A5026720998- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- COVID-19 and healthcare impacts
- Telemedicine and Telehealth Implementation
- Oral and Maxillofacial Pathology
- Allergic Rhinitis and Sensitization
- Emergency and Acute Care Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Bone Tumor Diagnosis and Treatments
- Patient Satisfaction in Healthcare
- Respiratory and Cough-Related Research
- Infectious Diseases and Mycology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nosocomial Infections in ICU
- Soft tissue tumor case studies
- Pediatric health and respiratory diseases
- Lung Cancer Treatments and Mutations
- Healthcare Systems and Technology
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Pituitary Gland Disorders and Treatments
University of Pennsylvania
2018-2024
University of Pennsylvania Health System
2019-2020
Children's Hospital of Philadelphia
2019
Istituto Tumori Bari
1993
Abstract Background In light of the COVID‐19 pandemic, there has been a rapid increase in telemedicine visits. Otolaryngology patient satisfaction with these visits not yet extensively studied using validated survey. Methods All patients who had three head and neck surgeons, by phone or video‐based platform, between March 25, 2020 April 24, 2020. Retrospective chart reviews were conducted to determine demographic, disease, treatment information. Patients video visit contacted telephone and,...
Objective During the COVID‐19 pandemic, there has been unprecedented use of telemedicine for otolaryngology ambulatory visits. Patient satisfaction with is an important metric, but survey‐based questionnaires do not capture nuances patient experience. This study aims to understand head and neck patients’ perceptions about clinic visits during COVID‐19. Methods Fifty‐six established patients who had video‐based otolaryngology–head surgery faculty member between March 25, 2020, April 24,...
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is commonly characterized by type‐2 inflammation. It established that group‐2 innate lymphoid cells (ILC2s) are a subset of immune important in orchestrating mucosal response. IL‐25 an epithelial‐derived cytokine critical activator ILC2s. Recent evidence demonstrates specialized taster epithelial cells, such as solitary chemosensory (SCCs), may be producers IL‐25. To elucidate the relationship between SCCs and ILC2s CRSwNP, we...
Solitary chemosensory cells (SCCs) are rare epithelial enriched in nasal polyps and the primary source of interleukin-25 (IL-25), an innate cytokine eliciting T-helper 2 (Th2) immune response. Although it is proposed that SCCs stimulated by antigens released upper airway pathogens, exogenous triggers human remain elusive. We studied patients with noninvasive fungal rhinosinusitis to determine whether extracts Aspergillus fumigatus Alternaria alternata stimulate SCC proliferation as early...
Background Inverted papilloma (IP) is a benign sinonasal tumor with well‐known propensity to recur, especially at its bony attachment site. Anecdotal evidence suggests lower rate of recurrence in primary resection. We also aimed evaluate the effect multifocal vs single focus disease control. Methods This work retrospective review 535 IP resections performed during period from 2006 2016 tertiary‐care center. Demographic data, location and sites, follow‐up duration data were obtained. Results...
Background Broncho‐Vaxom® (OM‐85 BV) is an extract of infectious respiratory bacteria that used as immunostimulant outside the United States for prevention and treatment bronchitis rhinosinusitis. Prior studies have shown use OM‐85 BV associated with reduction in frequency infection decreased duration antibiotic usage. However, effects on mucosal innate immunity are unknown. Methods Human sinonasal epithelial cells were grown at air‐liquid interface (ALI). Ciliary beat (CBF) nitric oxide...
Introduction Increased pharyngeal collapsibility leads to obstructive sleep apnea (OSA). Positive airway pressure titration during drug‐induced endoscopy (DISE‐PAP) provides objective metrics, the opening (PhOP), and active critical (Pcrit A ). We examined interrelationships between risk factors of OSA, measures, clinical manifestations disease. Methods This is a cross‐sectional analysis consecutive OSA patients undergoing DISE‐PAP. Nasal PAP was increased stepwise until inspiratory flow...
Pembrolizumab is a monoclonal antibody with increasing use in many malignancies. We describe case of pembrolizumab‐associated bullous pemphigoid (BP) laryngeal involvement 69‐year‐old male patient. Diagnosis was made after 2 months symptoms via biopsy concurrent, easily accessible cutaneous lesions. discontinued and the patient started on steroids dupilumab ultimate resolution his lesions while immunosuppression. This report describes third to increase awareness this rare immune‐related...
Objective Sinonasal inverted papilloma (IP) is a typically benign sinonasal tumor with tendency to recur and the potential for malignant transformation. Varying degrees of dysplasia may be present, which carcinoma in situ (CIS) most advanced. We hereby describe biological clinical behavior IP CIS (IPwCIS). Study Design Retrospective cohort. Setting Tertiary academic referral center. Subjects Methods Patients who underwent surgical resection between 2002 2017. Pertinent data were obtained,...
Objective Chronic rhinosinusitis (CRS) is a proposed risk factor for meningitis and other intracranial complications following the endoscopic endonasal transsphenoidal approach (TSA). Some have recommended staging TSA surgery CRS; however, delaying has important ramifications. The objective of this study to determine whether asymptomatic sinonasal inflammation (RSNI) on preoperative computed tomography scans, without clinical CRS, associated with postoperative TSA. Methods All consecutive...
The significance of hyoid dynamics in OSA pathophysiology remains unclear. Drug-induced sleep endoscopy (DISE) is often used for evaluating patients intolerant to positive airway pressure (PAP) therapy. We performed DISE with concurrent hyoid-focused ultrasonography quantify during obstructive and non-obstructive breathing.
Background Patients undergoing endoscopic resection of neoplasms with both sinonasal and skull base involvement can develop chronic rhinosinusitis (CRS) after treatment may occasionally benefit from additional sinus surgery (ESS). We investigate risk factors outcomes associated revision ESS (rESS) skull‐base (SBS) for combined involvement. Methods A retrospective review patients who underwent at a single tertiary care academic institution 2004 through 2017 was performed. Eighty‐three were...
Abstract Purpose This study aimed to determine the impact of uttering word “quiet” on clinical workload during overnight otolaryngology call shift and understand factors contributing resident busyness. Materials Methods A multicenter, single‐blind, randomized‐controlled trial was conducted. total 80 shifts covered by a pool 10 residents were randomized quiet or control group. At start shift, asked state aloud, “Today will be night” (quiet group) good (control group). Clinical workload, as...
To assess the impact of a novel flipped-classroom (FC) otolaryngology resident didactic curriculum on learning.Based preferences elicited in survey preferred learning styles residents, hybrid web-based and in-person FC was implemented over 6-month period 2020-2021. Resident reactions to new were assessed via second survey. Kruskal Wallis tests used compare mean stanine scores Otolaryngology Training Examination (OTE) exam for topics taught format with delivered old format.After instituting...
Abstract Background BNO 1016 is an ethanolic extract of a mixture five herbs that has been sold in different formulations for decades the European market and more recently, United States as over-the-counter treatment rhinosinusitis. Previous studies indicated activation chloride secretion increase ciliary beat frequency by but functional consequences on mucociliary transport velocity airway surface liquid homeostasis are unknown. This study intends to examine effects these properties vitro....
A 47-year-old male patient diagnosed with severe obstructive sleep apnea (OSA) sought alternatives to positive airway pressure, prompting evaluation drug-induced endoscopy (DISE). He underwent a specialized DISE nasal airflow and pharyngeal pressure monitoring. During apneas, signals demonstrated dynamic, multilevel upper collapse, shifting sites of obstruction as respiratory effort increased. This case report illustrates how quantitative measurements can complement the standard exam aid in...
Abstract Purpose To examine factors accounting for differences in hyoid motion during obstructive breathing events amongst sleep apnea (OSA) patients. Methods This was a prospective cohort study from June 2022 to October 2022. Patients with OSA undergoing evaluation PAP alternative therapies drug-induced endoscopy positive airway pressure titration (DISE-PAP). All patients underwent DISE-PAP and concurrent hyoid-focused ultrasound. enabled measurement of physiology (flow, respiratory effort)...
Background Ketotifen is a second‐generation noncompetitive H1‐antihistamine and mast‐cell stabilizer. It commonly used to treat or prevent allergic conjunctivitis, asthma, chronic urticaria, anaphylaxis, mast‐cell, other allergic‐type disorders. However, it has never been studied in aspirin‐exacerbated respiratory disease (AERD), an aggressive phenotype of rhinosinusitis with nasal polyps, where the mast cell plays prominent role its pathogenesis. Methods Human sinonasal epithelial cells...