47 Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Early detection and accurate diagnosis are essential for improving survival rates optimizing therapeutic strategies. Recently, artificial intelligence (AI) technologies, such as machine learning algorithms, convolutional neural networks (CNNs), computer-assisted diagnostic (CAD) systems, have significantly enhanced traditional tools like colonoscopy histopathology. This systematic review...

528 Background: Liver cancer continues to be a significant public health concern, particularly among high-risk groups such as individuals with hepatitis infections, alcohol use disorders, and metabolic diseases. While liver disparities have been well-documented racial ethnic minority groups, emerging research highlights inequities within the LGBTQ community, including higher rates of risk factors limited access screening care. This literature review aims assess extent community identify gaps...

40 Background: Healthcare disparities in colorectal cancer, driven by insurance status and socioeconomic factors, lead to delayed diagnoses poorer surgical outcomes. We sought examine the impact of on presentation, treatment, in-hospital mortality CRC patients undergoing colectomy using Nationwide Inpatient Sample (NIS) database. Methods: included aged 18-65 years diagnosed with colon cancer colectomy, as identified ICD-9-CM codes, who had private insurance, Medicaid, or no from January 1,...

805 Background: There is a significant gap in oncologic research, which arises from the exclusion of LGBTQ+ individuals cancer clinical trials, compromising development personalized therapies and limiting generalizability findings. Despite known health disparities this population, including higher risk factors unique psychosocial stressors, data on trial participation remains sparse. This study aims to elucidate extent underrepresentation trials examine its impact treatment efficacy, safety,...

463 Background: Accurately predicting postoperative outcomes, such as major and minor complications, readmissions, mortality, enables personalized preoperative planning, informed decision-making, improved perioperative management. In this study, we utilized a machine learning (ML) model to predict these outcomes in RCC patients undergoing nephroureterectomy, radical nephrectomy, partial other excision procedures on the kidney using data from National Surgical Quality Improvement Program...

e23054 Background: The impact of Hospital frailty risk score on outcomes in hospitalized patients with prostate cancer has not been previously studied. This research aimed to examine the association between and outcomes. Methods: retrospective study utilized hospitalization data from National Inpatient Sample (NIS) January 1, 2020, December 31, 2020. Data a primary or secondary discharge diagnosis (ICD10-CM codes C61.0, D07.5, Z85.46) were obtained. objective was evaluate correlation cancer....

Abstract Background Many FDA-approved cancer therapies, whether as a multiagent combination or single agent, have demonstrated only modest clinical benefit. To investigate the drug development landscape, this analysis focuses on newly approved drugs are added to existing standards therapy replace former monotherapy. Methods A retrospective of package inserts and corresponding trials for treatment nonhematology solid tumor malignancies from January 2011 December 2023 was conducted categorize...

We present the case of a 60-year-old male who developed an ischemic stroke due to left ventricular (LV) thrombus emboli as complication methamphetamine-induced cardiomyopathy. The patient had history methamphetamine abuse, hypertension, and with no residual deficits presented new onset slurred speech, left-sided weakness, numbness for two hours. Computed tomography (CT) head showed acute changes, tissue plasminogen activator was given in emergency department within 30 minutes arrival. Urine...

Metronidazole is a very commonly used drug for the treatment of ailments caused by bacteria and parasites. It can treat vast array conditions like rosacea, sexually transmitted diseases (STDs), liver abscess, bedsores, etc. comes with generic side-effects nausea, vomiting, dizziness, metallic taste, also rare paresthesia, syncope, cerebellar symptoms, psychosis but mania side-effect. Here, we present case metronidazole induced in 50-year-old male no past medical history who initially...

Eagle syndrome is a rare condition characterized by an abnormally elongated styloid process with or without abnormal direction and/or ossification of the ligament. Clinically, it consists throat and neck pain radiating to ear. Here, we present case 34-year-old female complaint left-sided below ear for past year. The patient had tried different analgesics after seeing doctors, but did not resolve. After conducting radiological investigations at hospital, diagnosis was made. treated surgical...

e13659 Background: Single agents replacing previous therapies are ideal, but combination with two or more active have been proposed to decrease drug resistance, promote mechanistic synergy, and/or additive cytotoxic effects in cancer treatment. However, approval of may increase exposure new and former drugs, leading costs time commitments patients. Methods: This retrospective analysis examines all FDA-approved drugs for malignant solid tumors from January 2011 December 2022. We used the data...

e24101 Background: Breast cancer (BC) is the most common type of diagnosed, and 10-15% BC patients develop a HER2-positive disease with poor prognosis. In previous meta-analysis NCCTG N9831 NSABP B-31 trials, treatment early-stage Trastuzumab chemotherapeutic drugs improved overall survival by 37%. Trastuzumab-induced cardiotoxicity (TIC) characterized cardiac dysfunction, including decreased left ventricular ejection fraction (LVEF) heart failure. Per package inserts, incidence TIC 4-6...

Abstract Objective: This study aims to explore the characteristics of receiving palliative care and patterns utilization among breast cancer patients using a large-scale representative population-based sample. Methods: A retrospective analysis was performed on hospitalization data obtained from National Inpatient Sample (NIS) covering period January 2016 December 2019. The objective investigate disparities associated with provision who had passed away, evaluate its impact healthcare as...

Abstract Background: This study aims to investigate the age-specific outcomes of breast cancer patients undergoing aromatase inhibitors therapy. Currently, no research exists on differences in for this patient population. seeks fill knowledge gap and provide valuable insights into various these patients. Methods: retrospective analyzed hospitalization data from National Inpatient Sample (NIS) between January 2016 December 2019 using STATA/BE 17.0 statistical analysis. It focused treated with...

e14536 Background: The relationship between Body Mass Index (BMI) and cancer is a complex. We aim to study the impact of BMI on response immunotherapy in patients. Methods: did retrospective observational investigate influence different groups patients receiving Immune Checkpoint Inhibitors (ICIs) at University Vermont Cancer Centre. examined medical records people who received ICIs January 2017 June 2022 collected demographic data, including age, sex, ethnicity, stage, BMI, type metastasis....

e15071 Background: Identifying targetable oncogenic drivers and resistance mechanisms by Next-generation sequencing (NGS) is critical in Non-Small Cell Lung Cancer (NSCLC). Methods: We conducted a retrospective study at the University of Vermont Center to assess utilization NGS NSCLC. examined medical records NSCLC patients who received Immune Checkpoint Inhibitors (ICIs) as first-line therapy between January 2017 June 2022. collected demographic data, including age, sex, ethnicity, cancer...

1543 Background: Cancer-related hospitalizations constitute one of the primary drivers cancer-related healthcare expenses. Understanding burden and characteristics these is essential to appropriately direct resources, improve outcomes, avoid unnecessary hospitalizations. Our study sought evaluate national trends, reasons, disposition status, length stay, associated costs for Methods: We conducted a retrospective analysis cancer using 2008-2019 National Inpatient Sample. were identified...