A5004778417- Cancer Treatment and Pharmacology
- Tryptophan and brain disorders
- Biochemical Acid Research Studies
- Stress Responses and Cortisol
- Graphene and Nanomaterials Applications
- Glioma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Acute Kidney Injury Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pancreatic and Hepatic Oncology Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA Interference and Gene Delivery
Daegu-Gyeongbuk Medical Innovation Foundation
2019-2021
Korea Research Institute of Chemical Technology
2017
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme that highly overexpressed in various cancer cells and antigen-presenting cells. It has emerged as attractive therapeutic target for immunotherapy, which prompted high interest the development of small-molecule inhibitors. To discover novel IDO1 inhibitors, we designed synthesized a series N'-hydroxyindazolecarboximidamides. Among compounds synthesized, compound 8a inhibited both tryptophan depletion kynurenine production...
1. We characterized the pharmacokinetics of tafamidis, a novel drug to treat transthyretin-related amyloidosis, in rats after intravenous and oral administration at doses 0.3-3 mg/kg. In vitro Caco-2 cell permeability liver microsomal stability, as well vivo tissue distribution plasma protein binding were also examined. 2. After injection, systemic clearance (CL), volumes steady state (Vss) half-life (T½) remained unaltered function dose, with values ranges 6.41-7.03 mL/h/kg, 270-354 mL/kg...
Objective This study aimed to develop a new oral paclitaxel formulation (DHP23002) and evaluate its absorption antitumor effects in pancreatic tumor mouse model. Methods To investigate the of DHP23002, newly developed lipid-based orally active formulation, pharmacokinetic was conducted mice (62.5 125 mg/kg). Moreover, effect DHP23002 cancer treatment, drug administered female athymic nude at 0 (vehicle), 25, 62.5, mg/kg on alternate days; efficacy agent compared with intravenous Taxol®...
The development of reliable methods to diagnose acute kidney injury is essential allow the adoption early therapeutic interventions and evaluate their effectiveness. Based on fact that molecule-1 (KIM-1) expression levels in kidneys are markedly upregulated after a damage event, here we developed noninvasive KIM-1-based molecular imaging technique detect injury. First, took advantage phage-display platform select small peptides demonstrating specific high binding affinity KIM-1. promising...