrosine Phosphatases
- Selenium in Biological Systems
- Cancer-related Molecular Pathways
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Cleft Lip and Palate Research
- Pediatric health and respiratory diseases
- Cell Adhesion Molecules Research
- Respiratory viral infections research
- Sulfur Compounds in Biology
- Infrared Thermography in Medicine
Shanghai Changzheng Hospital
2024
Hunan Cancer Hospital
2020-2024
Central South University
2020-2024
Second Military Medical University
2024
Nagoya University
2024
Nanchang University
2023
First Affiliated Hospital of Nanchang University
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2021
Daping Hospital
2020
Jiangsu Province Hospital
2020
Within the family of RTKs (receptor tyrosine kinases), PDGFR (platelet-derived growth factor receptor) has been implicated in carcinogenesis and tumour development. miRNAs (microRNAs), which can target mRNAs (messenger RNAs) cancer-associated genes, are abnormally expressed various cancers. In this study, our aim was to identify that PDGFR-α/β study functions these miRNAs. miR-34a predicted PDGFR, luciferase reporter assays showed could directly PDGFR. Meanwhile, we found down-regulated...
Osteoarthritis (OA) is the most common arthritis that characterized by progressive synovial inflammation and loss of articular cartilage. Although GYY4137 a novel slow-releasing hydrogen sulfide (H2S) donor with potent anti-inflammatory properties may modulate progression OA, its underlying mechanism remains unclear. In this study, we validated protective role against OA pathological courses elucidated regulatory mechanisms. Cell transfection, immunofluorescence staining, EdU assay,...
NRP1 as multifunctional non-tyrosine-kinase receptors play critical roles in tumor progression. MicroRNAs (miRNAs) are an important class of pervasive genes that involved a variety biological functions, particularly cancer. It remains unclear whether miRNAs can regulate the expression NRP1. The goal this study was to identify could inhibit growth, invasion and metastasis gastric cancer by targeting expression. We found miR-338 reduced cell lines tissues. Moreover, we inhibited migration,...
MicroRNAs (miRNAs) are abnormally expressed in various types of cancer. miR-130a expression and function gastric cancer has yet to be elucidated. The aim the present study was identify examined cell lines tissues by RT-qPCR. diagnostic prognostic significance analyzed receiver-operating characteristic (ROC) curve Kaplan-Meier analysis. miR130a identified serum patients healthy controls using RT-qPCR ROC curves, respectively. A target gene for luciferase reporter assays, tumorigenesis ability...
This study aimed to investigate the role of long noncoding RNAs (lncRNAs) in metastasis colorectal cancer (CRC). Metastasis is an important prognostic factor CRC, and lncRNAs have been implicated tumor proliferation metastasis. The human CRC cell lines HCT116, HT29, SW480, DLD-1, SW620 were used study. Genome-wide lncRNA expression patterns metastatic lymph nodes compared with paired normal assessed by microarray analysis. Gastric adenocarcinoma predictive intergenic (GAPLINC) RNA was...
Abstract Background Long noncoding RNAs (lncRNAs) have emerged as key regulators in multiple cancers, including colorectal cancer (CRC). However, the biological functions and molecular mechanisms underlying most lncRNAs CRC remain largely unknown. Methods A novel lncRNA (TCONS_00012883) was identified using RNA sequencing. The level of TCONS_00012883 expression analyzed by qRT‐PCR. were investigated a series vitro vivo experiments: CCK8, colony formation, EdU, flow cytometric assays,...
Abstract Chemoresistance is a major cause of high mortality and poor survival in patients with ovarian cancer (OVCA). Understanding the mechanisms chemoresistance urgently required to develop effective therapeutic approaches OVCA. Here, we show that expression long noncoding RNA, taurine upregulated gene 1 (TUG1), markedly samples from OVCA who developed resistance primary platinum‐based therapy. Depletion TUG1 increased sensitivity cisplatin cell lines, SKOV3 KURAMOCHI. Combination therapy...
MicroRNAs (miRNAs) are small non-coding RNAs that play pivotal roles in cancer initiation and progression. However, the molecular mechanisms of miRNAs colorectal (CRC) progression remain unclear. Here, we show downregulation miR-1224-5p CRC is negatively correlated with SP1 expression metastasis patients xenografted mouse models. Gain- loss-of-function assays reveal suppresses migration, invasion, epithelial-mesenchymal transition (EMT) cells vitro vivo by directly targeting SP1. Moreover,...
Recently, substantial evidence has demonstrated that pseudogene derived lncRNAs are crucial regulators of cancer development and progression. DUXAP10,a long non-coding RNA(lncRNA), is overexpression in colorectal (CRC), but its expression pattern, biological function underlying mechanism CRC still undetermined. In this study, we observed DUXAP10 was up-regulated tissues which positively correlated with advanced pathological stages, larger tumor sizes lymph node metastasis. Additionally,...
Epithelial‑to‑mesenchymal transition (EMT) is believed to be associated with cancer cell malignancy, and also cause invasion metastasis. Recent evidence indicates that small non‑protein coding RNA [microRNAs (miRNAs/miRs)] may act as powerful regulators of EMT. The present study aimed systematically delineate miR‑503 expression in gastric analyse the function In study, was detected lines tissues by quantitative polymerase chain reaction. Gastric migration, proliferation capabilities were...
Ebselen a selenoorganic compound showing glutathione peroxidase like activity is an anti-inflammatory and antioxidative agent. Its cytoprotective has been investigated in recent years. However, experimental evidence also shows that ebselen causes cell death several cancer types whose mechanism not yet elucidated. In this study, we examined the effect of on multiple myeloma (MM) lines vitro. The results showed significantly enhanced production reactive oxygen species (ROS) accompanied by...
Abstract: A number of studies have revealed that nuclear paraspeckle assembly transcript 1 (NEAT1), a long noncoding RNA (lncRNA), was aberrantly regulated in various cancers. High NEAT1 expression associated with poor prognosis and an increased risk lymph node metastasis (LNM) cancer patients. This meta-analysis conducted to identify the potential value as biomarker for prognosis. We searched electronic databases PubMed, Web Science, China National Knowledge Infrastructure (up November 13,...
miR-128 is expressed in various tumors, but its expression and function gastric cancer have not been defined. Thus, the goal of this study was to characterize cancer. We found first that down-regulated cell lines tissues, dysregulation correlated with DNA methylation transcription factor SNAIL. Using prediction tools, western blotting, luciferase reporter assays, we Bmi-1 direct target miR-128. Additionally, overexpression inhibited migration, invasion, proliferation by targeting vitro vivo....
Long noncoding RNAs (lncRNAs) have been shown to critical regulatory roles in tumorigenesis. lncRNA LINC01561 (LINC01561) is a newly identified tumor-related and its dysregulation has demonstrated several tumors. However, whether involved the progression of non-small-cell lung carcinoma (NSCLC) underlying mechanisms remain unknown. In this study, we first provided evidence that expressions were distinctly upregulated NSCLC tissues cell lines. Combining with bioinformatics assays mechanism...
Numbers of studies suggest that long non-coding RNAs (lncRNAs) exert an important role in cancer progression. It is reported lncRNA SNHG14 (SNHG14) promotes cell proliferation and invasion many cancers. However, the underlying molecular mechanism colorectal (CRC) remains unclear. In our study, we found highly expressed CRC tissues cells, especially SW480 HT-29 cells. addition, sh-SNHG14 inhibits proliferation, migration invasion, apoptosis lines. Furthermore, functions as a sponge for...
Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis. Considerable evidence indicates that autophagy non-coding RNA play essential roles in the biological processes involved cancers, but associations between autophagy-related long RNAs (lncRNAs) HNSCC remain unclear. In present study, sequences gene data were extracted from The Cancer Genome Atlas database Human Autophagy Database. A total of 1,153 lncRNAs selected via calculating Pearson’s correlation coefficient. Three...
Abstract Postembryonic angiogenesis is mainly induced by various proangiogenic factors derived from the original vascular network. Previous studies have shown that role of Ang‐2 in controversial. Tip cells play a vanguard and exhibit transdifferentiated phenotype under action angiogenic factors. However, whether promotes transformation endothelial to tip remains unknown. Our study found miR‐221‐3p was highly expressed HCMECs cultured for 4 h hypoxic conditions (1% O 2 ). Moreover,...
Abstract: Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total 390 lncRNA transcripts and 508 mRNA were dysregulated tumor tissues compared paired metastatic nodes. Functional prediction showed that lots might be involved pathways related to CRC by cis -regulation trans coexpressed genes. As representative, ENST00000430471...
Synovitis plays an important role in the pathogenesis of arthritis, which is closely related to joint swell and pain patients. The purpose this study was investigate anti-inflammatory effects pulsed electromagnetic fields (PEMF) on synovitis its underlying mechanisms. Destabilization medial meniscus (DMM) model air pouch inflammation were established induce C57BL/6 mice. mice then treated by PEMF (pulse waveform, 1.5 mT, 75 Hz, 10% duty cycle). scores as well levels IL-1 β TNF- α suggested...
An experimental autoimmune myocarditis rat model was established by subcutaneous injection of porcine myocardial myosin (PCM). The effect ET-1 receptor type B (ETBR) overexpression on observed via tail vein ETBR lentivirus in rats. We further investigated the mechanisms involved regulation overexpression.Six rats were randomly selected from 24 male Lewis as NC group, and remaining 18 injected with PCM Day 0 7, to establish (EAM) model. initially immunized divided into three groups: EAM...