A5014819748- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Mathematical Biology Tumor Growth
- Helicobacter pylori-related gastroenterology studies
- Radiomics and Machine Learning in Medical Imaging
- Digestive system and related health
- Hippo pathway signaling and YAP/TAZ
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Genetic factors in colorectal cancer
- PI3K/AKT/mTOR signaling in cancer
- NF-κB Signaling Pathways
- Renal and related cancers
- Mass Spectrometry Techniques and Applications
- Effects of Radiation Exposure
- Immune Response and Inflammation
University of Basel
2021-2024
University Hospital of Basel
2021-2022
Université de Sherbrooke
2017-2020
Patient-derived organoids (PDOs) represent promising preclinical models in various tumor types. In the context of prostate cancer (PCa), however, their establishment has been hampered by poor success rates, which impedes broad use for translational research applications. Along with necessity to improve culture conditions, there is a need identify factors influencing outcomes and determine how assess versus failure organoid generation. present study, we report our unbiased efforts generate...
Abstract Patient-derived organoids (PDOs) offer new opportunities to model various cancers. However, their application in prostate cancer (PCa) has been hampered by poor success rates and overgrowth of cell types which are not representative the patient samples. By exploiting a cohort 164 PCa samples tuning several culture parameters, we show that an extracellular matrix-free (ECM)-free system increases take-rate PDOs with luminal-like features. Single-cell RNA sequencing (scRNA-seq) reveals...
NOT PUBLISHED AT AUTHOR’S REQUEST CIHR
NOT PUBLISHED AT AUTHOR’S REQUEST Funding Agencies: CIHR
New components of the intestinal stem cell niche are constantly being discovered. Recently, subepithelial Foxl1 + telocytes (TC Foxl1+ ) were found to play a key role in maintaining and regulating crypt homeostasis. TC produce crucial such as WNT2b, WNT5a RSPO3 well Bone Morphogenic Proteins (BMP) inhibitors Gremlin 1 2. Previous work our laboratory showed that epithelial BMP signaling is involved terminal differentiation maturation cells from secretory lineage. Our recent loss mesenchymal...
Abstract Introduction: An important clinical need remains to improve survival of men with advanced metastatic prostate cancer (PCa). A better understanding the mechanisms underlying PCa progression and treatment resistance is a prerequisite address this challenge, which currently limited by scarcity experimental models. Here, we aimed at establishing characterizing new patient-derived organoids xenograft (PDOX) models PCa. Materials & methods: We used two organoid lines (PDOs),...