A5016347392- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- dental development and anomalies
- Dental Implant Techniques and Outcomes
- Endodontics and Root Canal Treatments
- Orthodontics and Dentofacial Orthopedics
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Dental Radiography and Imaging
- Connective tissue disorders research
- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Dental materials and restorations
- Bone and Dental Protein Studies
- Fibroblast Growth Factor Research
- Oral microbiology and periodontitis research
- Dental Trauma and Treatments
- Bone Metabolism and Diseases
- Bone health and treatments
- Tracheal and airway disorders
- Temporomandibular Joint Disorders
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Mesenchymal stem cell research
- Axon Guidance and Neuronal Signaling
International Craniofacial Institute
2007-2025
Texas A&M University
2009-2024
The University of Texas at Dallas
2024
Division of Undergraduate Education
2018
Baylor University
2010-2016
Mitchell Institute
2009-2013
Texas A&M Health Science Center
2007-2012
Baylor School
2011
Baylor College of Medicine
2000-2010
Indianapolis Zoo
2009
Cranial sutures play a critical role in calvarial morphogenesis, serving as growth centers during skull development. Both biomechanical tensile forces originating the cranial base and biochemical factors present dura mater have been postulated determinants of suture morphogenesis patency. A rat transplant model free putative influence was used to investigate both initial maintenance growth. Day 19 fetal presumptive (F19) day 1 neonatal differentiated (N1) coronal sutures, including...
Abstract A chemically defined serum-free medium, which supports the development of bones and fibrous tissues rat calvaria from nonmineralized mesenchymal precursor tissues, was employed to investigate tissue interactions between dura mater overlying tissues. Fetal calvarial rudiments stages prior bone suture morphogenesis (fetal days 19 20) neonatal with formed sutures (day 1) were cultured without associated mater. Removal for in vitro culture allowed examination absence tensional forces...
Abstract – Many solutions have been examined as possible storage media for avulsed teeth. In this report, human periodontal ligament (PDL) cells were exposed 1 h to culture medium, milk, Hanks Balanced Salt Solution (HBSS), Soft Wear, Opti Free, and Solo Care contact lens solutions, Gatorade ® , tap water, at room temperature on ice. The number of viable was counted using the trypan blue exclusion technique, immediately after exposure (0 h) 24 48 h, test proliferative capacity treatment....
Abstract Cranial sutures function as bone growth centers while themselves remaining unossified. Rat frontonasal become obliterated by neonatal day 21 (N21), coronal do not fuse over the life of animal. Coronal induced to undergo osseous obliteration in vitro after removal dura mater were found require soluble, heparin-binding factors present resist obliteration. Transforming factor β1 (TGF-β1), β2, and β3, known regulate cell proliferation differentiation, considered likely candidates. The...
Abstract Aim To test the hypothesis that MG‐63 osteosarcoma cells and primary osteoblasts react differently to ProRoot™ MTA (mineral trioxide aggregate) White by: (i) investigating attachment of MTA; (ii) comparing osteogenic behaviour both cell lines in contact with these endodontic materials. Methodology Primary were harvested from foetal rat calvaria by sequential digestion purchased. Cells exposed prepared according manufacturer's instructions. All samples controls quadruplicate. After...
Epidermal growth factor (EGF) has been found to stimulate DNA synthesis in both the trachea and bronchial tree of 5-day-old chick embryo lung rudiments organ culture. After 20 h culture presence 10 ng/ml EGF, incorporation tritiated thymidine into is stimulated two- three-fold following a 2 labelling period, as revealed by scintillation counting. Autoradiographic data indicate that this stimulation most marked epithelial tissue component tree. Supernumerary "lung" buds have induced normally...
Periodontal mesenchymal stem cells (MSCs) play a crucial role in maintaining periodontium homeostasis and tissue repair. However, little is known about how periodontal MSCs vivo respond under disease conditions, posing challenge for regeneration. In this study, Gli1 was used as MSC marker combined with Gli1-cre ERT2 mouse model lineage tracing to investigate fate an induced periodontitis model. Our findings show significant changes the number contribution of + within inflamed periodontium....
Abstract Cranial vault sutures are the major intramembranous bone growth sites during rapid expansion of neurocranium. To function as sites, need to remain patent, while allowing formation at edges fronts. Premature osseous obliteration (craniosynostosis) by fusion fronts across suture site prevents further this site, often leading severe facial dysmorphology. Although several factor receptor and transcription mutations have been implicated in craniosynostosis, underlying mechanisms sutural...
Abstract Five of the bones that characteristically comprise cranial vault articulate on lateral aspect skull at or near cephalometric landmark referred to as pterion. The pattern articulation in sutures associated with these varies among and within primate species has been used a criterion for classification taxonomic studies, well archeological forensic studies. Within species, sutural patterns found region pterion have remarkable consistency, which lead hypothesis genetic basis. Sutural...
The aim of this split-mouth experimental study was to determine (1) whether corticotomy procedures increase tooth movement and (2) the effects a second procedure after 4 weeks on rate movement. mandibular third maxillary premolars five skeletally mature male foxhounds, approximately 2 years age, were extracted. One randomly selected quadrant had buccal lingual flaps corticotomies performed around premolar; other served as control. Both quadrants initial corticotomies; one flap surgery 28...
Abstract Background The Bacillus Calmette-Guérin (BCG) vaccine induces trained immunity, an epigenetic-mediated increase in innate immune responsiveness. Therefore, this clinical trial evaluated if BCG-induced immunity could decrease COVID-19-related frequency or severity. Methods A double-blind, placebo-controlled of healthcare workers randomized participants to vaccination with BCG TICE® placebo (saline). Enrollment included 529 receive placebo. Primary analysis COVID-19 disease frequency,...
Abstract: Recombinant human bone morphogenetic protein‐2 (rhBMP‐2) induced regeneration and osseointegration was evaluated in bony defects created within the hollow chamber of endosseous dental implants 14 foxhound dogs. Bilateral extractions mandibular premolars were performed surgical implantation 104 cylinder followed after 8 weeks healing. Experimental had their filled with 20 μg rhBMP‐2 delivered a bovine collagen carrier, whereas control apical left empty. Dogs for 2, 4, 12 weeks....