Background: Cancer incidence (CI) and mortality vary significantly among countries are impacted by numerous factors including the country's income human development index (HDI). (CM) in adolescent young adult (AYA) population, age group of 15 - 39 years, has seen minimal improvement over past few decades. Our study aims to identify disparities this analyze influence HDI on these outcomes. Methods: We utilized GLOBOCAN database estimates for year 2022 185 or territories 36 cancer types trends...

463 Background: Accurately predicting postoperative outcomes, such as major and minor complications, readmissions, mortality, enables personalized preoperative planning, informed decision-making, improved perioperative management. In this study, we utilized a machine learning (ML) model to predict these outcomes in RCC patients undergoing nephroureterectomy, radical nephrectomy, partial other excision procedures on the kidney using data from National Surgical Quality Improvement Program...

347 Background: Patients diagnosed with localized high-risk prostate adenocarcinoma (LHRPC) high Gleason scores (8-10) and prostate-specific antigen (PSA) levels ≤ 4 may experience an altered clinical course. In these patients, low PSA reflect cellular dedifferentiation, indicating more aggressive tumor behavior despite appearing to have a disease burden. We aim investigate the impact of in patients LHRPC better understand prognosis optimize treatment strategies. Methods: included based on...

654 Background: Primary urethral cancer (PUC) is a rare and highly aggressive malignancy with spectrum of various histologies without an established treatment approach. Due to the lack prospective studies in patients PUC, clinical outcomes different modalities are unknown. We aimed investigate based on approaches histology. Methods: Our retrospective study included from 10 international centers United States, Europe, Asia. Eligibility criteria diagnosed invasive PUC TNM stage (T2-T4, N0-N2)....

747 Background: Understanding trends in end-of-life care for bladder cancer patients, particularly their preferred place of death (PPOD), is essential improving palliative planning. Despite being a leading cause mortality the U.S., there limited insight into how preferences settings have evolved over time, or they vary across demographic groups. Identifying these can help enhance quality and address disparities access to hospice home-based care. This study aims provide comprehensive analysis...

The study aimed to evaluate the impact of COVID-19 pandemic on levels anxiety and depressive symptoms in children adolescents.Cross-sectional surveys were carried out mental health children; one survey was conducted before into pandemic, 15 months after school closures implementation lockdown social distancing. Demographic data pandemic-related collected from specific parent-report self-report questionnaires.Participants included adolescents between ages 6 16 years, attending a tertiary care...

82 Background: The treatment paradigm for metastatic prostate cancer has significantly improved in the past decade. Nevertheless, there remains an unmet need novel biomarker-driven risk stratification. Studies have shown that genetic alterations any of PTEN, RB1, and TP53 genes influence prognosis, potential androgen independence overall survival individuals diagnosed with advanced cancer. Based on these findings, we compared rates by contrasting patients mutations to those lacking them,...

1036 Background: Breast cancer outcomes vary among HER2-amplified and HER2 low-expression patients, particularly in the presence of brain metastases (BM). Trastuzumab deruxtecan (T-DXd) is FDA approved for treatment adult patients with unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-low HER2-positive (HER2+) (pts). This study aims to evaluate impact T-DXd on overall survival low breast (MBC) without Methods: A retrospective analysis was conducted by using...

Introduction Diabetes has increased in prevalence from 108 million individuals 1980 to 463 2021. As people's life expectancies have risen, it's become increasingly necessary be worried about diseases that affect the elderly. To focus and manage these effectively, illumination of current knowledge pattern anti-diabetic drug utilization elderly is important. a result, it evaluate medication use among diabetes patients geriatric age group determine if there room for improvement light knowledge....

Dear Sir, Over two years have passed since the first new coronavirus infections were discovered in China’s Wuhan province. Since then, efforts concentrated on preventing and limiting transmission throughout early phases of epidemic. Global herd immunity studies COVID-19 shown an urgent need for effective vaccinations. The articles by Juyal et al. Raina & Kumar immunization status India caught our attention.[12] While vaccination drive has indeed been one most incredible drives history,...

e13612 Background: Healthcare costs in the United States (US) are significantly impacted by genitourinary (GU) cancers. Prostate cancer treatment alone cost US more than $22 billion 2020. We sought to utilize machine learning (ML)-based classification investigate differences total of healthcare expenditure among patients with GU US. Methods: The study included eligible adult cases from 2019–2021 Medical Expenditure Panel Survey. Renal cell, prostate, urothelial, testicular, and penile...

5045 Background: Human Papilloma Virus (HPV) infection is a favorable prognostic marker in certain cancers, particularly oropharyngeal and vulvar (SCC). Patients with pSCC have risk profile clinical course like pSCC. However, the impact of HPV status on survival remains uncertain. Methods: We conducted retrospective study using National Cancer Database included patients tested for between 2004-2021. Survival outcomes were analyzed reported as median overall (mOS, 95% CI). Multivariate...

e20133 Background: Despite advances in the management of cancer, socioeconomic disparities have been reported to impact survival outcomes. However, recent state SCLC patients with brain metastases (BM) remains unknown. We explored outcomes BM patients. Methods: conducted a retrospective cohort study and included diagnosed 2018-2019 National Cancer Database. Patients were grouped as White, Black, American Indian, Aleutian or Pacific Islander (AAPI), Asian. Socioeconomic analyzed using median...

269 Background: Machine learning has shown potential in accurately predicting outcomes after urologic surgery, allowing for improved patient selection, risk stratification, and discharge dispositions. Healthcare disparities pose a major public health challenge, leading to unequal different groups. Successful measures mitigate these rely on precise recognition of the demographic groups impacted. In this study, we utilized AI ML models predict such adverse so that early intervention may lead...

311 Background: Effective risk assessment techniques and follow-up strategies are scarce for patients with prostate cancer because of the heterogeneity population. We aimed to conduct a study better stratification, applying machine learning–based classification who underwent major surgery. Methods: identified eligible prostatectomy or surgeries related excision using data from American College Surgeons National Surgical Quality Improvement Program (ACS NSQIP) years 2016–2021. Hierarchical...

Acute respiratory syndrome coronavirus disease-2019, caused by a new (severe acute 2 [SARS-CoV-2]) with high morbidity and death rate, has emerged as one of humanity’s most serious dangers in recent decades. Because the virus’s ongoing development, its single-nucleotide polymorphism variations many lineages, determining SARS-CoV-2 infectivity is very challenging. However, it critical to do in-depth research on virus understand mechanisms pathogenicity virulence create efficient treatment...

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I (MP08)1 May 2024MP08-17 OUTCOMES OF INVASIVE PRIMARY URETHRAL CANCER IN WOMEN (IPUC): AN ANALYSIS FROM THE NATIONAL DATABASE Mohammad Arfat Ganiyani, Vivek Podder, Arjun Pon Avudaiappan, Pushan Prabhakar, Atulya Aman Khosla, Shahzaib Ahmad, Ahmad Ozair, Muni Rubens, Mukesh Roy, Murugesan Manoharan, and Rohan Garje GaniyaniMohammad Ganiyani , PodderVivek Podder AvudaiappanArjun Avudaiappan PrabhakarPushan Prabhakar...

Up to 30% of metastatic breast cancer (MBC) patients (pts) develop brain metastases (BM), significantly impacting prognosis with long-term survival being rare. This increasing incidence poses a major clinical challenge, as treatment options remain limited, and has not notably improved over decades. BM is poor prognostic factor for survival. Our study utilized the comprehensive National Cancer Database (NCDB) assess outcomes identify disparities influential factors among different subtypes...

e23142 Background: Brain tumors are highly aggressive and associated with poor prognosis. Minority populations still experience inequities in the delivery of cancer care, despite concerted efforts to reduce such disparities. We studied disparities receipt care for patients primary brain tumor. Methods: National Inpatient Sample 2017-2020 was queried identify admitted Results study were reported accordance STROBE guidelines. divided cases into two groups i.e., undergoing curative (CC)...

11077 Background: Genitourinary (GU) cancers contribute substantially to the cost of healthcare in United States (US). While advancements cancer treatment have improved patient outcomes, disparities costs persist, exacerbating financial burden on vulnerable populations. We sought investigate inpatient hospitalizations among patients with GU US. Methods: Eligible adult cases from Medical Expenditure Panel Survey (2019–2021) were included this study. ICD-10 CM codes utilized identify renal...